Results 111 to 120 of about 992,907 (313)
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Cost Liability and Residential Space Heating Expenditures of Welfare Recipients in Germany [PDF]
Within the German welfare system, heating expenditures of recipients are in general fully covered by the government. This paper empirically tests for the hypothesis that households receiving welfare payments turn to over consumption of residential space ...
Katrin Rehdanz, Sven Stöwhase
core
District heating monitoring and control systems
, 2015 This chapter describes how district heating substations can be controlled in order to improve customer comfort and system performance, and how energy measurement data can be used to monitor the functionality of substations.
F. Sandin +3 more
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
A sustainable analysis of a detached house heating system throughout its life cycle. A case study
International Journal of Strategic Property Management, 2007 Approximately 40% of final energy is consumed in buildings both in Lithuania and the European Union. In cold climate countries major part of the consumed energy is heat.
Violeta Sasnaskaitė +2 more
doaj
Preliminary assessment of a heating system coupled with a TCM storage
, 2023 reservedRenewable energy technologies have become of great interest to decarbonize the heating and cooling sector. The adoption of energy storage technologies is crucial to overcome the intermittent nature of renewable energy sources, facilitating the ...
DOSSI, DENIS
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Health Risk of Heating Fuel Choice: A Simultaneity Causality Analysis
Combustion-generated pollutants, principally those from solid-fuels including biomass and coal when cooking and heating, bring out a significant public health hazard in both developed and developing countries. Most of the existing studies addressing this
Pagoulatos, Angelos +2 more
core
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source