Results 61 to 70 of about 2,351,400 (277)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

NEW PROGRAM OF THE BURDEN CALCULATION

Литьë и металлургия, 2004
In the article there is presented the universal computer program of calculation of burden for the different types of cast iron, smelted in cupolas and electric furnaces.
L. Z. Pisarenko, A. E. Shevchenko, F. S. Lukashevich, D. V. Kuis   +3 more
doaj  

Heating and cooling system [PDF]

, 1982
A heating and cooling apparatus capable of cyclic heating and cooling of a test specimen undergoing fatigue testing is discussed. Cryogenic fluid is passed through a block clamped to the speciment to cool the block and the specimen.
Gardner, M. R., Imig, L. A.
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

International scientific and technical conference

Литьë и металлургия, 2003
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L. Z. Pisarenko, I. A. Potapnev
doaj  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

MECHANICAL REGENERATION OF SAND WASTE

Литьë и металлургия, 2005
The experimental activation of the sand regenerator of the firm SINTO is carried out at ОАО “MZOO". It is shown that sand grains are cleared from films of binding agents, that allows to use the treated sand for preparation of agglutinant and core sands.
D. I. Gnir, E. V. Govinchik
doaj  

Numerical Study on Peak Shaving Performance of Combined Heat and Power Unit Assisted by Heating Storage in Long-Distance Pipelines Scheduled by Particle Swarm Optimization Method

Energies
Thermal energy storage in long-distance heating supply pipelines can improve the peak shaving and frequency regulation capabilities of combined heat and power (CHP) units participating in the power grid.
Haoran Ju, Yongxue Wang, Yiwu Feng, Lijun Zheng   +3 more
doaj   +1 more source

Comparative performance of twenty-three types of flat plate solar energy collectors [PDF]

, 1975
Report compares efficiencies of 23 solar collectors for four different purposes: operating a Rankine-cycle engine, heating or absorption air conditioning, heating hot water, and heating a swimming ...
Simon, F. F.
core   +1 more source

Electron and Ion Heating during Magnetic Reconnection in Weakly Collisional Plasmas

, 2015
Gyrokinetic simulations of magnetic reconnection are presented to investigate plasma heating for strongly magnetized, weakly collisional plasmas. For a low plasma beta case, parallel and perpendicular phase mixing strongly enhance energy dissipation ...
Loureiro, Nuno F., Numata, Ryusuke
core   +1 more source