Results 81 to 90 of about 992,907 (313)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
EnergiesThis study examines the impact of chilled water supply parameters on the energy efficiency of an office building’s HVAC system located in a temperate European climate.
Szymon Salamondra +2 more
doaj +1 more source
On the use of surplus electricity in district heating systems
, 2014 Maintained balance between supply and demand is a fundamental prerequisite for proper operation of electric power grids. For this end, power systems rely on accessibility to various balancing technologies and solutions by which fluctuations in supply and
Ingvarsson, Paul +3 more
core
Passive solar-energy air-heating wall panels [PDF]
, 1987 The development of products which enable passive solar-energy air-heating to be integrated into the heating strategies of public, commercial and industrial buildings is described. These buildings are, in general, only occupied significantly during the
Hobday, R. A.
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
DEVELOPMENT AND MASTERING OF PRODUCTION TECHNOLOGY OF GRINDING BODIES IN DISPOSABLE SAND- CLAY MOLDS
Литьë и металлургия, 2011 The carried out experimental and scientific-research works enabled to organize mass production of grinding bodies, which being successfully tested at the enterprises of building industry of the Republic of Belarus now.
I. A. Busel +3 more
doaj
Thermoeconomics as a tool for the design and analysis of energy savings initiatives in buildings connected to district heating networks [PDF]
, 2012 District Heating (DH) is a rational way to supply heat to buildings in urban areas. This is expected to play an important role in future energy scenarios, mainly because of the possibility to recover waste heat and to integrate renewable energy sources ...
Kona Albana +2 more
core
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
DETERMINANTS OF RESIDENTIAL SPACE HEATING EXPENDITURES IN GERMANY [PDF]
We first examine the determinants of household expenditures on space heating and hot water supply in Germany. A number of socio-economic characteristics of households are included along with building characteristics.
Katrin Rehdanz
core
The effects on health of a publicly funded domestic heating programme: a prospective controlled study [PDF]
, 2009 <b>Objective</b>: To assess the effect of a publicly funded domestic heating programme on self-reported health. <b>Design, setting and participants</b>: A prospective controlled study of 1281 households in Scotland receiving ...
Mitchell, R. +7 more
core +1 more source