Results 61 to 70 of about 87,039 (260)

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Degree-Day Climatology over Central and Southeast Europe for the Period 1961-2018 – Evaluation in High Resolution

Cybernetics and Information Technologies, 2020
The ongoing climate change over Central and Southeast Europe has a great potential to affect significantly the public energy demands and in particular the energy consumption in the residential heating and cooling sector.
Chervenkov Hristo, Ivanov Vladimir, Gadzhev Georgi, Ganev Kostadin, Melas Dimitrios   +4 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Evaluation and Projection of Degree-Days and Degree-Days Categories in Southeast Europe Using EURO-CORDEX

Atmosphere
The temperature-based indicators heating and cooling degree days, are frequently utilized to quantitatively link indoor energy demand and outdoor thermal conditions, especially in the context of climate change.
Hristo Chervenkov, Kiril Slavov
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Heating and Cooling Requirements in Relation to Broiler Breeding, Case Study: Khorasan Razavi Province, Iran [PDF]

تحقیقات کاربردی علوم جغرافیایی
The performance of broiler chickens is directly influenced by temperature changes and the occurrence of heat stress, whether it is cold or hot. The present study aims to assess the cooling and heating degree days in different stages of broiler chicken ...
Mohammad Baaghideh, Motahhareh Zargari
doaj  

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Combining heating degree days method and machine learning techniques: implementation of a new model for mapping buildings heating demand at urban scale

Energy Conversion and Management: X
Building’s energy renovation holds significant potential for reducing energy consumption in the building sector. Consequently, there is a growing momentum to extend the concept of nearly zero-energy buildings to entire districts, fostering the ...
Milagros Álvarez-Sanz, Cristina Villanueva-Díaz, Álvaro Campos-Celador, Jon Terés-Zubiaga, Pello Larrinaga   +4 more
doaj   +1 more source