Results 41 to 50 of about 90,093 (253)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Forecasting Day-Ahead Electricity Demand in Australia Using a CNN-LSTM Model with an Attention Mechanism

Applied Sciences
Accurate energy demand forecasting is vital for optimizing resource allocation and energy efficiency. Despite advancements in various prediction models, existing approaches often struggle to capture the complex, nonlinear relationships between ...
Laial Alsmadi, Gang Lei, Li Li
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

An advanced data analysis method using heating degree-days for estimating the efficiency of buildings in smart cities: A case study of Astana

Results in Engineering
Heating of buildings account for over 40% of global energy consumption and approximately 30% of carbon dioxide emissions. In Kazakhstan, achieving optimal energy efficiency and thermal comfort in residential buildings is particularly challenging due to ...
Ruslan Omirgaliyev, Ayagoz Khamzina, Didar Yedilkhan, Prof, Daniel Friedrich, Nurkhat Zhakiyev   +4 more
doaj   +1 more source

Building energy model validation and estimation using heating and cooling degree days (HDD–CDD) based on accurate base temperature

Energy Science & Engineering, 2022
A great deal of energy used in buildings is directed toward heating, ventilation, and air‐conditioning (HVAC). The key procedure in reducing heating and cooling loads is the creation of a baseline model that represents a theoretical version of the ...
Mahmood Mehregan, Alireza Naminezhad, Sajjad Vakili, Mostafa Delpisheh   +3 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Determination of heating and cooling degree-day values and heating and cooling-days in broiler husbandry: central Anatolian case

Engineering for Rural Development, 2018
The general aim of barns is to create suitable environments for animals against adverse weather conditions. Barns should be designed in such a way as to minimize the effect of weather changes and keep indoor conditions at the values of animals' desire.
Atilgan, Atilgan, Yucel, Ali, Saltuk, Burak   +2 more
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Spatiotemporal changes in the length and heating degree days of the heating period in Northeast China [PDF]

Meteorological Applications, 2017
ABSTRACTAs the coolest region in China, Northeast China has long and severe winters and is a main region for the use of central heating. Accurately predicting the heating energy consumption in Northeast China is very important for energy management and planning.
Xiang‐Jin Shen, Bin‐Hui Liu, Dao‐Wei Zhou   +2 more
openaire   +1 more source