Results 31 to 40 of about 423 (206)

Population‐weighted heating degree‐days for Canada [PDF]

open access: yesAtmosphere-Ocean, 1981
Abstract The use of population‐weighted heating degree‐days provides a more realistic estimate of the potential fuel demand for residential heating on a regional, provincial or national basis than the use of unweighted, site‐specific heating degree‐day values.
openaire   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Analysis of cooling and heating degree days in the United States from 2015 to 2024 [PDF]

open access: yesE3S Web of Conferences
A sizable portion of the electricity consumed in buildings is due to the thermal load associated with the location of these buildings. Specific environmental characteristics can be translated into factors that allow researchers to understand the ...
Barbosa Priscila M.   +3 more
doaj   +1 more source

Climate Change Effects on Heating and Cooling Demands of Buildings in Canada

open access: yesCivilEng, 2022
Climate change is causing more frequent extreme weather events. The consequences of increasing global temperature on the operating cost of existing buildings, and the associated health, safety, and economic risks were investigated.
Samir E. Chidiac, Lan Yao, Paris Liu
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Climate Change and Vulnerabilities of the European Energy Balance

open access: yesJournal of Sustainable Development of Energy, Water and Environment Systems, 2015
Energy consumption induces climate change but at the same time modifications in climate impact energy sector both in term of supply capacity and shifts in energy demands.
Giuliano Buceti
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Heating and cooling degree-days vs climate change in years 1979-2021. Evidence from the European Union and Norway

open access: yesEconomics and Environment
Energy consumption depends strongly on weather conditions. Thus, to formulate energy-related policy goals, it is crucial to monitor changes related to the heating degree days (HDD) and cooling degree days (CDD) – widely applied indicators of climate ...
Sylwia Pangsy-Kania   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

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