Results 31 to 40 of about 90,093 (253)

Climatic projections of heating season in Ukraine up to the middle of the 21st century

Геофизический журнал, 2019
The paper presents projections for the balanced scenario A1B of specialized climatic indicators of the heating period for the territory of Ukraine for decades until the middle of the 21st century.
S. V. Krakovska, L. V. Palamarchuk, T. M. Shpytal   +2 more
doaj   +1 more source

Climate Change Effects on Heating and Cooling Demands of Buildings in Canada

CivilEng, 2022
Climate change is causing more frequent extreme weather events. The consequences of increasing global temperature on the operating cost of existing buildings, and the associated health, safety, and economic risks were investigated.
Samir E. Chidiac, Lan Yao, Paris Liu
doaj   +1 more source

Population‐weighted heating degree‐days for Canada [PDF]

Atmosphere-Ocean, 1981
Abstract The use of population‐weighted heating degree‐days provides a more realistic estimate of the potential fuel demand for residential heating on a regional, provincial or national basis than the use of unweighted, site‐specific heating degree‐day values.
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Analysis of cooling and heating degree days in the United States from 2015 to 2024 [PDF]

E3S Web of Conferences
A sizable portion of the electricity consumed in buildings is due to the thermal load associated with the location of these buildings. Specific environmental characteristics can be translated into factors that allow researchers to understand the ...
Barbosa Priscila M., Goossen Keith W., Hyman Joshua, Maravilla Garcia Brandon   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Climate Change and Vulnerabilities of the European Energy Balance

Journal of Sustainable Development of Energy, Water and Environment Systems, 2015
Energy consumption induces climate change but at the same time modifications in climate impact energy sector both in term of supply capacity and shifts in energy demands.
Giuliano Buceti
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Heating and cooling degree-days vs climate change in years 1979-2021. Evidence from the European Union and Norway

Economics and Environment
Energy consumption depends strongly on weather conditions. Thus, to formulate energy-related policy goals, it is crucial to monitor changes related to the heating degree days (HDD) and cooling degree days (CDD) – widely applied indicators of climate ...
Sylwia Pangsy-Kania, Justyna Biegańska, Floros Flouros, Aneta Sokół   +3 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source