Results 101 to 110 of about 895,159 (303)

A Tool to Assess Heating Efficiency of Direct-fired Heater with the Impact of Humidity Control [PDF]

, 2014
Heating is one of the top two expenses of greenhouse operations in northern climates. Direct-fired heater (DFH) that has been promoted having high heating efficiency, 99.9%, compared to 80-94% of conventional indirect-fired heaters (IFH), could be an ...
Lee, Wee Fong
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Simulation and optimization of heat transfer in underground in-situ shale upgrading

Youqi dizhi yu caishoulu
In-situ heating and upgrading technology is a key method to improve the recovery efficiency of shale oil and gas with medium-low maturity. It aims to simulate and optimize the heat transfer effects of underground shales during the in-situ heating and ...
LI Yuan, ZHONG Anhai, QIAN Qin, YU Denglang, ZHANG Yuzhe, ZHONG Yanlei, WANG Dan   +6 more
doaj   +1 more source

use natural gas consumption in 201Scenarios to decarbonize residential water heating in California [PDF]

, 2017
This paper presents the first detailed long-term stock turnover model to investigate scenarios to decarbonize the residential water heating sector in California, which is currently dominated by natural gas.
Kammen, Daniel M, Raghavan, Shuba V, Wei, Max   +2 more
core  

General-relativistic model of hot accretion flows with global Compton cooling

, 2011
We present a model of optically thin, two-temperature, accretion flows using an exact Monte Carlo treatment of global Comptonization, with seed photons from synchrotron and bremsstrahlung emission, as well as with a fully general relativistic description
Abdo, Abramowicz, Andrzej A. Zdziarski, Andrzej Niedźwiecki, Balmaverde, Beckmann, Bisnovatyi-Kogan, Chiaberge, Constantin, Corbel, Dermer, Done, Esin, Esin, Esin, Esin, Esin, Esin, Evans, Fu-Guo Xie, Gammie, Grandi, Grove, Gu, Heinz, Ho, Häring-Neumayer, Ichimaru, Krolik, Kurpiewski, Kurpiewski, Li, Machida, Mahadevan, Manmoto, Manmoto, Markowitz, McClintock, Meisenheimer, Merloni, Miyakawa, Nakamura, Narayan, Narayan, Narayan, Narayan, Niedźwiecki, Niedźwiecki, Oda, Paczyński, Page, Park, Piran, Popham, Quataert, Quataert, Rajesh, Rees, Rothschild, Russell, Sharma, Sobolewska, Steinle, Veledina, Wardziński, Whysong, Wu, Wu, Xie, Yamaoka, Younes, Yuan, Yuan, Yuan, Yuan, Yuan, Yuan, Yuan, Yuan, Zdziarski, Zdziarski, Zdziarski   +81 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Structural solutions impact on thermal energy efficiency of heating surface at an open space

Journal of Civil Engineering and Management, 2013
This paper presents studies on thermal energy efficiency of heating surface at an open space according to structural solutions and climatic conditions. Numerical simulation research was conducted to assess three different types of heating surfaces at an ...
Dobrosława Kaczorek, Halina Koczyk
doaj   +1 more source

Air Conditioning Hybrid Electric Vehicles while Stopped in Traffic [PDF]

, 2004
HEVs idle their engine during the stops to meet the cooling and heating needs. But, idling decreases fuel economy and increases engine wear and emissions.
Bullard, C.W., Malik, T.
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source