Results 101 to 110 of about 892,923 (305)

Influence of multi-stage infrared heating on the efficiency and uniformity of asphalt pavement hot in-place recycling

AIP Advances
To enhance heating uniformity and efficiency in the hot in-place recycling process of asphalt pavements, a multi-stage infrared intermittent heating method is developed through the creation of a physical and mathematical model for collaborative heating ...
Ruixuan Zhang, Miao Yu
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Weatherization: A Step Towards Green Cities [PDF]

, 2007
Home heating is a basic necessity that comes at a very high cost, particularly for residents in the city of Buffalo. Weatherization is an efficient and affordable method for reducing energy costs by increasing home energy efficiency.
Town, Rebecca
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Simulation and optimization of heat transfer in underground in-situ shale upgrading

Youqi dizhi yu caishoulu
In-situ heating and upgrading technology is a key method to improve the recovery efficiency of shale oil and gas with medium-low maturity. It aims to simulate and optimize the heat transfer effects of underground shales during the in-situ heating and ...
LI Yuan, ZHONG Anhai, QIAN Qin, YU Denglang, ZHANG Yuzhe, ZHONG Yanlei, WANG Dan   +6 more
doaj   +1 more source

General-relativistic model of hot accretion flows with global Compton cooling

, 2011
We present a model of optically thin, two-temperature, accretion flows using an exact Monte Carlo treatment of global Comptonization, with seed photons from synchrotron and bremsstrahlung emission, as well as with a fully general relativistic description
Abdo, Abramowicz, Andrzej A. Zdziarski, Andrzej Niedźwiecki, Balmaverde, Beckmann, Bisnovatyi-Kogan, Chiaberge, Constantin, Corbel, Dermer, Done, Esin, Esin, Esin, Esin, Esin, Esin, Evans, Fu-Guo Xie, Gammie, Grandi, Grove, Gu, Heinz, Ho, Häring-Neumayer, Ichimaru, Krolik, Kurpiewski, Kurpiewski, Li, Machida, Mahadevan, Manmoto, Manmoto, Markowitz, McClintock, Meisenheimer, Merloni, Miyakawa, Nakamura, Narayan, Narayan, Narayan, Narayan, Niedźwiecki, Niedźwiecki, Oda, Paczyński, Page, Park, Piran, Popham, Quataert, Quataert, Rajesh, Rees, Rothschild, Russell, Sharma, Sobolewska, Steinle, Veledina, Wardziński, Whysong, Wu, Wu, Xie, Yamaoka, Younes, Yuan, Yuan, Yuan, Yuan, Yuan, Yuan, Yuan, Yuan, Zdziarski, Zdziarski, Zdziarski   +81 more
core   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Structural solutions impact on thermal energy efficiency of heating surface at an open space

Journal of Civil Engineering and Management, 2013
This paper presents studies on thermal energy efficiency of heating surface at an open space according to structural solutions and climatic conditions. Numerical simulation research was conducted to assess three different types of heating surfaces at an ...
Dobrosława Kaczorek, Halina Koczyk
doaj   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source