Results 11 to 20 of about 852,733 (217)
Job-shop scheduling with an adaptive neural network and local search hybrid approach [PDF]
, 2006 This article is posted here with permission from IEEE - Copyright @ 2006 IEEEJob-shop scheduling is one of the most difficult production scheduling problems in industry.
Yang, S +3 more
core +1 more source
A linear programming-based method for job shop scheduling [PDF]
, 2012 We present a decomposition heuristic for a large class of job shop scheduling problems. This heuristic utilizes information from the linear programming formulation of the associated optimal timing problem to solve subproblems, can be used for any ...
Bülbül, Kerem, Kaminsky, Philip
core +1 more source
A Broader View of the Job-Shop Scheduling Problem
, 2008 We define a job-shop scheduling problem with three dynamic decisions: assigning due-dates to exogenously arriving jobs, releasing jobs from a backlog to the shop floor, and sequencing jobs at each of two workstations in the shop.
Lawrence M. Wein, Philippe B. Chevalier
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
On the take-off of heavily loaded airplanes [PDF]
, 1928 This report examines the take-off conditions of airplanes equipped with tractive propellers, and particularly the more difficult take-off of airplanes heavily loaded per unit of wing area (wing loading) or per unit of engine power (power loading)
Breguet, Louis
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Heavily Loaded Vehicle Tires: Analysis and Characterization [PDF]
, 2008 Vibration characterization and experimental modal analysis were carried out with a heavily loaded vehicle tire. These tires are typically subjected to loads that are over two times those experienced by a passenger car tire.
Garcia, Nicholas
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source