Results 21 to 30 of about 20,037 (228)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Prospector carrying supplies, White Pass, British Columbia, between 1893 and 1903 [PDF]
, 1898 PH Coll 1354.5bFlorence Hartshorn arrived in Skagway July 1, 1898, and went to join her husband, Albert Hartshorn, at Log Cabin in the Yukon, where he had a blacksmith shop.
core
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Pack train at White Pass, British Columbia, between 1893 and 1903 [PDF]
, 1898 PH Coll 1354.5aFlorence Hartshorn arrived in Skagway July 1, 1898, and went to join her husband, Albert Hartshorn, at Log Cabin in the Yukon, where he had a blacksmith shop.
core
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Lake at White Pass, British Columbia, between 1893 and 1903 [PDF]
, 1898 PH Coll 1354.3bFlorence Hartshorn arrived in Skagway July 1, 1898, and went to join her husband, Albert Hartshorn, at Log Cabin in the Yukon, where he had a blacksmith shop.
core
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Waterfall at White Pass, British Columbia, between 1893 and 1903 [PDF]
, 1898 PH Coll 1354.4bFlorence Hartshorn arrived in Skagway July 1, 1898, and went to join her husband, Albert Hartshorn, at Log Cabin in the Yukon, where he had a blacksmith shop.
core
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source