Results 291 to 300 of about 398,844 (320)
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Annals of the New York Academy of Sciences, 1971
The recent elucidation of the structure of immunoglobulins, and the more precise immunologic and chemical characterization of the proteins produced by patients with proliferative disorders of plasma cells and lymphocytes have led to a clearer understanding of the biosynthetic alterations accompanying them.
B. Frangione +2 more
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The recent elucidation of the structure of immunoglobulins, and the more precise immunologic and chemical characterization of the proteins produced by patients with proliferative disorders of plasma cells and lymphocytes have led to a clearer understanding of the biosynthetic alterations accompanying them.
B. Frangione +2 more
openaire +3 more sources
Current Treatment Options in Oncology, 2002
The heavy chain diseases (HCDs) are rare B-cell malignancies that are distinguished by the production of a monoclonal immunoglobulin heavy chain (HC) without an associated light chain by the malignant B-cells. There are three types of HCD defined by the class of immunoglobulin (Ig) HC produced: IgA (alpha-HCD), IgG (gamma-HCD), and IgM (mu-HCD).
Thomas E. Witzig +1 more
openaire +3 more sources
The heavy chain diseases (HCDs) are rare B-cell malignancies that are distinguished by the production of a monoclonal immunoglobulin heavy chain (HC) without an associated light chain by the malignant B-cells. There are three types of HCD defined by the class of immunoglobulin (Ig) HC produced: IgA (alpha-HCD), IgG (gamma-HCD), and IgM (mu-HCD).
Thomas E. Witzig +1 more
openaire +3 more sources
Structure of Abnormal Heavy Chains in Human Heavy-chain-deposition Disease
European Journal of Biochemistry, 1995The sequences of two immunoglobulin gamma 1 heavy chains involved in the formation of non-amyloid tissue deposits were determined in two patients (RIC and THR) affected with plasma cell monoclonal proliferation and heavy-chain-deposition disease. The proliferating plasma cells of patients RIC and THR synthesized truncated gamma 1 chains of 45 kDa and ...
Jean-Louis Preud'homme +3 more
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Light Chains With Heavy Effects
American Journal of Kidney Diseases, 2020https://www.ncbi.nlm.nih.gov/pubmed ...
Obici, L., Merlini, G.
openaire +4 more sources
Clinics in Laboratory Medicine, 1986
A review of alpha-heavy chain disease (AHCD) emphasizing its histopathology and associated lesions is presented. Unusual clinicopathologic presentations and modern concepts regarding histogenesis of AHCD in the light of recent immunohistochemical findings are discussed.
Parviz Haghighi, Paul L. Wolf
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A review of alpha-heavy chain disease (AHCD) emphasizing its histopathology and associated lesions is presented. Unusual clinicopathologic presentations and modern concepts regarding histogenesis of AHCD in the light of recent immunohistochemical findings are discussed.
Parviz Haghighi, Paul L. Wolf
openaire +3 more sources
Clinical Lymphoma Myeloma and Leukemia, 2020
Heavy chain disorders are rare B-cell disorders and include heavy chain disease, heavy chain deposition disease, and heavy chain amyloidosis. These disorders share the pathognomonic finding of a truncated immunoglobulin heavy chain without an associated light chain in the serum or urine in the case of heavy chain disease or in the tissues in the case ...
Sara Singer +7 more
openaire +3 more sources
Heavy chain disorders are rare B-cell disorders and include heavy chain disease, heavy chain deposition disease, and heavy chain amyloidosis. These disorders share the pathognomonic finding of a truncated immunoglobulin heavy chain without an associated light chain in the serum or urine in the case of heavy chain disease or in the tissues in the case ...
Sara Singer +7 more
openaire +3 more sources
1986
Heavy chain diseases (HCD) are immunoproliferative disorders characterized by the production of monoclonal immunoglobulin molecules composed of deleted heavy chains devoid of light chains. The diagnosis is established by immunoelectrophoresis (possibly combined to immunoselection) or immunofixation.
openaire +6 more sources
Heavy chain diseases (HCD) are immunoproliferative disorders characterized by the production of monoclonal immunoglobulin molecules composed of deleted heavy chains devoid of light chains. The diagnosis is established by immunoelectrophoresis (possibly combined to immunoselection) or immunofixation.
openaire +6 more sources
Analysis of patients with γ-heavy chain disease by the heavy/light chain and free light chain assays
Clinical Chemistry and Laboratory Medicine, 2014The objective of this study was to evaluate the performance of the heavy/light chain and free light chain immunoassays in patients with heavy chain disease, and to assess the ability of the heavy/light chain assay to measure and confirm the abnormal, truncated heavy chain.Frozen serum samples from 15 γ-heavy chain disease patients were tested for IgGκ,
Robert A. Kyle +3 more
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The Physics Teacher, 2011
While perusing various websites in search of a more challenging lab for my students, I came across a number of ideas where replacing the string in an Atwood's machine1 with a simple ball chain like the kind found in lamp pulls created an interesting system to investigate.
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While perusing various websites in search of a more challenging lab for my students, I came across a number of ideas where replacing the string in an Atwood's machine1 with a simple ball chain like the kind found in lamp pulls created an interesting system to investigate.
openaire +2 more sources
La Ricerca in Clinica e in Laboratorio, 1976
Human heavy chain diseases offer an opportunity to examine the molecular events taking place in cells which produce naturally occurring structural variants of a well-studied complex protein. Extensive structural analyses have been carried out on many of these proteins and have revealed the existence of certain characteristic features.
Joel N. Buxbaum, Joel N. Buxbaum
openaire +2 more sources
Human heavy chain diseases offer an opportunity to examine the molecular events taking place in cells which produce naturally occurring structural variants of a well-studied complex protein. Extensive structural analyses have been carried out on many of these proteins and have revealed the existence of certain characteristic features.
Joel N. Buxbaum, Joel N. Buxbaum
openaire +2 more sources