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Clinics in Laboratory Medicine, 1986
A review of alpha-heavy chain disease (AHCD) emphasizing its histopathology and associated lesions is presented. Unusual clinicopathologic presentations and modern concepts regarding histogenesis of AHCD in the light of recent immunohistochemical findings are discussed.
P, Haghighi, P L, Wolf
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A review of alpha-heavy chain disease (AHCD) emphasizing its histopathology and associated lesions is presented. Unusual clinicopathologic presentations and modern concepts regarding histogenesis of AHCD in the light of recent immunohistochemical findings are discussed.
P, Haghighi, P L, Wolf
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1986
Heavy chain diseases (HCD) are immunoproliferative disorders characterized by the production of monoclonal immunoglobulin molecules composed of deleted heavy chains devoid of light chains. The diagnosis is established by immunoelectrophoresis (possibly combined to immunoselection) or immunofixation.
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Heavy chain diseases (HCD) are immunoproliferative disorders characterized by the production of monoclonal immunoglobulin molecules composed of deleted heavy chains devoid of light chains. The diagnosis is established by immunoelectrophoresis (possibly combined to immunoselection) or immunofixation.
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Archives of Internal Medicine, 1972
To the Editor. —We read with interest the paper in the September issue1 on αheavy chain disease in which the pathological immunoglobulin disappeared with chemotherapy. The authors state that up to the time of acceptance of their paper all cases of so-called Mediterranean lymphoma and α-chain disease have occurred either in Arabs or oriental Jews in ...
B H, Novis, S, Bank
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To the Editor. —We read with interest the paper in the September issue1 on αheavy chain disease in which the pathological immunoglobulin disappeared with chemotherapy. The authors state that up to the time of acceptance of their paper all cases of so-called Mediterranean lymphoma and α-chain disease have occurred either in Arabs or oriental Jews in ...
B H, Novis, S, Bank
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European Journal of Immunology, 1978
AbstractUsing cultured mouse myeloma cells, it has been possible to derive cells which are now synthesizing products similar to human heavy chain disease proteins. An initial mutant was isolated which synthesized a heavy chain with an internal deletion and a normal light chain.
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AbstractUsing cultured mouse myeloma cells, it has been possible to derive cells which are now synthesizing products similar to human heavy chain disease proteins. An initial mutant was isolated which synthesized a heavy chain with an internal deletion and a normal light chain.
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Production of Chimeric Heavy-Chain Antibodies
2008Antibody has become a major category of therapeutics. However, IgG, the primary molecular format of existing antibody drugs, has some major shortcomings such as undesirable pharmacokinetics, high dose requirement, and high production cost, partially due to its large molecular size.
Zhang, Jianbing +2 more
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1991
The heavy chain disease is a “true” form of paraproteinemia. The existance of the μ, γ, and α heavy chain disease is well documented. The δ-type heavy chain seems to be a special form of a IgD-myeloma (20, 102). The immunochemical differences within the — μ, γ, α — are accompanied with specific clinical symptoms.
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The heavy chain disease is a “true” form of paraproteinemia. The existance of the μ, γ, and α heavy chain disease is well documented. The δ-type heavy chain seems to be a special form of a IgD-myeloma (20, 102). The immunochemical differences within the — μ, γ, α — are accompanied with specific clinical symptoms.
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Nihon rinsho. Japanese journal of clinical medicine, 1995
Heavy chain diseases (HCDs) are monoclonal, lymphoproliferative disorders characterized by the production of incomplete heavy chains, devoid of light chains. Since the first report of gamma-HCD in 1964, alpha-HCD and mu-HCD have also been described. The clinical features of gamma-HCD may vary considerably.
S, Nomura, T, Kanoh
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Heavy chain diseases (HCDs) are monoclonal, lymphoproliferative disorders characterized by the production of incomplete heavy chains, devoid of light chains. Since the first report of gamma-HCD in 1964, alpha-HCD and mu-HCD have also been described. The clinical features of gamma-HCD may vary considerably.
S, Nomura, T, Kanoh
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Gamma Heavy Chain Disease. Where the Heavy Chains Arise
American Journal of Clinical Pathology, 1983William T. Pastuszak +3 more
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1994
Abstract The rat clathrin heavy chain is encoded by one gene, and there is no evidence for the existence of pseudogenes. Since the same single mRNA species is present in various tissues, it is believed that within the resolution of the RNA blots, clathrin heavy chain is not alternatively spliced.
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Abstract The rat clathrin heavy chain is encoded by one gene, and there is no evidence for the existence of pseudogenes. Since the same single mRNA species is present in various tissues, it is believed that within the resolution of the RNA blots, clathrin heavy chain is not alternatively spliced.
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