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Comparative analysis of cerebrospinal fluid neurofilament medium, light and heavy chain in neurodegenerative diseases using an in-house assay for the detection of neurofilament medium chain. [PDF]
EBioMedicineFazeli B +15 more
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Effect of NF-κB on Myosin Heavy Chain Content and Muscle Atrophy After Laryngeal Muscle Denervation. [PDF]
World J Otorhinolaryngol Head Neck SurgYang JJ, Hu R, Wang HZ, Li XY, Xu W.
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Clinical Lymphoma, Myeloma and Leukemia, 2020
Heavy chain disorders are rare B-cell disorders and include heavy chain disease, heavy chain deposition disease, and heavy chain amyloidosis. These disorders share the pathognomonic finding of a truncated immunoglobulin heavy chain without an associated light chain in the serum or urine in the case of heavy chain disease or in the tissues in the case ...
Sara J Singer +2 more
exaly +3 more sources
Heavy chain disorders are rare B-cell disorders and include heavy chain disease, heavy chain deposition disease, and heavy chain amyloidosis. These disorders share the pathognomonic finding of a truncated immunoglobulin heavy chain without an associated light chain in the serum or urine in the case of heavy chain disease or in the tissues in the case ...
Sara J Singer +2 more
exaly +3 more sources
New England Journal of Medicine, 1968
Abstract In a seventh patient with heavy-chain disease the clinical findings were those of a malignant lymphoma without skeletal involvement. The patient's serum and urine contained an M component with electrophoretic, antigenic and ultracentrifugal properties resembling those of the Fc fragment of γG globulin.
L L, Ellman, K J, Bloch
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Abstract In a seventh patient with heavy-chain disease the clinical findings were those of a malignant lymphoma without skeletal involvement. The patient's serum and urine contained an M component with electrophoretic, antigenic and ultracentrifugal properties resembling those of the Fc fragment of γG globulin.
L L, Ellman, K J, Bloch
+7 more sources
Best Practice & Research Clinical Haematology, 2005
Heavy chain diseases (HCDs) are rare B-cell lymphoplasma-cell proliferative disorders characterized by production of truncated monoclonal immunoglobulin heavy chains without associated light chains. HCDs involving the three main immunoglobulin classes have been described; alpha-HCD is the most common and has the most uniform presentation, gamma- and mu-
Dietlind L, Wahner-Roedler +1 more
openaire +2 more sources
Heavy chain diseases (HCDs) are rare B-cell lymphoplasma-cell proliferative disorders characterized by production of truncated monoclonal immunoglobulin heavy chains without associated light chains. HCDs involving the three main immunoglobulin classes have been described; alpha-HCD is the most common and has the most uniform presentation, gamma- and mu-
Dietlind L, Wahner-Roedler +1 more
openaire +2 more sources
Hematology/Oncology Clinics of North America, 1999
This review underscores the diversity of the structural and genetic abnormalities of HCD proteins and of the clinicopathologic features of the underlying lymphoproliferative disorders. Cells producing HCD may, however, all derive from a common normal precursor, which could be a rare B cell in the process of immunoglobulin gene somatic mutation within ...
J P, Fermand, J C, Brouet
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This review underscores the diversity of the structural and genetic abnormalities of HCD proteins and of the clinicopathologic features of the underlying lymphoproliferative disorders. Cells producing HCD may, however, all derive from a common normal precursor, which could be a rare B cell in the process of immunoglobulin gene somatic mutation within ...
J P, Fermand, J C, Brouet
openaire +2 more sources
Annals of the New York Academy of Sciences, 1971
The recent elucidation of the structure of immunoglobulins, and the more precise immunologic and chemical characterization of the proteins produced by patients with proliferative disorders of plasma cells and lymphocytes have led to a clearer understanding of the biosynthetic alterations accompanying them.
E C, Franklin, B, Frangione, S, Cooper
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The recent elucidation of the structure of immunoglobulins, and the more precise immunologic and chemical characterization of the proteins produced by patients with proliferative disorders of plasma cells and lymphocytes have led to a clearer understanding of the biosynthetic alterations accompanying them.
E C, Franklin, B, Frangione, S, Cooper
openaire +2 more sources
Current Treatment Options in Oncology, 2002
The heavy chain diseases (HCDs) are rare B-cell malignancies that are distinguished by the production of a monoclonal immunoglobulin heavy chain (HC) without an associated light chain by the malignant B-cells. There are three types of HCD defined by the class of immunoglobulin (Ig) HC produced: IgA (alpha-HCD), IgG (gamma-HCD), and IgM (mu-HCD).
Thomas E, Witzig +1 more
openaire +2 more sources
The heavy chain diseases (HCDs) are rare B-cell malignancies that are distinguished by the production of a monoclonal immunoglobulin heavy chain (HC) without an associated light chain by the malignant B-cells. There are three types of HCD defined by the class of immunoglobulin (Ig) HC produced: IgA (alpha-HCD), IgG (gamma-HCD), and IgM (mu-HCD).
Thomas E, Witzig +1 more
openaire +2 more sources
Light Chains With Heavy Effects
American Journal of Kidney Diseases, 2020https://www.ncbi.nlm.nih.gov/pubmed ...
Obici, L., Merlini, G.
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Structure of Abnormal Heavy Chains in Human Heavy-chain-deposition Disease
European Journal of Biochemistry, 1995The sequences of two immunoglobulin gamma 1 heavy chains involved in the formation of non-amyloid tissue deposits were determined in two patients (RIC and THR) affected with plasma cell monoclonal proliferation and heavy-chain-deposition disease. The proliferating plasma cells of patients RIC and THR synthesized truncated gamma 1 chains of 45 kDa and ...
A A, Khamlichi +3 more
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