Results 301 to 310 of about 398,844 (320)
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European Journal of Immunology, 1978
AbstractUsing cultured mouse myeloma cells, it has been possible to derive cells which are now synthesizing products similar to human heavy chain disease proteins. An initial mutant was isolated which synthesized a heavy chain with an internal deletion and a normal light chain.
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AbstractUsing cultured mouse myeloma cells, it has been possible to derive cells which are now synthesizing products similar to human heavy chain disease proteins. An initial mutant was isolated which synthesized a heavy chain with an internal deletion and a normal light chain.
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Production of Chimeric Heavy-Chain Antibodies
2008Antibody has become a major category of therapeutics. However, IgG, the primary molecular format of existing antibody drugs, has some major shortcomings such as undesirable pharmacokinetics, high dose requirement, and high production cost, partially due to its large molecular size.
Zhang, Jianbing +2 more
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Functional heavy-chain antibodies in camelidae
2001Publisher Summary This chapter focuses on the steps that are involved in the ontogeny of a heavy-chain antibody (HCAb), starting from distinct genes. HCAb is defined as an immunoglobulin devoid of light (L) chains. The presence of HCAbs in human serum is reported as a pathological disorder. It seems that, besides the absence of L chain, the heavy (H)
Nguyen, Viet Khong +2 more
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Heavy chain disease: our experience
Clinical Chemistry and Laboratory Medicine (CCLM), 2017Heavy chain disease (HCD) is a rare lymphoproliferative disorder of plasma cells, described for the first time in 1964 by Franklin [1], characterized by production of incomplete monoclonal immunoglobulin heavy chains without associated light chains [2].
Gulli, Francesca +5 more
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1991
The heavy chain disease is a “true” form of paraproteinemia. The existance of the μ, γ, and α heavy chain disease is well documented. The δ-type heavy chain seems to be a special form of a IgD-myeloma (20, 102). The immunochemical differences within the — μ, γ, α — are accompanied with specific clinical symptoms.
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The heavy chain disease is a “true” form of paraproteinemia. The existance of the μ, γ, and α heavy chain disease is well documented. The δ-type heavy chain seems to be a special form of a IgD-myeloma (20, 102). The immunochemical differences within the — μ, γ, α — are accompanied with specific clinical symptoms.
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The evolution of alpha heavy chain disease
The American Journal of Medicine, 1976Two patients with alpha heavy chain disease are described. In the first patient, treatment with cyclophosphamide, prednisone and doxycycline was associated with a 28 month-long remission and the disappearance of the paraprotein and lymphoplasmocytic infiltration of the intestine.
Martínez-Vázquez Jm +6 more
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Gastric Alpha Heavy Chain Disease
Oncology, 1987Clinicopathological and immunohistological features of 4 cases of gastric lymphomas with alpha-heavy chain disease (AHCD) are described. Clinically there were no reliable features that could distinguish them from the 'western' types of gastric lymphomas (WGL).
Y.T. Omar, M.F. Tungekar, K. Behbehani
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Diagnosis of Gamma Heavy-Chain Disease
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1981The diagnosis of gamma heavy-chain disease can be made only by immunochemical analysis of serum and urine. The case reported here demonstrates the importance of diligent observation of routine electrophoretic patterns, followed by immunoelectrophoresis where indicated for the identification of abnormal bands.
K R Hine +3 more
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The origin of light and heavy chains of immunoglobulins
Biochemical and Biophysical Research Communications, 1971Abstract A model is proposed for the origin of H chains of Ig by the translocation of vc1 gene for light chains to a c2c3 gene giving rise to a vc1c2c3 gene. This explains why the common part of H chain is three times longer than the variable part.
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Gamma Heavy Chain Disease. Where the Heavy Chains Arise
American Journal of Clinical Pathology, 1983William T. Pastuszak +3 more
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