Results 31 to 40 of about 4,061,678 (356)

Toxicity, mechanism and health effects of some heavy metals

Interdisciplinary Toxicology, 2014
Heavy metal toxicity has proven to be a major threat and there are several health risks associated with it. The toxic effects of these metals, even though they do not have any biological role, remain present in some or the other form harmful for the ...
Monisha Jaishankar, Tenzin Tseten, Naresh Anbalagan, B. Mathew, Krishnamurthy N. Beeregowda   +4 more
semanticscholar   +1 more source

Functional antibodies exhibit light chain coherence

bioRxiv, 2022
The vertebrate adaptive immune system modifies the genome of individual B cells to encode antibodies that bind particular antigens 1 . In most mammals, antibodies are composed of heavy and light chains that are generated sequentially by recombination of ...
D. Jaffe, Payam Shahi, Bruce A. Adams, Ashley M. Chrisman, Peter M. Finnegan, Nandhini Raman, Ariel E. Royall, Funien Tsai, Thomas Vollbrecht, Daniel S. Reyes, Wyatt J. McDonnell   +10 more
semanticscholar   +1 more source

Gamma heavy chain disease lacks the MYD88 L265p mutation associated with lymphoplasmacytic lymphoma

Haematologica, 2014
Gamma heavy chain disease (gHCD) is defined by an abnormally truncated IgG heavy chain monoclonal protein that lacks associated light chains and is secreted by a small B-cell neoplasm with plasmacytic differentiation.[1][1],[2][2] Clinically, gHCD is ...
F. Hamadeh, S. Macnamara, C. Bacon, A. Sohani, S. Swerdlow, J. Cook   +5 more
semanticscholar   +1 more source

Crystal Structure and Characterization of Human Heavy-Chain Only Antibodies Reveals a Novel, Stable Dimeric Structure Similar to Monoclonal Antibodies

Antibodies, 2020
We report the novel crystal structure and characterization of symmetrical, homodimeric humanized heavy-chain-only antibodies or dimers (HC2s). HC2s were found to be significantly coexpressed and secreted along with mAbs from transient CHO HC/LC ...
Carl Mieczkowski, Soheila Bahmanjah, Yao Yu, Jeanne Baker, Gopalan Raghunathan, Daniela Tomazela, Mark Hsieh, Mark McCoy, Corey Strickland, Laurence Fayadat-Dilman   +9 more
doaj   +1 more source

Sequence-Based Discovery Demonstrates That Fixed Light Chain Human Transgenic Rats Produce a Diverse Repertoire of Antigen-Specific Antibodies

Frontiers in Immunology, 2018
We created a novel transgenic rat that expresses human antibodies comprising a diverse repertoire of heavy chains with a single common rearranged kappa light chain (IgKV3-15-JK1).
Katherine E. Harris, Shelley Force Aldred, Laura M. Davison, Heather Anne N. Ogana, Andrew Boudreau, Marianne Brüggemann, Michael Osborn, Biao Ma, Benjamin Buelow, Starlynn C. Clarke, Kevin H. Dang, Suhasini Iyer, Brett Jorgensen, Duy T. Pham, Payal P. Pratap, Udaya S. Rangaswamy, Ute Schellenberger, Wim C. van Schooten, Harshad S. Ugamraj, Omid Vafa, Roland Buelow, Nathan D. Trinklein   +21 more
doaj   +1 more source

Regulation of motor activity of ciliary outer-arm dynein by the light chain 1; Implications from the structure of the light chain bound to the microtubule-binding domain of the heavy chain

Biophysics and Physicobiology, 2023
Ciliary bending movements are powered by motor protein axonemal dyneins. They are largely classified into two groups, inner-arm dynein and outer-arm dynein. Outer-arm dynein, which is important for the elevation of ciliary beat frequency, has three heavy
Toshiki Yagi, Akiyuki Toda, Muneyoshi Ichikawa, Genji Kurisu   +3 more
doaj   +1 more source

Data to understand the biotransfer of heavy metals along the soil-plant-edible insect-human food chain in Africa

Data in Brief, 2023
Data on the biotransfer of heavy metals along the soil-plant-edible insect-human food chain collected along a 60km pollution gradient is presented here.
Susan Mwelwa, Donald Chungu, Frank Tailoka, Dennis Beesigamukama, Chrysantus M. Tanga   +4 more
doaj   +1 more source

AL amyloidosis with non-amyloid forming monoclonal immunoglobulin deposition; a case mimicking AHL amyloidosis

BMC Nephrology, 2018
Background Immunoglobulin heavy-and-light-chain amyloidosis (AHL amyloidosis) is a newly established disease entity where both the immunoglobulin heavy-chain and light-chain compose amyloid fibrils. The immunoglobulins responsible for the amyloid fibrils
Shun Manabe, Chihiro Iwasaki, Michiyasu Hatano, Fuyuki Kametani, Masahide Yazaki, Kosaku Nitta, Michio Nagata   +6 more
doaj   +1 more source

Immunoglobulin heavy chain exclusion in the shark. [PDF]

PLoS Biology, 2008
The adaptive immune system depends on specific antigen receptors, immunoglobulins (Ig) in B lymphocytes and T cell receptors (TCR) in T lymphocytes.
Karolina Malecek, Victor Lee, Wendy Feng, Jing Li Huang, Martin F Flajnik, Yuko Ohta, Ellen Hsu   +6 more
doaj   +1 more source

AIRR-C IG Reference Sets: curated sets of immunoglobulin heavy and light chain germline genes

Frontiers in Immunology
IntroductionAnalysis of an individual’s immunoglobulin (IG) gene repertoire requires the use of high-quality germline gene reference sets. When sets only contain alleles supported by strong evidence, AIRR sequencing (AIRR-seq) data analysis is more ...
Andrew M. Collins, Mats Ohlin, Martin Corcoran, James M. Heather, James M. Heather, Duncan Ralph, Mansun Law, Jesus Martínez-Barnetche, Jian Ye, Eve Richardson, William S. Gibson, Oscar L. Rodriguez, Ayelet Peres, Gur Yaari, Corey T. Watson, William D. Lees, William D. Lees   +16 more
doaj   +1 more source