Results 41 to 50 of about 1,211,483 (357)

Early changes in rat diaphragm biology with mechanical ventilation [PDF]

, 2003
To better characterize the effects of 24-hour mechanical ventilation on diaphragm, the expression of myogenic transcription factors, myosin heavy chains, and sarcoplasmic/endoplasmic reticulum calcium-ATPase pumps was examined in rats.
Cadot, Pascal, De Paepe, Kristel, Decramer, Marc, Gayan-Ramirez, Ghislaine, Rácz, Gábor Z., Testelmans, Dries, Wuytack, Frank, Zádor, Ernő   +7 more
core   +1 more source

AIRR-C IG Reference Sets: curated sets of immunoglobulin heavy and light chain germline genes

Frontiers in Immunology
IntroductionAnalysis of an individual’s immunoglobulin (IG) gene repertoire requires the use of high-quality germline gene reference sets. When sets only contain alleles supported by strong evidence, AIRR sequencing (AIRR-seq) data analysis is more ...
Andrew M. Collins, Mats Ohlin, Martin Corcoran, James M. Heather, James M. Heather, Duncan Ralph, Mansun Law, Jesus Martínez-Barnetche, Jian Ye, Eve Richardson, William S. Gibson, Oscar L. Rodriguez, Ayelet Peres, Gur Yaari, Corey T. Watson, William D. Lees, William D. Lees   +16 more
doaj   +1 more source

Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells. [PDF]

, 1992
To understand the interactions between the microtubule-based motor protein kinesin and intracellular components, we have expressed the kinesin heavy chain and its different domains in CV-1 monkey kidney epithelial cells and examined their distributions ...
Bernstein, HD, Hom-Booher, N, McCaffrey, G, Navone, F, Niclas, J, Sparks, L, Vale, RD   +6 more
core  

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Diversity in the HLA-I Recognition of HLA-F Monoclonal Antibodies: HLA-F or HLA-Ib Monospecific, HLA-E or HLA-G Bispecific Antibodies with or without HLA-Ia Reactivity

Antibodies
Previous investigators have used various anti-HLA-F monoclonal antibodies (mAbs) to demonstrate that the tissue distribution of HLA-F is highly restricted. Notably, these mAbs differed in their immunodiagnostic capabilities.
Mepur H. Ravindranath, Narendranath M. Ravindranath, Carly J. Amato-Menker, Fatiha El Hilali, Edward J. Filippone   +4 more
doaj   +1 more source

Expansion of the preimmune antibody repertoire by junctional diversity in Bos taurus. [PDF]

PLoS ONE, 2014
Cattle have a limited range of immunoglobulin genes which are further diversified by antigen independent somatic hypermutation in fetuses. Junctional diversity generated during somatic recombination contributes to antibody diversity but its relative ...
Jenni Liljavirta, Mikael Niku, Tiina Pessa-Morikawa, Anna Ekman, Antti Iivanainen   +4 more
doaj   +1 more source

Whirling of a heavy chain [PDF]

, 1958
Approximate solutions are obtained for the non-linear problem of the forced whirling of a heavy chain. It is shown that for a given mode of whirling, triple valued solutions are obtained for speeds of rotation above the linear critical speed for that ...
Caughey, T. K.
core  

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

On the stability of rotating heavy chains

Journal of Differential Equations, 1979
AbstractThe object of this paper is two-fold. On the one hand we want to develop the duality theory for critical points which is introduced in [4]. The main result in this context is that if two critical points are in duality, and one of them is a local minimiser of its functional, then so is the other.
openaire   +3 more sources

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source