Single-domain antibodies and their formatting to combat viral infections [PDF]
, 2018 Since their discovery in the 1990s, single-domain antibodies (VHHs), also known as NanobodiesA (R), have changed the landscape of affinity reagents. The outstanding solubility, stability, and specificity of VHHs, as well as their small size, ease of ...
Ballegeer, Marlies +4 more
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SPG10 is a rare cause of spastic paraplegia in European families [PDF]
, 2008 Background: SPG10 is an autosomal dominant form of hereditary spastic paraplegia (HSP), which is caused by mutations in the neural kinesin heavy chain KIF5A gene, the neuronal motor of fast anterograde axonal transport.
Auer-Grumbach, M. +10 more
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A One Health Approach to Hypertrophic Cardiomyopathy. [PDF]
, 2017 Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease in humans and results in significant morbidity and mortality. Research over the past 25 years has contributed enormous insight into this inherited disease particularly in the ...
Stern, Joshua A, Ueda, Yu
core +1 more source
The network-level reproduction number and extinction threshold for vector-borne diseases [PDF]
arXiv, 2013 The reproduction number of deterministic models is an essential quantity to predict whether an epidemic will spread or die out. Thresholds for disease extinction contribute crucial knowledge on disease control, elimination, and mitigation of infectious diseases.
arxiv
Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss [PDF]
, 2005 This review on the role of neurofilaments as surrogate markers for axonal degeneration in neurological diseases provides a brief background to protein synthesis, assembly, function and degeneration.
Petzold, A
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Risk factors associated with chronic kidney disease of unknown origin (Ckdu) in North Central Province (NCP) of Sri Lanka: An analysis of evidence to date [PDF]
, 2020 © 2020 The Authors. Published by [Name of Publisher]. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://acquaintpublications.org ...
Aslam, Fahim
core
Function of B cells expressing a human immunoglobulin M rheumatoid factor autoantibody in transgenic mice. [PDF]
, 1993 We have generated transgenic mice that express the immunoglobulin (Ig)M heavy chain and kappa light chain genes coding for a human IgM rheumatoid factor (RF), Les.
Carson, DA +6 more
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Idiopathic nodular glomerulosclerosis in a chronic marijuana user; a case report and review of the literature [PDF]
, 2017 Background: Nodular glomerulosclerosis is a characteristic histological finding of diabetic nephropathy (DN) with thickened glomerular basement membrane (GBM) and hyalinized arterioles.
Abdul Salim, Sohil +3 more
core +2 more sources
Gamma heavy chain disease: a retrospective analysis of 6 cases. [PDF]
Orphanet J Rare Dis, 2023 Chang L, Zhou DB, Cao XX.
europepmc +1 more source
Cytomegalovirus prevents antigen presentation by blocking the transport of peptide-loaded major histocompatibility complex class I molecules into the medial-Golgi compartment [PDF]
, 1992 Selective expression of murine cytomegalovirus (MCMV) immediate-early (IE) genes leads to the presentation by the major histocompatibility complex (MHC) class I molecule L a of a peptide derived from MCMV IE protein pp89 (Reddehase, M. J., J.
Del Val, Margarita +6 more
core +2 more sources