Biomedicines, 2022 Heart failure (HF) is known as the final manifestation of cardiovascular diseases. Although cellular heterogeneity of the heart is well understood, the phenotypic transformation of cardiac cells in progress of HF remains obscure.
Luojiang Zhu +6 more
doaj +1 more source
Robust Bayesian Variable Selection for Gene-Environment Interactions [PDF]
, 2020 Gene-environment (G×E) interactions have important implications to elucidate the etiology of complex diseases beyond the main genetic and environmental effects.
Li, Xiaoxi, Ren, Jie, Wu, Cen, Zhou, Fei
core
γ Heavy Chain Disease in Man: cDNA Sequence Supports Partial Gene Deletion Model [PDF]
, 1982 Human gamma heavy chain disease (HCD) is characterized by the presence in serum of a short monoclonal Ig gamma chain unattached to light chains. Although most HCD proteins have internal deletions, in some the defect is NH2-terminal.
Alexander, Alice +6 more
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Function of B cells expressing a human immunoglobulin M rheumatoid factor autoantibody in transgenic mice. [PDF]
, 1993 We have generated transgenic mice that express the immunoglobulin (Ig)M heavy chain and kappa light chain genes coding for a human IgM rheumatoid factor (RF), Les.
Carson, DA +6 more
core +2 more sources
The peptide motif of the single dominantly expressed class I molecule of the chicken MHC can explain the response to a molecular defined vaccine of infectious bursal disease virus (IBDV) [PDF]
, 2013 In contrast to typical mammals, the chicken MHC (the BF-BL region of the B locus) has strong genetic associations with resistance and susceptibility to infectious pathogens as well as responses to vaccines.
Butter, Colin +4 more
core +1 more source
Molecular Genetics & Genomic Medicine, 2022 Background Myosin family genes, including those encoding myosin heavy chain 6, myosin heavy chain 7, myosin light chain 3, and myosin light chain 2 (MYL2), are important genetic factors in congenital heart disease (CHD).
Yunqian Zhang, Rui Peng, Hongyan Wang
doaj +1 more source
The Evolution of Our Understanding of Immunoproliferative Small Intestinal Disease (IPSID) over Time
Current Oncology, 2022 Immunoproliferative small intestinal disease (IPSID) is an uncommon disease with a higher prevalence in the developing world. IPSID diagnosis relies mainly on a tissue biopsy and a high index of suspicion.
Ruah AlYamany +4 more
doaj +1 more source
Prevalence of the E321G MYH1 variant for immune-mediated myositis and nonexertional rhabdomyolysis in performance subgroups of American Quarter Horses. [PDF]
, 2019 BackgroundImmune-mediated myositis (IMM) in American Quarter Horses (QHs) causes acute muscle atrophy and lymphocytic infiltration of myofibers. Recently, an E321G mutation in a highly conserved region of the myosin heavy chain 1 (MYH1) gene was ...
Finno, Carrie J +6 more
core +2 more sources
Heavy chain deposition disease in a case of clear cell renal cell carcinoma- A jack in the box
Indian Journal of Pathology and Microbiology, 2023 Renal cell carcinoma (RCC) is the most common subtype of adult renal tumors, and its detection rate in the early stages has been increased in the dawn of advanced imaging modalities.
Abhishek Kumar +6 more
doaj +1 more source
Heavy chain deposition disease presenting with raised anti-GBM antibody levels; a case report
BMC Nephrology, 2020 Background Monoclonal immunoglobulin deposition disease (MIDD) is a rare condition accounting for
Michael Turner +6 more
doaj +1 more source