Results 131 to 140 of about 87,769 (315)
Advanced Science, EarlyView.A dual‐function cell‐free therapeutic based on DC2.4 cell‐derived exosomes engineered to display BCMA. (Left) Soluble Ligand Sequestration (Decoy Function): DB Exo act as molecular decoys that predominantly sequester soluble APRIL with partial BAFF attenuation, effectively disrupting the NF‐κB survival signaling axis and suppressing myeloma cell ...
Yuqing Zeng +5 more
wiley +1 more source
Socio-cultural influences on vehicle defects in the Omani heavy vehicle industry [PDF]
, 2015 With recent economic growth in Oman there is increased use of heavy vehicles, presenting an increase in heavy vehicle crashes, associated fatalities and injuries.
Al-Maniri, Abdullah +5 more
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Oligopeptides/DNA Coacervate Droplets as Macromolecular Delivery Microcarriers
Advanced Science, EarlyView.Oligopeptide–DNA coacervates formed via liquid–liquid phase separation serve as programmable carriers for macromolecular cargos, entering cells through lipid raft–associated pathways and subsequently undergoing enzyme triggered intracellular disassembly driven by DNA degradation processes, thereby enabling efficient, controlled, and spatially defined ...
Linyi Zhang +5 more
wiley +1 more source
Roll- and pitch-plane-coupled hydro-pneumatic suspension. Part 2 dynamic response analyses [PDF]
, 2010 In the first part of this study, the potential performance benefits of fluidically coupled passive suspensions were demonstrated through analyses of suspension properties, design flexibility and feasibility.
Cao, Dongpu +2 more
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Advanced Science, EarlyView.The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao +8 more
wiley +1 more source
Improving directional stability control in a heavy truck by combining braking and steering action [Elektronisk resurs] [PDF]
, 2016 The introduction of electronics in heavy vehicle steering systems has enabled active steering torque support. As steering is an effective way of escaping directional instability and brakes are fast and decoupled from the driver a combination of ...
Pohl, Jochen, +5 more
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Advanced Science, EarlyView.Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv +13 more
wiley +1 more source
Wheel Speed Distribution Control and its Effect on Vehicle [PDF]
, 2007 The current work aims at bridging the gap between the current vehicle handling characteristics and the future demands of higher vehicle handling performance, required to guarantee higher safety and facilitate the application of autonomous driving ...
EI-Bayoumi, Mahmoud Attia M.
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Advanced Science, EarlyView.We identified a Krt14+ Igf2bp1+ bladder cancer population linked to EMT. Mechanistically, KRT14 stabilizes and transports IGF2BP1 to invasive protrusions, initiating a positive feedback loop that drives metastasis and poor outcomes. ABSTRACT Basal‐type muscle‐invasive bladder cancer (BMIBC) is characterized by aggressive metastasis and poor prognosis ...
Shirui Huang +19 more
wiley +1 more source
Vehicle Suspension Performance Analysis Based on Full Vehicle Model for Condition Monitoring Development [PDF]
The objective of this research is to develop a mathematical model using a seven degree-of-freedom full car. The simulation analyses were conducted to predict the response of the vehicle when driven across speed bumps of different shapes and at range of ...
Moamar, Hamed +3 more
core