Results 151 to 160 of about 87,769 (315)

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

Heavy Vehicle Crash Characteristics in Oman 2009-2011. [PDF]

Sultan Qaboos Univ Med J, 2015
Al-Bulushi I, Edwards J, Davey J, Armstrong K, Al-Reesi H, Al-Shamsi K.   +5 more
europepmc   +1 more source

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Optimizing a Sensor Network with Data from Hazard Mapping Demonstrated in a Heavy-Vehicle Manufacturing Facility. [PDF]

Ann Work Expo Health, 2018
Berman JD, Peters TM, Koehler KA.
europepmc   +1 more source

Coordination of Heavy-Duty Vehicle Platooning.

, 2018
Ett nätverksomfattande system för att koordinera körning i lastbilskolonner i syfte att minska bränsleförbrukningen utvecklas i denna avhandling.Vägtransport är med marginal det mest dominerande sättet för landtransport med en andel över 60 % i OECD-länderna och är således avgörande för samhällsekonomin.
openaire   +2 more sources

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

Twelve-hour before Driving Prevalence of Alcohol and Drug Use among Heavy Vehicle Drivers in South East of Iran Using Network Scale Up. [PDF]

Addict Health, 2019
Ahmadi-Gohari M, Zolala F, Iranpour A, Baneshi MR.   +3 more
europepmc   +1 more source

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

The World Latest Progress of Heavy Railway Transportation Technology

机车电传动, 2010
This paper described the definition and model of heavy transportation, from the world’s heavy railway transportation technology development point of view. The development of heavy railway in U.S.A, Canada, Australia, South Africa, Brazil, Sweden, Russia,
钱立新
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