Results 31 to 40 of about 404,238 (256)

Double-targeted liposomes coated with matrix metallopeptidase-2-responsive polypeptide nanogel for chemotherapy and enhanced immunotherapy against cervical cancer

Materials Today Bio
Immunotherapy is a cornerstone in cancer treatment, celebrated for its precision, ability to eliminate residual cancer cells, and potential to avert tumor recurrence. Nonetheless, its effectiveness is frequently undermined by the immunosuppressive milieu
Zhimin Bai, Yibo Yang, Zutong Cui, Wenming Liang, Xin Zhang, Zihan Zhang, Jianming Sun, Zhiwei Liu, Kun Li, Ming Shi, Jian Li   +10 more
doaj   +1 more source

Mixing efficacy and residence time distribution measurement in heavy water upgradation plant using radiotracer

Nuclear Engineering and Technology
To evaluate the efficiency of catalyst packing and to characterize the liquid phase flow dynamics in a heavy water distillation column, a series of residence time distribution (RTD) measurements were carried out using radiotracer.
Sunil Goswami, Saumyajeet Mukherjee, Sulabh Gupta, Jayashree Biswal, Rajesh Kumar, V.K. Sharma, Kalyan Bhanja, H.J. Pant, K.T. Shenoy   +8 more
doaj   +1 more source

Progress and Perspectives on Pyrite-Derived Materials Applied in Advanced Oxidation Processes for the Elimination of Emerging Contaminants from Wastewater

Molecules
Emerging contaminants (ECs) in wastewater threaten environmental and human health, while conventional methods often prove inadequate. This has driven increased concern among decision makers, justifying the need for innovative and effective treatment ...
Jannat Javed, Yuting Zhou, Saad Ullah, Tianjiu Gao, Caiyun Yang, Ying Han, Hao Wu   +6 more
doaj   +1 more source

Proof of Aerobically Autoxidized Self-Charge Concept Based on Single Catechol-Enriched Carbon Cathode Material

Nano-Micro Letters, 2023
Highlights An air-breathing chemical self-charge concept of oxygen-enriched carbon cathode. The oxygen-enriched carbon material with abundant catechol groups. Rapid air-oxidation chemical self-charge of catechol groups. Abstract The self-charging concept
Junyan Wang, Wanchun Guo, Kesong Tian, Xinta Li, Xinyu Wang, Panhua Li, Yu Zhang, Bosen Zhang, Biao Zhang, Shuhu Liu, Xueai Li, Zhaopeng Xu, Junjie Xu, Haiyan Wang, Yanglong Hou   +14 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Imaging Sub-Cellular Methionine and Insulin Interplay in Triple Negative Breast Cancer Lipid Droplet Metabolism

Frontiers in Oncology, 2022
Triple negative breast cancer (TNBC) is a particularly aggressive cancer subtype that is difficult to diagnose due to its discriminating epidemiology and obscure metabolome. For the first time, 3D spatial and chemometric analyses uncover the unique lipid
Anthony A. Fung, Khang Hoang, Honghao Zha, Derek Chen, Wenxu Zhang, Lingyan Shi   +5 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Defective Ultrathin ZnIn2S4 for Photoreductive Deuteration of Carbonyls Using D2O as the Deuterium Source

Advanced Science, 2022
Deuterium (D) labeling is of great value in organic synthesis, pharmaceutical industry, and materials science. However, the state‐of‐the‐art deuteration methods generally require noble metal catalysts, expensive deuterium sources, or harsh reaction ...
Chuang Han, Guanqun Han, Shukai Yao, Lan Yuan, Xingwu Liu, Zhi Cao, Arun Mannodi‐Kanakkithodi, Yujie Sun   +7 more
doaj   +1 more source