Results 41 to 50 of about 417,382 (265)

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Development and Characterization of Carbon‐Based Adsorbents Derived from Agricultural Wastes and Their Effectiveness in Adsorption of Heavy Metals in Waste Water [PDF]

, 2022
L. Natrayan, S. Kaliappan, Naga Dheeraj Kumar Reddy Chukka, M. Karthick, N. Sivakumar, Pravin P. Patil, S. Sekar, Subash Thanappan   +7 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

New Insights into Heavy Metal Sequestration Through Metal‐Phenolic Network‐Confined Nano‐HFO: Overlooking Iron Utilization and Modulating Electron Density

Advanced Science
Reducing toxic metal concentrations to trace levels remains a critical challenge in water remediation, largely due to the underutilization of hydrous ferric oxide (HFO), particularly within its inner layers. Herein, we present a novel strategy to enhance
Manyu Zhang, Xiaolin Du, Zhanqi Liu, Yujia Yang, Shuo Wang, Ningyi Chen, Yulin Wang, Yaran Song, Keju Sun, Qingrui Zhang   +9 more
doaj   +1 more source

Well-designed protein amyloid nanofibrils composites as versatile and sustainable materials for aquatic environment remediation: A review

Eco-Environment & Health, 2023
Amyloid nanofibrils (ANFs) are supramolecular polymers originally classified as pathological markers in various human degenerative diseases. However, in recent years, ANFs have garnered greater interest and are regarded as nature-based sustainable ...
Xiaolin Zhang, Mamitiana Roger Razanajatovo, Xuedong Du, Shuo Wang, Li Feng, Shunli Wan, Ningyi Chen, Qingrui Zhang   +7 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

FRACTIONATION OF HEAVY HYDROGEN ISOTOPES IN DYNAMICAL SYSTEMS

Геохімія техногенезу, 2019
The possibility of using mineral adsorbents for cleaning the moderator of heavy water reactors from tritium is determined. Three dynamic systems have been created using montmorilonite, sepiolite and palygorskite clays, and zeolite (systems M-Z, S-Z and P-
Pushkarov O. , Sevruk I. , Demihov Y., Dolin V.   +3 more
doaj   +1 more source

Preparation of graphene-carboxymethyl cellulose composite aerogel and evaluation of oil absorption performance

Cailiao gongcheng, 2022
With graphite oxide (GO) as the main raw material, combining with carboxymethyl cellulose (CMC), hydrothermal reduction combined ice template method was used to prepare graphene/carboxymethyl cellulose composite aerogel (HGA/CMC), through drying under ...
ZHANG Linlin, GU Xuelin, XIANG Xiaoxiao, LIU Huie, CHEN Shuang   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source