Results 151 to 160 of about 37,007 (262)

Long-Term Success in the Management of an Extensive Medial Canthal Basal-Cell Carcinoma with Vismodegib

Journal of Current Ophthalmology
Purpose: To present a case of an extensive basal-cell carcinoma (BCC) of the medial canthus that was successfully treated with vismodegib. The introduction of vismodegib and other Hedgehog pathway inhibitors into clinical practice has provided a new ...
Argyrios Tzamalis, Georgios Lavasidis, Ioannis Tsinopoulos, Nikolaos Ziakas   +3 more
doaj   +1 more source

Abstract 4818: The predictive value of a 5-gene signature as a patient pre-selection tool in medulloblastoma for Hedgehog pathway inhibitor therapy

, 2012
4818: The predictive value of a 5-gene signature as a patient pre-selection tool in medulloblastoma for Hedgehog pathway inhibitor ...
D Amakye (13667071), J Cho (6409904), D Ashley (12372034), A Thomas (841916), K Rose (13467516), D Robinson (9523037), T MacDonald (9209000), D Hargrave (13667089), M Casanova (13667092), R Bandaru (13667077), J Rodon (7806563), KL Ligon (9903048), B Geoerger (13667083), Y Ando (13667080), MW Kieran (15822125), F Doz (13667086), T Sharp (7704572), A Mita (13667095), A Haider (13667074)   +18 more
core  

Cortical‐Hypothalamic Assembloids Uncover the Cortical Regulation of Hypothalamic Responses to Fatty Acid

Cell Proliferation, EarlyView.
By assembling cortical‐hypothalamic circuits, we show that cortical input protects hypothalamic neurons from fatty acid‐induced damage, which activates PGC1α to boost mitochondrial function. This reveals a cortico‐hypothalamic axis that defends against metabolic stress.
Mengdan Tao, Xiaowen Du, Qi Chen, Wenxin Mu, Shuning Lou, Xu Zhang, Min Xu, Jiting Li, Yuxuan Guo, Wanying Zhu, Yan Liu   +10 more
wiley   +1 more source

The role of GLI2 in human basal cell carcinoma tumourigenesis

, 2010
PhDAbnormal Sonic Hedgehog (SHH) signalling leads to increased transcriptional activation of its downstream effector, GLI2, which is implicated in the pathogenesis of a variety of human tumours, including human basal cell carcinoma (BCC).
Pantazi, Eleni
core  

Mohs Surgery Outcomes for Basal Cell Carcinoma Treated With Neoadjuvant Sonic Hedgehog Inhibitor. [PDF]

Int J Dermatol
International Journal of Dermatology, Volume 65, Issue 7, Page 1493-1494, July 2026.
Barnawi G, Lazarowitz R, Aly S, Nukaly H, Weiss E.   +4 more
europepmc   +2 more sources

Thoughts on investigational hedgehog pathway inhibitors for the treatment of cancer [PDF]

Expert Opinion on Investigational Drugs, 2016
Tarkan, Jäger, Matthias, Ocker, Tobias, Kiesslich, Elen, Neureiter, Daniel, Neureiter   +4 more
openaire   +2 more sources

High Uric Acid Promotes Stem Leydig Cell Senescence by CCDC90B Mediates Mitochondrial Quality Control Imbalance

Cell Proliferation, EarlyView.
In hyperuricemia, uric acid inhibits CCDC90B ubiquitination degradation by binding to it. Excessive CCDC90B induces mitochondrial calcium overload, leading to mitochondrial quality control imbalance and ultimately resulting in SLC senescence and decreased testosterone levels.
Jiayu Huang, Ao Wang, Xiangyu Li, Peng Huang, Kaixuan Zeng, Lu Sun, Moxuan Li, Yixiang Chen, Jiancheng Wang   +8 more
wiley   +1 more source

Depicting the Immunological Landscape of Basal Cell Carcinoma Subtypes

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Anti‐PD‐1 response has been associated with higher PD‐1 ligand (PD‐L1) expression levels in different cancer types. Cemiplimab, an anti‐PD‐1 antibody, has been shown to induce a response rate of 31% and 22% in patients with locally advanced basal cell carcinoma (BCC) and metastatic BCC respectively, who have progressed or are ...
Isabella Dommann, Gaetana Restivo, Isabel Kolm, Federica Sella, Patrick Turko, Phil F. Cheng, Mitchell Levesque, Corina Dommann‐Scherrer, Reinhard Dummer, Egle Ramelyte   +9 more
wiley   +1 more source

New Tools for Target Deconvolution: Identifying BET Bromodomains as Hedgehog Pathway Inhibitor 1's Target

The Hedgehog (Hh) signaling pathway is pivotal for embryonic development of vertebrates and its abnormal activation can lead to tumorigenesis. The current Hh signaling pathway inhibitors target primarily upstream at the level of SMO and they suffer from ...
Bagka, Meropi
core   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source