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Recent advances in the design of Hedgehog pathway inhibitors for the treatment of malignancies
Expert Opinion on Drug Discovery, 2014The Hedgehog (Hh) signaling pathway is known to be dysregulated in several forms of cancer. Hence, specifically targeting this signaling cascade is a valid and promising strategy for successful therapeutic intervention. Several components within the Hh pathway have been proven to be druggable; however, challenges in the discovery and development ...
Upasana, Banerjee, Matthew Kyle, Hadden
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Inhibitors of the Hedgehog Signal Transduction Pathway
Current Cancer Therapy Reviews, 2005David Robbins +3 more
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Hedgehog pathway inhibitors come of age
British Journal of Dermatology, 2019openaire +2 more sources
Hedgehog Pathway Inhibitors for Periocular Basal Cell Carcinoma
International Ophthalmology Clinics, 2020Davin C, Ashraf, M Reza, Vagefi
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Multitarget hedgehog pathway inhibitors and uses thereof
2014The present invention concerns compds. that selectively inhibit the activity of the Hedgehog (Hh) pathway, their prepn. and uses thereof. The compds. of the present invention are useful in treating Hh-dependent tumors, such as medulloblastoma (MB).
BOTTA, Bruno +9 more
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Development of taladegib as a sonic hedgehog signaling pathway inhibitor
Archives of Pharmacal Research, 2017Guanghai Jin +2 more
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