Results 191 to 200 of about 4,870,076 (306)

Host determinants of exo-rAAV production revealed by extended gene expression analysis in HEK293 cells. [PDF]

Mol Ther Adv
Lavado-García J, Bosch-Molist L, Ruiz-Ayala C, Jorge I, Vázquez J, Gòdia F, Cervera L.   +6 more
europepmc   +1 more source

The Inflammasome Activity of NLRP3 Is Independent of NEK7 in HEK293 Cells Co-Expressing ASC. [PDF]

Int J Mol Sci, 2022
Machtens DA, Bresch IP, Eberhage J, Reubold TF, Eschenburg S.   +4 more
europepmc   +1 more source

Ferritin as a Nanoparticle Scaffold for Plant‐Produced Next‐Generation Subunit Vaccines

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Protein nanoparticles offer an innovative approach to next‐generation subunit vaccine development by displaying antigenic sequences on the nanoparticle surface. Compared to traditional subunit vaccines, protein nanoparticle vaccines often show improved interaction with the immune system due to their particulate size and repetitive epitope ...
Jordan T. VanderBurgt, Richard Strasser, Christopher P. Garnham, Rima Menassa   +3 more
wiley   +1 more source

Comparative Analysis of rAAV Production from Plasmid-Encoded Versus Chromosomally Integrated rAAV Transgene in HEK293 Cells. [PDF]

Int J Mol Sci
Toth M, Rempe A, Smesnik G, Reithofer M, Dürauer A, Grabherr R.   +5 more
europepmc   +1 more source

Hyperhalophilic Diatom Extract Protects against Lead-Induced Oxidative Stress in Rats and Human HepG2 and HEK293 Cells. [PDF]

Pharmaceuticals (Basel), 2023
Guermazi W, Boukhris S, Annabi-Trabelsi N, Rebai T, Sellami-Kamoun A, Aldahmash W, Plavan GI, Harrath AH, Ayadi H.   +8 more
europepmc   +1 more source

Enhancing Adeno‐Associated Virus 2 Capsid Engineering Through Co‐Evolutionary Coupling

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Adeno‐associated virus (AAV) has emerged as a leading platform for gene therapy. However, to unlock the full potential, their manufacturing yields, stability, and efficacy must all be improved. Rational design is limited by poor predictability and the potential impact of mutations on multiple important vector properties.
Sirimar Laosinwattana, Yiwen Li, Braulio Carrillo Sanchez, Ayesha Khan, Paul A. Dalby   +4 more
wiley   +1 more source

ZNF330/NOA36 interacts with HSPA1 and HSPA8 and modulates cell cycle and proliferation in response to heat shock in HEK293 cells. [PDF]

Biol Direct, 2023
Sanchez-Briñas A, Duran-Ruiz C, Astola A, Arroyo MM, Raposo FG, Valle A, Bolivar J.   +6 more
europepmc   +1 more source

Cell and Gene Therapies Manufacturing Challenges and Integrated Good Manufacturing Practices Solutions: A Lifecycle Perspective

Biotechnology and Bioengineering, EarlyView.
Lifecycle perspective on cell and gene therapy manufacturing challenges and enabling GMP solutions. ABSTRACT Cell and gene therapies (CGTs) are revolutionizing modern medicine; however, making these advanced medicines scalable and readily available to commercial manufacturers worldwide is a major challenge. The number of approved CGT products continues
Rajath Samaga, Udisha Singh, Sachin Dattram Pawar   +2 more
wiley   +1 more source

The Fatty Acid Transporter CD36 Mediates Uptake, Biodistribution, and Cardioprotection by Small Extracellular Vesicles From HEK293 Cells. [PDF]

J Extracell Vesicles
Sulaiman E, Yellon DM, Davidson SM.
europepmc   +1 more source

Generation of Gαi knock-out HEK293 cells illuminates Gαi-coupling diversity of GPCRs. [PDF]

Commun Biol, 2023
Ono Y, Kawakami K, Nakamura G, Ishida S, Aoki J, Inoue A.   +5 more
europepmc   +1 more source