5-(carbamoylmethylene)-oxazolidin-2-ones as a promising class of heterocycles inducing apoptosis triggered by increased ROS levels and mitochondrial dysfunction in breast and cervical cancer [PDF]
, 2020 Oxazolidinones are antibiotics that inhibit protein synthesis by binding the 50S ribosomal subunit. Recently, numerous worldwide researches focused on their properties and possible involvement in cancer therapy have been conducted.
Armentano, B +10 more
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Confirmation of Connexin45 Underlying Weak Gap Junctional Intercellular Coupling in HeLa Cells
Biomolecules, 2020 Gap junctions (GJs) are intercellular channels that connect adjacent cells electrically and metabolically. The iodide-yellow fluorescent protein (I-YFP) gap junctional intercellular communication (GJIC) assay is a recently developed method with high ...
Eun Ju Choi +3 more
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Nanomaterials, 2022 The study of the interaction of engineered nanoparticles, including quantum dots (QDs), with cellular constituents and the kinetics of their localization and transport, has provided new insights into their biological consequences in cancers and for the ...
Min Zhang +4 more
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Біологічні студії, 2022 Background. Various cationic polymers have been proposed for use as carriers of genetic materials in biotechnology and biomedicine. The poly(2-dimethylamino)ethyl-methacrylate (poly(DMAEMA)) demonstrated high transfection efficiency and low cytotoxicity ...
N. S. Finiuk +5 more
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Altered ganglioside GD3 in HeLa cells might influence the cytotoxic abilities of NK cells
Taiwanese Journal of Obstetrics & Gynecology, 2012 Objective: Previously, we found that altered sialidases in HeLa cells in a natural killer-HeLa (NK-HeLa) coculture system contributed to the decreased cytotoxic ability of NK cells.
Wen-Chi Lee +7 more
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Cool-associated Tyrosine-phosphorylated Protein 1 Is Required for the Anchorage-independent Growth of Cervical Carcinoma Cells by Binding Paxillin and Promoting AKT Activation. [PDF]
, 2017 Cool-associated tyrosine-phosphorylated protein 1 (Cat-1) is a signaling scaffold as well as an ADP-ribosylation factor-GTPase-activating protein. Although best known for its role in cell migration, we recently showed that the ability of Cat-1 to bind ...
Antonyak, Marc A. +3 more
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Cells, 2023 Pyruvate kinase M (PKM) 2 was described to interact with the inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) and suppress its activity. To further investigate the physiological importance of the PKM2:IP3R interaction, we developed and characterized ...
Fernanda O. Lemos +4 more
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WASH regulates the oxidative stress Nrf2/ARE pathway to inhibit proliferation and promote apoptosis of HeLa cells under the action of Jolkinolide B [PDF]
PeerJ, 2022 Jolkinolide B (JB), a diterpenoid compound isolated from the roots of Euphorbia fischeriana, has gained research attention for its antitumor effects. In recent years, JB reportedly displayed anti-tumor activity in solid tumors, such as breast, ovarian ...
Yu Hong +10 more
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Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1 [PDF]
, 2020 Cancer therapeutics: Extending a drug's reach A new drug that blocks heat shock proteins (HSPs), helper proteins that are co-opted by cancer cells to promote tumor growth, shows promise for cancer treatment.
Chae, Young Chan +10 more
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HeLa cells up-regulate Beclin1/autophagy pathway to confer resistance to doxorubicin
Di-san junyi daxue xuebao, 2019 Objective To investigate the role of doxorubicin (DOX) in the induction of protective autophagy in HeLa cells and explore the possible mechanism of DOX resistance.
GUO Yanjun, WANG Shuwei
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