Results 1 to 10 of about 162,084 (246)

The β-lactam adjuvant guanosine potentiates anti-folate antibiotics and pyrimidine synthesis inhibitors by depleting thymidine in methicillin-resistant Staphylococcus aureus [PDF]

Antimicrobial Agents and Chemotherapy
Efforts to improve the effectiveness of existing interventions for antimicrobial-resistant infections include identifying new ways to overcome resistance to licensed antibiotics using adjuvants or deploying antibiotics in novel combinations.
Aaron C. Nolan, Jessica B. Kelly, Jongsam Ahn, Dhananjay Shinde, Vinai C. Thomas, Merve S. Zeden, James P. O'Gara   +6 more
doaj   +2 more sources

Association of a Homozygous TYMP c.131G>C Variant With MNGIE in a Chinese Pedigree: Insights From Genetic Analysis and Computational Modeling [PDF]

Molecular Genetics & Genomic Medicine
Background Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive disorder caused by mutations in TYMP, which disrupt thymidine metabolism.
Ling Li, Xiu Chen, Hua Li, Kai Guo, Ting Zhang, Mingyi Ma, Songhua Zhao   +6 more
doaj   +2 more sources

α-Difluoromethylornithine-Induced Cytostasis is Reversed by Exogenous Polyamines, Not by Thymidine Supplementation

Biomolecules, 2021
Polyamine spermidine is essential for the proliferation of eukaryotic cells. Administration of polyamine biosynthesis inhibitor α-difluoromethylornithine (DFMO) induces cytostasis that occurs in two phases; the early phase which can be reversed by ...
Mervi T. Hyvönen, Maxim Khomutov, Jouko Vepsäläinen, Alex R. Khomutov, Tuomo A. Keinänen   +4 more
doaj   +1 more source

The Trypanosoma cruzi TcrNT2 Nucleoside Transporter Is a Conduit for the Uptake of 5-F-2′-Deoxyuridine and Tubercidin Analogues

Molecules, 2022
Among the scarce validated drug targets against Chagas disease (CD), caused by Trypanosoma cruzi, the parasite’s nucleoside salvage system has recently attracted considerable attention. Although the trypanocidal activity of tubercidin (7-deazapurine) has
Mustafa M. Aldfer, Ibrahim A. Alfayez, Hamza A. A. Elati, Nilanjana Gayen, Ehab Kotb Elmahallawy, Ana Milena Murillo, Sabrina Marsiccobetre, Serge Van Calenbergh, Ariel M. Silber, Harry P. de Koning   +9 more
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Molecular Basis of the Slow Growth of Mycoplasma hominis on Different Energy Sources

Frontiers in Cellular and Infection Microbiology, 2022
Mycoplasma hominis is an opportunistic urogenital pathogen in vertebrates. It is a non-glycolytic species that produces energy via arginine degradation. Among genital mycoplasmas, M.
Daria V. Evsyutina, Daria V. Evsyutina, Tatiana A. Semashko, Tatiana A. Semashko, Maria A. Galyamina, Sergey I. Kovalchuk, Rustam H. Ziganshin, Valentina G. Ladygina, Gleb Y. Fisunov, Gleb Y. Fisunov, Olga V. Pobeguts   +10 more
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Nanoparticles Based on Novel Carbohydrate-Functionalized Polymers

Molecules, 2020
Polymeric nanoparticles can be used for drug delivery systems in healthcare. For this purpose poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) offer an excellent polymeric matrix.
Cláudia D. Raposo, Cristiano A. Conceição, M. Teresa Barros   +2 more
doaj   +1 more source

Interaction of Thymidine with Sodium bis(2-ethylhexyl) Sulfosuccinate in Alcohol and Water: Studies with UV-Vis Technique

Pharmaceutical Sciences and Research, 2020
The accurate measurement of thymidine absorbance in the presence of sodium bis(2-ethylhexyl) sulfosuccinate (AOT) in ethanol and water systems at room temperature by UV-vis technique has been reported.
Indu M. Paudel, Ajaya Bhattarai
doaj   +1 more source

α-Tocopherol phosphate as a photosensitizer in the reaction of nucleosides with UV light: formation of 5,6-dihydrothymidine

Genes and Environment, 2022
Introduction α-Tocopherol phosphate, a natural water-soluble α-tocopherol analog, exists in biological tissues and fluids. Synthesized α-tocopherol phosphate is used as an ingredient of cosmetics.
Toshinori Suzuki, Chiaki Ono
doaj   +1 more source

Dexamethasone pretreatment impairs the thymidylate synthase inhibition mediated flare in thymidine salvage pathway activity in non-small cell lung cancer. [PDF]

PLoS ONE, 2018
INTRODUCTION:Successful inhibition of thymidylate synthase (TS) by pemetrexed, a TS inhibitor, results in a reproducible transient burst or "flare" in thymidine salvage pathway activity at 2 hrs.
Xiao Chen, Yizeng Yang, Sharyn I Katz
doaj   +1 more source

A critical examination of substoichiometric isotope dilution analysis using thymidine and leucine

Scientia Marina, 1999
Isotope dilution analysis is used to determine the specific activity of radiolabelled precursors such as 3H-thymidine and 3H-leucine incorporated into DNA or protein in environmental samples.
David F. Bird
doaj   +1 more source