Thymidine Catabolism as a Metabolic Strategy for Cancer Survival [PDF]
Cell Reports, 2017 Thymidine phosphorylase (TP), a rate-limiting enzyme in thymidine catabolism, plays a pivotal role in tumor progression; however, the mechanisms underlying this role are not fully understood.
Sho Tabata +20 more
doaj +6 more sources
Thymidine Phosphorylase in Cancer; Enemy or Friend? [PDF]
Cancer Microenvironment, 2016 Thymidine phosphorylase (TP) is a nucleoside metabolism enzyme that plays an important role in the pyrimidine pathway.TP catalyzes the conversion of thymidine to thymine and 2-deoxy-α-D-ribose-1-phosphate (dRib-1-P). Although this reaction is reversible,
Yasir Y. Elamin +4 more
semanticscholar +2 more sources
Unchanged thymidine triphosphate pools and thymidine metabolism in two lines of thymidine kinase 2‐mutated fibroblasts [PDF]
The FEBS Journal, 2009 Mitochondrial thymidine kinase (TK2) catalyzes the phosphorylation of thymidine in mitochondria. Its function becomes essential for dTTP synthesis in noncycling cells, where cytosolic dTTP synthesis via R1/R2 ribonucleotide reductase and thymidine kinase 1 is turned down.
FRANGINI, MIRIAM +6 more
openaire +4 more sources
Accumulation of thymidine-derived sugars in thymidine phosphorylase overexpressing cells [PDF]
Biochemical Pharmacology, 2010 Thymidine phosphorylase (TP) is often overexpressed in cancer and potentially plays a role in the stimulation of angiogenesis. The exact mechanism of angiogenesis induction is unclear, but is postulated to be related to thymidine-derived sugars. TP catalyzes the conversion of thymidine (TdR) to thymine and deoxyribose-1-phosphate (dR-1-P), which can be
Bijnsdorp, I.V. +8 more
openaire +9 more sources
Thymidine nucleotide metabolism controls human telomere length
Nature Genetics, 2023 Telomere length in humans is associated with lifespan and severe diseases, yet the genetic determinants of telomere length remain incompletely defined.
W. Mannherz, Suneet Agarwal
semanticscholar +1 more source
Synthesis of 5′-Thymidine-Conjugated Formylphenylboronic Acids as Potential Lysine Targeting Iminoboronate Reversible Covalent Enzyme Probes [PDF]
, 2022 The design of reversible-covalent molecules to selectively target the ε-amino functionality of lysine residues in enzymes or proteins is a highly desirable goal.
Katherine N. Robertson (841910) +6 more
core +1 more source
Thymidine Kinase-Independent Click Chemistry DNADetect Probes for DNA Proliferation Assessment in Malaria Parasites [PDF]
, 2023 Metabolic chemical probes are small-molecule reagents that utilize naturally occurring biosynthetic enzymes for in situ incorporation into biomolecules of interest.
Hilko, David +4 more
core +1 more source
Thymidine uptake, thymidine incorporation, and thymidine kinase activity in marine bacterium isolates [PDF]
Applied and Environmental Microbiology, 1990 One assumption made in bacterial production estimates from [3H]thymidine incorporation is that all heterotrophic bacteria can incorporate exogenous thymidine into DNA. Heterotrophic marine bacterium isolates from Tampa Bay, Fla., Chesapeake Bay, Md., and a coral surface microlayer were examined for thymidine uptake (transport), thymidine incorporation,
W H, Jeffrey, J H, Paul
openaire +2 more sources
Altered Thymidine Metabolism Due to Defects of Thymidine Phosphorylase [PDF]
Journal of Biological Chemistry, 2002 Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive human disease due to mutations in the thymidine phosphorylase (TP) gene. TP enzyme catalyzes the reversible phosphorolysis of thymidine to thymine and 2-deoxy-D-ribose 1-phosphate. We present evidence that thymidine metabolism is altered in MNGIE.
SPINAZZOLA A +10 more
openaire +6 more sources
Thymidine kinase 1 through the ages: a comprehensive review
Cell & Bioscience, 2020 Proliferation markers, such as proliferating cell nuclear antigen (PCNA), Ki-67, and thymidine kinase 1 (TK1), have potential as diagnostic tools and as prognostic factors in assessing cancer treatment and disease progression. TK1 is involved in cellular
Eliza E. Bitter +4 more
semanticscholar +1 more source