Results 11 to 20 of about 151,356 (287)

Thymidine Catabolism as a Metabolic Strategy for Cancer Survival [PDF]

Cell Reports, 2017
Thymidine phosphorylase (TP), a rate-limiting enzyme in thymidine catabolism, plays a pivotal role in tumor progression; however, the mechanisms underlying this role are not fully understood.
Sho Tabata, Masatatsu Yamamoto, Hisatsugu Goto, Akiyoshi Hirayama, Maki Ohishi, Takuya Kuramoto, Atsushi Mitsuhashi, Ryuji Ikeda, Misako Haraguchi, Kohichi Kawahara, Yoshinari Shinsato, Kentaro Minami, Atsuro Saijo, Masaki Hanibuchi, Yasuhiko Nishioka, Saburo Sone, Hiroyasu Esumi, Masaru Tomita, Tomoyoshi Soga, Tatsuhiko Furukawa, Shin-ichi Akiyama   +20 more
doaj   +3 more sources

Accumulation of thymidine-derived sugars in thymidine phosphorylase overexpressing cells [PDF]

Biochemical Pharmacology, 2010
Thymidine phosphorylase (TP) is often overexpressed in cancer and potentially plays a role in the stimulation of angiogenesis. The exact mechanism of angiogenesis induction is unclear, but is postulated to be related to thymidine-derived sugars. TP catalyzes the conversion of thymidine (TdR) to thymine and deoxyribose-1-phosphate (dR-1-P), which can be
Bijnsdorp, I.V., Azijli, K., Jansen, E.E.W., Wamelink, M.M.C., Jakobs, C., Struijs, E.A., Fukushima, M, Kruyt, F.A.E., Peters, G.J.   +8 more
openaire   +8 more sources

A sulfur-containing nucleoside antibiotic from Photorhabdus [PDF]

mBio
We report the discovery of 4′-thiothymidine (4′sT), a sulfur-containing nucleoside antibiotic produced by the nematode symbiont Photorhabdus asymbiotica.
Sangkeun Son, Negar Shahsavari, Thomas Privalsky, Bryson A. Hawkins, Mi-Hyun Lee, Norman Pitt, Akira Iinishi, Raleb Taher, Nikita Gupta, Chandra Sekar Shankar, Jaini Patel, Kim Lewis   +11 more
doaj   +2 more sources

Pathways of thymidine hypermodification [PDF]

Nucleic Acids Research, 2021
Abstract The DNAs of bacterial viruses are known to contain diverse, chemically complex modifications to thymidine that protect them from the endonuclease-based defenses of their cellular hosts, but whose biosynthetic origins are enigmatic.
Yan-Jiun Lee, Nan Dai, Stephanie I Müller, Chudi Guan, Mackenzie J Parker, Morgan E Fraser, Shannon E Walsh, Janani Sridar, Andrew Mulholland, Krutika Nayak, Zhiyi Sun, Yu-Cheng Lin, Donald G Comb, Katherine Marks, Reyaz Gonzalez, Daniel P Dowling, Vahe Bandarian, Lana Saleh, Ivan R Corrêa, Peter R Weigele   +19 more
openaire   +2 more sources

α-Difluoromethylornithine-Induced Cytostasis is Reversed by Exogenous Polyamines, Not by Thymidine Supplementation

Biomolecules, 2021
Polyamine spermidine is essential for the proliferation of eukaryotic cells. Administration of polyamine biosynthesis inhibitor α-difluoromethylornithine (DFMO) induces cytostasis that occurs in two phases; the early phase which can be reversed by ...
Mervi T. Hyvönen, Maxim Khomutov, Jouko Vepsäläinen, Alex R. Khomutov, Tuomo A. Keinänen   +4 more
doaj   +1 more source

The Trypanosoma cruzi TcrNT2 Nucleoside Transporter Is a Conduit for the Uptake of 5-F-2′-Deoxyuridine and Tubercidin Analogues

Molecules, 2022
Among the scarce validated drug targets against Chagas disease (CD), caused by Trypanosoma cruzi, the parasite’s nucleoside salvage system has recently attracted considerable attention. Although the trypanocidal activity of tubercidin (7-deazapurine) has
Mustafa M. Aldfer, Ibrahim A. Alfayez, Hamza A. A. Elati, Nilanjana Gayen, Ehab Kotb Elmahallawy, Ana Milena Murillo, Sabrina Marsiccobetre, Serge Van Calenbergh, Ariel M. Silber, Harry P. de Koning   +9 more
doaj   +1 more source

Molecular Basis of the Slow Growth of Mycoplasma hominis on Different Energy Sources

Frontiers in Cellular and Infection Microbiology, 2022
Mycoplasma hominis is an opportunistic urogenital pathogen in vertebrates. It is a non-glycolytic species that produces energy via arginine degradation. Among genital mycoplasmas, M.
Daria V. Evsyutina, Daria V. Evsyutina, Tatiana A. Semashko, Tatiana A. Semashko, Maria A. Galyamina, Sergey I. Kovalchuk, Rustam H. Ziganshin, Valentina G. Ladygina, Gleb Y. Fisunov, Gleb Y. Fisunov, Olga V. Pobeguts   +10 more
doaj   +1 more source

Thymidine plaque autoradiography of thymidine kinase-positive and thymidine kinase-negative herpesviruses [PDF]

Journal of Clinical Microbiology, 1983
Plaques formed by herpes simplex virus (HSV), pseudorabies virus, and varicella-zoster virus were studied by plaque autoradiography after [14C]thymidine labeling. Standard thymidine kinase-positive (TK+) viruses and TK- mutants of HSV types 1 and 2 and pseudorabies virus were studied, including cell cultured viruses and viruses isolated from animals ...
R B, Tenser, J C, Jones, S J, Ressel, F A, Fralish   +3 more
openaire   +2 more sources

Nanoparticles Based on Novel Carbohydrate-Functionalized Polymers

Molecules, 2020
Polymeric nanoparticles can be used for drug delivery systems in healthcare. For this purpose poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) offer an excellent polymeric matrix.
Cláudia D. Raposo, Cristiano A. Conceição, M. Teresa Barros   +2 more
doaj   +1 more source

Thymidine uptake, thymidine incorporation, and thymidine kinase activity in marine bacterium isolates [PDF]

Applied and Environmental Microbiology, 1990
One assumption made in bacterial production estimates from [3H]thymidine incorporation is that all heterotrophic bacteria can incorporate exogenous thymidine into DNA. Heterotrophic marine bacterium isolates from Tampa Bay, Fla., Chesapeake Bay, Md., and a coral surface microlayer were examined for thymidine uptake (transport), thymidine incorporation,
W H, Jeffrey, J H, Paul
openaire   +2 more sources