Results 21 to 30 of about 162,084 (246)

Optimisation of the lymphocyte proliferation assay in rainbow trout (Oncorhynchus mykiss)

Veterinární Medicína, 2019
The lymphocyte proliferation assay is a valuable method used for the evaluation of the fish immune system. However, there are many variations and optimal results are not always obtained.
Hana Minarova, Miroslava Palikova, Jan Mares, Eva Syrova, Jana Blahova, Martin Faldyna, Petra Ondrackova   +6 more
doaj   +1 more source

Fission yeast strains with circular chromosomes require the 9-1-1 checkpoint complex for the viability in response to the anti-cancer drug 5-fluorodeoxyuridine. [PDF]

PLoS ONE, 2017
Thymidine kinase converts 5-fluorodeoxyuridine to 5-fluorodeoxyuridine monophosphate, which causes disruption of deoxynucleotide triphosphate ratios.
Hossain Mohammad Shamim, Yukako Minami, Daiki Tanaka, Shinobu Ukimori, Johanne M Murray, Masaru Ueno   +5 more
doaj   +1 more source

Can plasma antioxidants prevent DNA damage in oxidative stress condition induced by growth hormone deficiency? A pilot study.

PLoS ONE, 2021
Adult growth hormone deficiency (GHD), a condition characterized by increased oxidative stress, is related to augmented cardiovascular, metabolic and oncological risk. A case-control observational study has been performed to evaluate DNA oxidative damage
Antonio Mancini, Francesco Guidi, Carmine Bruno, Flavia Angelini, Edoardo Vergani, Paola Lanza, Alvaro Mordente, Elisabetta Meucci, Andrea Silvestrini   +8 more
doaj   +1 more source

Hydrogen Peroxide-Induced Thymidine Incorporation Into Cultured Rat Astrocytes

Journal of Pharmacological Sciences, 2006
We characterized [methyl-3H]thymidine ([3H]thymidine) and [5-3H]uridine ([3H]uridine) incorporation into cultured astrocytes and neurons in the presence and absence of hydrogen peroxide (H2O2) in order to define the response to oxidative stress in the ...
Koh-ichi Tanaka, Tomoaki Sato, Yoshiko Ohnishi, Takashige Nishikawa   +3 more
doaj   +1 more source

Validation of an Immunoassay for Anti-thymidine Phosphorylase Antibodies in Patients with MNGIE Treated with Enzyme Replacement Therapy

Molecular Therapy: Methods & Clinical Development, 2018
Erythrocyte encapsulated thymidine phosphorylase is recombinant Escherichia coli thymidine phosphorylase encapsulated within human autologous erythrocytes and is under development as an enzyme replacement therapy for the ultra-rare inherited metabolic ...
Michelle Levene, Dario Pacitti, Charlotte Gasson, Jamie Hall, Marcia Sellos-Moura, Bridget E. Bax   +5 more
doaj   +1 more source

The effect of fluoropyrimidines with or without thymidine phosphorylase inhibitor on the expression of thymidine phosphorylase

, 2004
Thymidine phosphorylase (platelet-derived-endothelial-cell-growth-factor) catalyzes the reversible phosphorolysis of thymidine to thymine and 2-deoxyribose-1-phosphate, activates 5′-deoxy-5-fluorouridine (5′DFUR) and inactivates trifluorothymidine (TFT).
Van Capel, Toni, Pinedo, Herbert M., Hoekman, Klaas, De Bruin, Michiel, Smid, Kees, Peters, Godefridus J., Fukushima, Masakazu   +6 more
core   +2 more sources

Incorporation of thymidine into onion root meristematic cell nuclei in presence of hydroxyurea and its role in recovery of mitotic activity

Acta Societatis Botanicorum Poloniae, 2015
Hydroxyurea treatment of onion roots induced mitotic block which was released by transfer of bulbs to water, and also to some extent by addition of cold or 3H-thymidine to hydroxyurea solutions.
H. Habdas
doaj   +1 more source

Inhibitory Effect of Bridged Nucleosides on Thermus aquaticus DNA Polymerase and Insight into the Binding Interactions. [PDF]

PLoS ONE, 2016
Modified nucleosides have the potential to inhibit DNA polymerases for the treatment of viral infections and cancer. With the hope of developing potent drug candidates by the modification of the 2',4'-position of the ribose with the inclusion of a bridge,
Sung-Kun Kim, Aaron Castro, Edward S Kim, Austin P Dinkel, Xiaoyun Liu, Miguel Castro   +5 more
doaj   +1 more source

Comparison of [3H]-Thymidine, Carboxyfluorescein Diacetate Succinimidyl Ester and Ki-67 in Lymphocyte Proliferation

Frontiers in Pediatrics, 2022
BackgroundPatients with T cell deficiency <10% of normal proliferation are indicated to receive immune reconstruction by hematopoietic stem cell transplantation (HSCT).
Hsin-Ju Lee, Chun-Chun Gau, Chun-Chun Gau, Chun-Chun Gau, Wan-Fang Lee, Wen-I Lee, Wen-I Lee, Jing-Long Huang, Jing-Long Huang, Jing-Long Huang, Shih-Hsiang Chen, Ho-Yu Yeh, Chi-Jou Liang, Shih-Hang Fu   +13 more
doaj   +1 more source

Thymidine exerts anti-doxorubicin-induced cardiomyopathy effect through the regulation of the PPAR signaling pathways and ferroptosis pathways

Frontiers in Pharmacology
IntroductionTo evaluate the anti-cardiomyopathic activity of thymine (Thy) and to elucidate its mechanism of action.MethodsTransgenic zebrafish with enhanced green fluorescent protein (EGFP)-labelled hearts (Tg (cmlc2: EGFP)) and wild-type AB zebrafish ...
Bin Li, Bin Li, Qifei Wang, Qifei Wang, Jiashuo Zhou, Jiashuo Zhou, Peihai Li, Peihai Li, Chen Sun, Chen Sun, Qing Xia, Qing Xia, Yun Zhang, Yun Zhang   +13 more
doaj   +1 more source