Results 231 to 240 of about 10,441,214 (290)
Nanoparticles Functionalized with Polymer Brushes for Gene Delivery
Advanced NanoBiomed Research, EarlyView.The engineering of the next generation gene delivery vectors requires the precise control of the architecture and physicochemical interactions controlling the transport, targeting, uptake, and release of nucleic acid materials to targeted cells. Polymer brush‐functionalized nanomaterials offer unprecedented control over such design and properties, and ...
Carlos E. Neri‐Cruz, Julien E. Gautrot
wiley +1 more source
Imaging‐Based High‐Content Screening with Clickable Probes Identifies XPB Inhibitors
Angewandte Chemie, EarlyView.Our study introduces TL‐alkyne as an innovative tool for bio‐orthogonal labeling of endogenous XPB in live cells, facilitating the creation of a cell‐based imaging HCS assay. This platform not only enabled the identification of pelitinib as a novel XPB inhibitor but also demonstrated its potential to improve cancer treatment through synergistic effects
Shuqi Li +10 more
wiley +2 more sources
Angewandte Chemie, EarlyView.Die Bioreversible Arginin‐Modifikation aminhaltiger Proteinreste (BioRAM) ermöglicht eine serumkompatible, leicht zugängliche und effiziente Einschleusung nativer Proteine in lebende Zellen. In Kombination mit zellpenetrierenden Peptid‐Additiven führt BioRAM zu nanomolarer intrazellulären RNase‐A‐Aktivität und erlaubt so den zellulären Transport ...
Jonathan Franke +3 more
wiley +1 more source
Angewandte Chemie, EarlyView.We introduce two methods for incorporating carbazolyl cyanobenzenes onto peptides: a C‐terminus decarboxylative functionalization and a Cys‐selective SNAr reaction. Both conjugates exhibit excellent photoredox/energy‐transfer properties, enabling their use for C‐terminal alkynylation and Cys‐selective thiol‐ene reactions on peptides, as well as ...
Xing‐Yu Liu +4 more
wiley +1 more source
Water‐Soluble Molecular Wires for Membrane Potential Imaging
Angewandte Chemie, EarlyView.Fully water‐soluble fluorescent rosamine‐based amphiphilic molecular wires were developed for imaging membrane potentials. The performance of the probes was evaluated in single cardiomyocytes, murine pituitary gland, and islets of Langerhans.
Mirna El Khatib +9 more
wiley +1 more source
Communicative Nanomotors Reprogram Cancer Cell Death via Pyroptosis
Angewandte Chemie, EarlyView.Communicative nanomotors respond to elevated ROS in the tumor microenvironment, enabling active communication and selective mitochondrial targeting through non‐covalent surface engineering. Their precise interaction with cells induces mitochondrial damage, cytochrome c release, and pyroptotic cell death, while chemotactic motility ensures deeper tumor ...
Mingchen Sun +3 more
wiley +1 more source
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Synchronization of HeLa Cells.
Methods in molecular biology, 2017HeLa is one of the oldest and most commonly used cell lines in biomedical research. Owing to the ease of which they can be effectively synchronized by various methods, HeLa cells have been used extensively for studying the cell cycle. Here, we describe several protocols for synchronizing HeLa cells from different phases of the cell cycle, including G1 ...
H. Ma, R. Poon
semanticscholar +7 more sources
2022
HeLa cells were embedded in Durcupan and observed with a Serial Block Face Scanning Electron Microscope (SBF SEM) following the National Centre for Microscopy and Imaging Research (NCMIR) protocol. The images were acquired with an SBF SEM 3View2XP microscope (Gatan, Pleasanton, CA, USA) attached to a Sigma VP SEM (Zeiss, Cambridge, UK).
Karabag, Cefa +1 more
openaire +1 more source
HeLa cells were embedded in Durcupan and observed with a Serial Block Face Scanning Electron Microscope (SBF SEM) following the National Centre for Microscopy and Imaging Research (NCMIR) protocol. The images were acquired with an SBF SEM 3View2XP microscope (Gatan, Pleasanton, CA, USA) attached to a Sigma VP SEM (Zeiss, Cambridge, UK).
Karabag, Cefa +1 more
openaire +1 more source