Results 61 to 70 of about 353,465 (231)

Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules [PDF]

, 2017
Tubulin-targeting molecules are widely used cancer therapeutic agents. They inhibit microtubule-based structures, including the mitotic spindle, ultimately preventing cell division.
Coluccia, Antonio, Cundari, Enrico, DI CESARE, Erica, Famiglini, Valeria, Giubettini, Maria, LA REGINA, Giuseppe, Lavia, Patrizia, Miele, Andrea, Rovella, Paola, Silvestri, Romano, Verrico, Annalisa   +10 more
core   +1 more source

Lipid Nanoparticle‐Mediated CRISPR‐Cas13a Delivery for the Control of Bacterial Infection

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
New formulations of lipid nanoparticles (LNPs) that can deliver nucleic acids to Gram‐negative bacteria are proposed to combat bacterial infection. The delivery of nucleic acids by LNPs is aided by LNP‐helpers which weaken the bacterial outer membrane. LNPs encapsulating the Cas13a/gRNA expression vector achieve an antibacterial effect in both in vivo ...
Bookun Kim, Hwi Won Seo, Kyuri Lee, Dongeun Yong, Yoon Kyung Park, Yujin Lee, Solip Lee, Do‐Wan Kim, Dajeong Kim, Choong‐Min Ryu   +9 more
wiley   +1 more source

Cytotoxicity of the Bacillus thuringiensis Crystal Protein against Mammalian Cells [PDF]

, 2002
The crystal proteins produced by Bacillus thuringiensis subsp, israelensis (Bti) and subsp. coreanensis A1519 strain were examined for the cytotoxicity against MOLT-4 and HeLa cells by MTT assay and LDH assay, The A1519 crystal proteins processed by ...
Akao, Tetsuyuki, Mizuki, Eiichi, Namba, Akitoshi, Ohba, Michio, Sakai, Hiroshi, Yamagiwa, Masashi   +5 more
core   +1 more source

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

Exosomes are natural carriers of exogenous siRNA to human cells in vitro [PDF]

, 2013
© 2013 Shtam et al. Background: Exosomes are nano-sized vesicles of endocytic origin that are involved in cell-to-cell communication including shuttle RNA, mainly mRNA and microRNA.
Filatov, MV, Kil, YV, Kovalev, RA, Makarov, EM, Shtam, TA, Varfolomeeva, EY   +5 more
core   +1 more source

State‐of‐the‐Art, Insights, and Perspectives for MOFs‐Nanocomposites and MOF‐Derived (Nano)Materials

Advanced Materials, EarlyView.
Different approaches to MOF‐NP composite formation, such as ship‐in‐a‐bottle, bottle‐around‐the‐ship and in situ one‐step synthesis, are used. Owing to synergistic effects, the advantageous features of the components of the composites are beneficially combined, and their individual drawbacks are mitigated.
Stefanos Mourdikoudis, Subhajit Dutta, Saqib Kamal, Sergio Gómez‐Graña, Isabel Pastoriza‐Santos, Stefan Wuttke, Lakshminarayana Polavarapu   +6 more
wiley   +1 more source

A new potential radiosensitizer: ammonium persulfate modified WCNTs [PDF]

, 2007
Radiotherapy plays a very important role in cancer treatment. Radiosensitizers have been widely used to enhance the radiosensitivity of cancer cells at given radiations.
Bo-Zhang Yu, Jian-She Yang, Wen-Xin Li
core   +1 more source

Cisternal Organization of the Endoplasmic Reticulum during Mitosis [PDF]

, 2009
The endoplasmic reticulum (ER) of animal cells is a single, dynamic, and continuous membrane network of interconnected cisternae and tubules spread out throughout the cytosol in direct contact with the nuclear envelope.
Adam Linstedt, Anderson D. J., Baumann O., Beaudouin J., Bobinnec Y., Boucrot E., Du Y., Ellenberg J., Ferko M. C., Fricker M., Hu J., Jesch S. A., Kremer J. R., Lei Lu, Mark S. Ladinsky, Mastronarde D. N., Mastronarde D. N., McCullough S., Ostlund C, Puhka M., Saffarian S., Shibata Y., Shibata Y., Terasaki M., Tom Kirchhausen, Voeltz G. K., Voeltz G. K., Waterman-Storer C. M., Yang L., Zhai Y.   +29 more
core   +3 more sources

Upconversion Nanoparticle‐Covalent Organic Framework Core–shell Particles as Therapeutic Microrobots Trackable With Optoacoustic Imaging

Advanced Materials, EarlyView.
Upconversion nanoparticle‐covalent organic framework core–shell particles provide enhanced contrast for optoacoustic imaging by leveraging the optical absorption of upconversion luminescence within the covalent organic framework matrix. Beyond their role as contrast agents, these particles enable customizable therapeutic agent loading and release, as ...
Dong Wook Kim, Paul Wrede, Andrés Rodríguez‐Camargo, Yi Chen, Nihal Olcay Dogan, Chaim Glück, Bettina V. Lotsch, Daniel Razansky, Metin Sitti   +8 more
wiley   +1 more source

DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications

Advanced Materials, EarlyView.
DNA‐directed assembly offers a powerful strategy for constructing structured photonic nanomaterials with precise spatial control. This review provides a comprehensive overview of recent advancements in DNA‐assembled photonic nanomaterials for diagnostics and therapeutics, highlighting key design principles, functionalization strategies, and optical ...
Longjiang Ding, Bing Liu, Andreas Peil, Sisi Fan, Jie Chao, Na Liu   +5 more
wiley   +1 more source