Mini-chromosome maintenance complexes form a filament to remodel DNA structure and topology. [PDF]
, 2013 Deregulation of mini-chromosome maintenance (MCM) proteins is associated with genomic instability and cancer. MCM complexes are recruited to replication origins for genome duplication.
Brewster, Aaron +7 more
core +1 more source
Dissociation of Rad51 Presynaptic Complexes and Heteroduplex DNA Joints by Tandem Assemblies of Srs2
Cell Reports, 2017 Srs2 is a superfamily 1 (SF1) helicase and antirecombinase that is required for genome integrity. However, the mechanisms that regulate Srs2 remain poorly understood.
Kyle Kaniecki +5 more
doaj +1 more source
The Human Replicative Helicase, the CMG Complex, as a Target for Anti-cancer Therapy
Frontiers in Molecular Biosciences, 2018 DNA helicases unwind or rearrange duplex DNA during replication, recombination and repair. Helicases of many pathogenic organisms such as viruses, bacteria, and protozoa have been studied as potential therapeutic targets to treat infectious diseases, and
Y. Seo, Young-Hoon Kang
semanticscholar +1 more source
“Breaking up is hard to do”: the formation and resolution of sister chromatid intertwines [PDF]
, 2014 The absolute necessity to resolve every intertwine between the two strands of the DNA double helix provides a massive challenge to the cellular processes that duplicate and segregate chromosomes.
Bartkova +110 more
core +1 more source
Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate
Nature Communications, 2016 The Cdc45-MCM-GINS (CMG) helicase unwinds DNA during the elongation step of eukaryotic genome duplication and this process depends on the MCM ATPase function.
F. Abid Ali +7 more
semanticscholar +1 more source
Mutations in Mtr4 Structural Domains Reveal Their Important Role in Regulating tRNA\u3csub\u3ei\u3c/sub\u3e \u3csup\u3eMet\u3c/sup\u3e Turnover in \u3cem\u3eSaccharomyces cerevisiae\u3c/em\u3e and Mtr4p Enzymatic Activities \u3cem\u3eIn Vitro\u3c/em\u3e [PDF]
, 2016 RNA processing and turnover play important roles in the maturation, metabolism and quality control of a large variety of RNAs thereby contributing to gene expression and cellular health.
Anderson, James T. +2 more
core +1 more source
RNA Helicases on the Move [PDF]
Biophysical Journal, 2014 We have investigated the mechanical properties of the RNA-helicase-motor proteins in single-molecule assays using Magnetic Tweezers. RNA helicases are fundamental molecular motors that remodel RNA structures, DNA/RNA hybrids and RNA-protein complexes that are essential in gene regulation.
Francesca Fiorini +6 more
openaire +2 more sources
Joint Efforts of Replicative Helicase and SSB Ensure Inherent Replicative Tolerance of G‐Quadruplex
Advanced ScienceG‐quadruplex (G4) is a four‐stranded noncanonical DNA structure that has long been recognized as a potential hindrance to DNA replication. However, how replisomes effectively deal with G4s to avoid replication failure is still obscure. Here, using single‐
Lijuan Guo +9 more
doaj +1 more source
Role of the Schizosaccharomyces pombe F-box DNA helicase in processing recombination intermediates. [PDF]
, 2005 In an effort to identify novel genes involved in recombination repair, we isolated fission yeast Schizosaccharomyces pombe mutants sensitive to methyl methanesulfonate (MMS) and a synthetic lethal with rad2.
Carr, Antony M +6 more
core +2 more sources
Regulation of translocation polarity by helicase domain 1 in SF2B helicases [PDF]
The EMBO Journal, 2011 Structurally similar superfamily I (SF1) and II (SF2) helicases translocate on single-stranded DNA (ssDNA) with defined polarity either in the 5'-3' or in the 3'-5' direction. Both 5'-3' and 3'-5' translocating helicases contain the same motor core comprising two RecA-like folds.
Maria Spies, Robert A. Pugh, Colin Wu
openaire +3 more sources