Results 91 to 100 of about 194,742 (384)

Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate

Nature Communications, 2016
The Cdc45-MCM-GINS (CMG) helicase unwinds DNA during the elongation step of eukaryotic genome duplication and this process depends on the MCM ATPase function.
F. Abid Ali, L. Renault, J. Gannon, Hailey L. Gahlon, A. Kotecha, J. C. Zhou, D. Rueda, Alessandro Costa   +7 more
semanticscholar   +1 more source

A Sisyphean helicase

The Journal of Cell Biology, 2005
Some helicases continually bang their heads against the wall, if a new report from Sua Myong, Taekjip Ha (University of Illinois, Urbana-Champaign, IL), and colleagues is any indication. The Rep helicase, the group finds, repeatedly motors along a track of DNA, hits an obstacle, and returns to square one.
openaire   +3 more sources

Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA [PDF]

, 2013
In eukaryotes, the Cdt1-bound replicative helicase core MCM2-7 is loaded onto DNA by the ORC-Cdc6 ATPase to form a prereplicative complex (pre-RC) with an MCM2-7 double hexamer encircling DNA.
A Costa, A Fernández-Cid, Alberto Riera, Alejandra Fernández-Cid, AS Brewster, AY Lyubimov, B Stillman, BA Kelch, BI Khayrutdinov, Bruce Stillman, C Evrin, C Evrin, C Liu, C Santocanale, C Speck, C Speck, Cecile Evrin, Christian Speck, D Remus, D Remus, D Suck, E Arias-Palomo, EF Pettersen, EL Dueber, G Tang, GC Lander, GD Bowman, GD Pintilie, H Li, H Li, Hironori Kawakami, Huilin Li, I Ilves, IN Chesnokov, J Frigola, J Liu, J Sun, JC Randell, Jingchuan Sun, JL Bowers, L Zou, M Gaudier, M O'Donnell, MG Clarey, MG Clarey, ML Baker, ML Bochman, ML Bochman, ML Bochman, PW Lau, R Henderson, RC Heller, RD Klemm, RJ Fletcher, S Chen, S Donovan, S Onesti, S Waga, SE Moyer, SL Forsburg, SP Bell, SP Bell, Stefan A Samel, T Miyata, T Pape, Y Ishimi, Y Kawasaki, YH Kang, Z Chen   +68 more
core   +1 more source

Topoisomerase I Inhibition in ETV4‐overexpressed Non‐Small Cell Lung Cancer Promotes Replication and Transcription Mediated R‐Loop Accumulation and DNA Damage

Advanced Science, EarlyView.
The oncogenic ETS factor ETV4 exerts a pleiotropic control over DNA replication both in a transcription‐dependent and ‐independent fashion in NSCLC cells. High‐ETV4 expression leads to R‐loop formation and DNA damage in response to TOP1 inhibition.
Jiaxi Zhang, Yan Wang, Shanhu Cao, Shelly M. Xie, Bei Liu, Yimeng Li, Yuqi Hou, Xue Meng, Mingzhu Ruan, Di Bu, Jia Kang, Ruxin Li, Lei Lou, Juan Wang, Lingxiao Xing   +14 more
wiley   +1 more source

The archaeal ATPase PINA interacts with the helicase Hjm via its carboxyl terminal KH domain remodeling and processing replication fork and Holliday junction. [PDF]

, 2018
PINA is a novel ATPase and DNA helicase highly conserved in Archaea, the third domain of life. The PINA from Sulfolobus islandicus (SisPINA) forms a hexameric ring in crystal and solution.
Ahmad, Sohail, DuPrez, Kevin, Fan, Li, Gu, Lichuan, Han, Xiaoyun, Ni, Jinfeng, Shen, Yulong, Xu, Cheng, Yuan, Zenglin, Zhai, Binyuan   +9 more
core   +1 more source

USP10 Inhibits Ferroptosis via Deubiquinating POLR2A in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study identifies USP10 as a novel deubiquitinase that antagonizes ferroptosis in head and neck squamous cell carcinoma (HNSCC). Mechanistically, USP10 directly stabilizes POLR2A protein through post‐translational deubiquitination, enabling POLR2A‐mediated transcriptional activation of SLC7A11, a key ferroptosis inhibitor.
Diekuo Zhang, Xueying Wang, Shanhong Lu, Yan Gao, Gangcai Zhu, Guo Li, Zongnan Yu, Junwei Hou, Helei Yan, Wenhui Yuan, Xin Zhang, Mien‐Chie Hung, Zhifeng Liu, Yong Liu   +13 more
wiley   +1 more source

UPF1-like helicase grip on nucleic acids dictates processivity

Nature Communications, 2018
Helicases are molecular engines which translocate along nucleic acids (NA) to unwind double-strands or remodel NA–protein complexes. While they have an essential role in genome structure and expression, the rules dictating their processivity remain ...
Joanne Kanaan, Saurabh Raj, Laurence Decourty, Cosmin Saveanu, V. Croquette, H. Le Hir   +5 more
semanticscholar   +1 more source

RNA Helicases on the Move [PDF]

Biophysical Journal, 2014
We have investigated the mechanical properties of the RNA-helicase-motor proteins in single-molecule assays using Magnetic Tweezers. RNA helicases are fundamental molecular motors that remodel RNA structures, DNA/RNA hybrids and RNA-protein complexes that are essential in gene regulation.
Francesca Fiorini, Hervé Le Hir, Josette Banroques, Raj Saurabh, Kyle Tanner, Vincent Croquette, Debjiani Bagchi   +6 more
openaire   +2 more sources

Roles of the Bloom's syndrome helicase in the maintenance of genome stability [PDF]

, 2005
The RecQ family of DNA helicases is highly conserved in evolution from bacteria to humans. Of the five known human RecQ family members, three (BLM, WRN and RECQ4, which cause Bloom's syndrome, Werner's syndrome and Rothmund-Thomson syndrome respectively)
Bachrati, Csanad, Chan, K. L., Cheok, C. F., Hickson, I. D., Ralf, C., Wu, L.   +5 more
core   +1 more source

Epigenetic Activation of CCDC183‐AS1 Promotes Osteoclastogenesis and Prostate Cancer Bone Metastasis Through the FUBP1/LIGHT Axis

Advanced Science, EarlyView.
CCDC183‐AS1 overexpression enhanced the ability of PCa cells to spread to the bone by inducing osteoclastogenesis. Mechanistically, CCDC183‐AS1 interacted with FUBP1 and enhanced its stability, which promoted the transcription of TNFSF14 (LIGHT). Copy number gain‐induced KDM5C epigenetically upregulated CCDC183‐AS1 expression by recruiting TET1 to the ...
Chuandong Lang, Xiangyu Mu, Kun Chen, Xinwen Wang, Yuluo Rong, Jia Wang, Zongcheng Yang, Chi Yin, Yuhu Dai, Jun Xiao, Wenzhi Zhang   +10 more
wiley   +1 more source