Results 1 to 10 of about 342,007 (314)

RNA helicase A mediates association of CBP with RNA polymerase II. [PDF]

Cell, 1997
The coactivator CBP has been proposed to stimulate the expression of certain signal-dependent genes via its association with RNA polymerase II complexes. Here we show that complex formation between CBP and RNA polymerase II requires RNA helicase A (RHA), a nuclear DNA/RNA helicase that is related to the Drosophila male dosage compensation factor mle ...
T. Nakajima, C. Uchida, S. Anderson, Chee-gun Lee, J. Hurwitz, J. Parvin, M. Montminy   +6 more
semanticscholar   +5 more sources

RNA Helicase A Regulates the Replication of RNA Viruses [PDF]

Viruses, 2021
The RNA helicase A (RHA) is a member of DExH-box helicases and characterized by two double-stranded RNA binding domains at the N-terminus. RHA unwinds double-stranded RNA in vitro and is involved in RNA metabolisms in the cell. RHA is also hijacked by a variety of RNA viruses to facilitate virus replication. Herein, this review will provide an overview
Rui-Zhu Shi, Yuan-Qing Pan, Li Xing
openaire   +4 more sources

Repetitive RNA unwinding by RNA helicase A facilitates RNA annealing [PDF]

Nucleic Acids Research, 2014
Helicases contribute to diverse biological processes including replication, transcription and translation. Recent reports suggest that unwinding of some helicases display repetitive activity, yet the functional role of the repetitiveness requires further
H. Koh, L. Xing, L. Kleiman, Sua Myong
semanticscholar   +3 more sources

The Human RNA Helicase DDX21 Presents a Dimerization Interface Necessary for Helicase Activity [PDF]

iScience, 2020
Members of the DEAD-box helicase family are involved in all fundamental processes of RNA metabolism, and as such, their malfunction is associated with various diseases. Currently, whether and how oligomerization impacts their biochemical and biological functions is not well understood.
Maria J. Marcaida, Annamaria Kauzlaric, Alice Duperrex, Jenny Sülzle, Martin C. Moncrieffe, Damilola Adebajo, Suliana Manley, Didier Trono, Matteo Dal Peraro   +8 more
openaire   +4 more sources

Domain Structure of Human Nuclear DNA Helicase II (RNA Helicase A)* [PDF]

Journal of Biological Chemistry, 1997
Full-length human nuclear DNA helicase II (NDH II) was cloned and overexpressed in a baculovirus-derived expression system. Recombinant NDH II unwound both DNA and RNA.
Suisheng Zhang, F. Grosse
semanticscholar   +3 more sources

LGP2 plays a critical role in sensitizing mda-5 to activation by double-stranded RNA. [PDF]

PLoS ONE, 2013
The DExD/H box RNA helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation associated gene-5 (mda-5) sense viral RNA in the cytoplasm of infected cells and activate signal transduction pathways that trigger the production of type I ...
A Komuro, A Peisley, A Pichlmair, A Pichlmair, AM Bruns, D Bamming, DA Pippig, DE Levy, DW Leung, G Lennon, H Kato, H Kato, IC Berke, IC Berke, J Andrejeva, K Childs, K Childs, Karen L. Mossman, Kay S. Childs, KS Childs, L Didcock, L Strahle, M Binder, M Schlee, M Yoneyama, MD Johnston, MJ Killip, N Masson, P King, R Marais, R Randall, Richard E. Randall, S Goodbourn, S Rothenfusser, Stephen Goodbourn, T Satoh, T Venkataraman, V Hornung, X Li, Y Kumagai, YM Loo, YM Loo   +41 more
core   +14 more sources

RNA helicase A is essential for normal gastrulation. [PDF]

Proceedings of the National Academy of Sciences, 1998
RNA helicase A (RHA) is the human homologue of the Drosophila maleless protein, an essential factor for the development of male flies. Recently, it was shown that RHA cooperates with the cAMP-responsive element in mediating the cAMP-dependent transcriptional activation of a number of genes.
Chee-gun Lee, Vera Soares, Carol Newberger, Katia Manova, Elizabeth Lacy, Jerard Hurwitz   +5 more
semanticscholar   +3 more sources

The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis. [PDF]

Cell Stem Cell, 2019
Post-transcriptional mechanisms have the potential to influence complex changes in gene expression, yet their role in cell fate transitions remains largely unexplored.
Bruno Di Stefano, E. Luo, Chuck Haggerty, S. Aigner, J. Charlton, J. Brumbaugh, Fei Ji, Inés Rabano Jiménez, Katie J. Clowers, A. Huebner, Kendell Clement, Inna Lipchina, Marit A C de Kort, A. Anselmo, John L. Pulice, M. Gerli, H. Gu, S. Gygi, R. Sadreyev, A. Meissner, Gene W. Yeo, K. Hochedlinger   +21 more
semanticscholar   +4 more sources

Detection of dsRNA-binding domains in RNA helicase A and Drosophila maleless: implications for monomeric RNA helicases [PDF]

Nucleic Acids Research, 1994
Searches with dsRNA-binding domain profiles detected two copies of the domain in each of RNA helicase A, Drosophila maleless and C. elegans ORF T20G5-11 (of unknown function). RNA helicase A is unusual in being one of the few characterised DEAD/DExH helicases that are active as monomers.
T. Gibson, J. Thompson
semanticscholar   +3 more sources

RNA helicase: a novel activity associated with a protein encoded by a positive strand RNA virus.

Nucleic Acids Research, 1990
Most positive strand RNA viruses infecting plants and animals encode proteins containing the so-called nucleotide binding motif (NTBM) (1) in their amino acid sequences (2). As suggested from the high level of sequence similarity of these viral proteins with the recently described superfamilies of helicase-like proteins (3-5), the NTBM-containing ...
Sonia Laín, JoséL. Riechmann, Juan Antonio García   +2 more
semanticscholar   +4 more sources