Results 11 to 20 of about 342,007 (314)

Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A.

Cancer Research, 2006
Abstract RNA helicase A (RHA), a member of the DEXH box helicase family of proteins, is an integral component of protein complexes that regulate transcription and splicing. The EWS-FLI1 oncoprotein is expressed as a result of the chromosomal translocation t(11;22) that occurs in patients with the Ewing's sarcoma family of tumors (ESFT ...
J. Toretsky, V. Erkizan, A. Levenson, O. Abaan, J. Parvin, T. Cripe, A. Rice, Sean-Bong Lee, A. Uren   +8 more
semanticscholar   +3 more sources

DEAD-box RNA Helicase DDX3: Functional Properties and Development of DDX3 Inhibitors as Antiviral and Anticancer Drugs

Molecules, 2020
This short review is focused on enzymatic properties of human ATP-dependent RNA helicase DDX3 and the development of antiviral and anticancer drugs targeting cellular helicases.
M. Kukhanova, I. Karpenko, A. Ivanov
semanticscholar   +3 more sources

Inhibiting the RNA helicase DDX3X in Burkitt lymphoma induces oxydative stress and impedes tumor progression in xenografts. [PDF]

Front Cell Dev Biol
IntroductionBurkitt Lymphoma (BL), an aggressive B-cell lymphoma driven by MYC translocations, requires intensive chemotherapy treatments which deliver high effectiveness yet increase future risks of developing secondary malignancies.
Beauchemin H, Dalloul Z, Piskor EM, Calderon V, Chatr-Aryamontri A, Bertomeu T, Möröy T.   +6 more
europepmc   +2 more sources

RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination

Molecular Cell, 2018
Summary Class switch recombination (CSR) at the immunoglobulin heavy-chain (IgH) locus is associated with the formation of R-loop structures over switch (S) regions.
Cláudia Ribeiro de Almeida, Somdutta Dhir, A. Dhir, A. Moghaddam, Quentin Sattentau, A. Meinhart, N. Proudfoot   +6 more
semanticscholar   +3 more sources

Molecular insights into RNA and DNA helicase evolution from the determinants of specificity for a DEAD-box RNA helicase

eLife, 2014
How different helicase families with a conserved catalytic ‘helicase core’ evolved to function on varied RNA and DNA substrates by diverse mechanisms remains unclear. In this study, we used Mss116, a yeast DEAD-box protein that utilizes ATP to locally unwind dsRNA, to investigate helicase specificity and mechanism.
Anna L Mallam, David J Sidote, Alan M Lambowitz   +2 more
openaire   +4 more sources

DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner.

Nucleic Acids Research, 2004
Suisheng Zhang, B. Schlott, M. Görlach, F. Grosse   +3 more
semanticscholar   +3 more sources

A Cold Shock-Induced Cyanobacterial RNA Helicase [PDF]

Journal of Bacteriology, 1999
ABSTRACT The ability to modify RNA secondary structure is crucial for numerous cellular processes. We have characterized two RNA helicase genes, crhB and crhC , which are differentially expressed in the cyanobacterium Anabaena sp. strain PCC 7120.
Owttrim, George W., Magee, Wendy C., Yu, Esther, Chamot, Danuta   +3 more
openaire   +3 more sources

Genome-wide comparative in silico analysis of the RNA helicase gene family in Zea mays and Glycine max: a comparison with Arabidopsis and Oryza sativa. [PDF]

PLoS ONE, 2013
RNA helicases are enzymes that are thought to unwind double-stranded RNA molecules in an energy-dependent fashion through the hydrolysis of NTP. RNA helicases are associated with all processes involving RNA molecules, including nuclear transcription ...
Ruirui Xu, Shizhong Zhang, Jinguang Huang, Chengchao Zheng   +3 more
doaj   +1 more source

Dengue Virus NS4b N-Terminus Disordered Region Interacts with NS3 Helicase C-Terminal Subdomain to Enhance Helicase Activity

Viruses, 2022
Dengue virus replicates its single-stranded RNA genome in membrane-bound complexes formed on the endoplasmic reticulum, where viral non-structural proteins (NS) and RNA co-localize.
Satyamurthy Kundharapu, Tirumala Kumar Chowdary   +1 more
doaj   +1 more source

The m6A reader YTHDC1 and the RNA helicase DDX5 control the production of rhabdomyosarcoma-enriched circRNAs

Nature Communications, 2023
N6-Methyladenosine (m^6A) is well-known for controlling different processes of linear RNA metabolism. Conversely, its role in the biogenesis and function of circular RNAs (circRNAs) is still poorly understood.
Dario Dattilo, Gaia Di Timoteo, A. Setti, Andrea Giuliani, G. Peruzzi, Manuel Beltran Nebot, Alvaro Centrón-Broco, D. Mariani, Chiara Mozzetta, I. Bozzoni   +9 more
semanticscholar   +1 more source