Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability [PDF]
, 2018 R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may occur transiently during transcription, playing essential biological functions. However, persistent R loops may become pathological
Aguilera López, Andrés +2 more
core +1 more source
The RNA helicase A in malignant transformation
Oncotarget, 2016 The RNA helicase A (RHA) is involved in several steps of RNA metabolism, such as RNA processing, cellular transit of viral molecules, ribosome assembly, regulation of transcription and translation of specific mRNAs. RHA is a multifunctional protein whose roles depend on the specific interaction with different molecular partners, which have been ...
Fidaleo M., De Paola E., Paronetto M. P.
openaire +4 more sources
Coordinated function of cellular DEAD-box helicases in suppression of viral RNA recombination and maintenance of viral genome integrity. [PDF]
PLoS Pathogens, 2015 The intricate interactions between viruses and hosts include an evolutionary arms race and adaptation that is facilitated by the ability of RNA viruses to evolve rapidly due to high frequency mutations and genetic RNA recombination.
Chingkai Chuang +2 more
doaj +1 more source
Primase-polymerases are a functionally diverse superfamily of replication and repair enzymes [PDF]
, 2015 Until relatively recently, DNA primases were viewed simply as a class of proteins that synthesize short RNA primers requisite for the initiation of DNA replication.
Aidan J. Doherty +17 more
core +1 more source
RNA helicase A activity is inhibited by oncogenic transcription factor EWS-FLI1
Nucleic Acids Research, 2015 RNA helicases impact RNA structure and metabolism from transcription through translation, in part through protein interactions with transcription factors.
Hayriye V. Erkizan +12 more
semanticscholar +1 more source
The RNA helicase DDX5 is a reprogramming roadblock [PDF]
Stem Cell Investigation, 2017 The reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is a major challenge for medical applications such as regenerative medicine since iPSCs can be used to generate different types of functional differentiated cells. Up to now, strategies aiming at reprogramming somatic cells have been mainly conducted toward the targeting of ...
Cyril F, Bourgeois, Didier, Auboeuf
openaire +2 more sources
Structural basis of Zika virus helicase in recognizing its substrates
Protein & Cell, 2016 The recent explosive outbreak of Zika virus (ZIKV) infection has been reported in South and Central America and the Caribbean. Neonatal microcephaly associated with ZIKV infection has already caused a public health emergency of international concern.
Hongliang Tian +14 more
doaj +1 more source
Association of RNA Helicase A with Human Immunodeficiency Virus Type 1 Particles*
Journal of Biological Chemistry, 2006 RNA helicase A (RHA) belongs to the DEAH family of proteins that are capable of unwinding double-stranded RNA structure. In addition to its involvement in the metabolism of cellular RNA, RHA has been shown to stimulate RNA transcription from the long ...
B. B. Roy +6 more
semanticscholar +1 more source
Nature Medicine, 2009 Many sarcomas and leukemias carry nonrandom chromosomal translocations encoding tumor-specific mutant fusion transcription factors that are essential to their molecular pathogenesis. Ewing's sarcoma family tumors (ESFTs) contain a characteristic t(11;22)
Hayriye V. Erkizan +10 more
semanticscholar +1 more source
Caenorhabditis elegans RIG-I Homolog Mediates Antiviral RNA Interference Downstream of Dicer-Dependent Biogenesis of Viral Small Interfering RNAs. [PDF]
, 2017 Dicer enzymes process virus-specific double-stranded RNA (dsRNA) into small interfering RNAs (siRNAs) to initiate specific antiviral defense by related RNA interference (RNAi) pathways in plants, insects, nematodes, and mammals.
Gina Broitman-Maduro +10 more
core +3 more sources