Results 21 to 30 of about 342,007 (314)

Structural basis of the T4 bacteriophage primosome assembly and primer synthesis

Nature Communications, 2023
The T4 bacteriophage gp41 helicase and gp61 primase assemble into a primosome to couple DNA unwinding with RNA primer synthesis for DNA replication. How the primosome is assembled and how the primer length is defined are unclear.
Xiang Feng, Michelle M. Spiering, Ruda de Luna Almeida Santos, Stephen J. Benkovic, Huilin Li   +4 more
doaj   +1 more source

DbpA is a region‐specific RNA helicase [PDF]

Biopolymers, 2016
AbstractDbpA is a DEAD‐box RNA helicase implicated in RNA structural rearrangements in the peptidyl transferase center. DbpA contains an RNA binding domain, responsible for tight binding of DbpA to hairpin 92 of 23S ribosomal RNA, and a RecA‐like catalytic core responsible for double‐helix unwinding. It is not known if DbpA unwinds only the RNA helices
Moore, Anthony F.T., Gentry, Riley C., Koculi, Eda   +2 more
openaire   +3 more sources

Nuclear DNA Helicase II/RNA Helicase A Binds to Filamentous Actin [PDF]

Journal of Biological Chemistry, 2002
Nuclear DNA helicase II (NDH II), also designated RNA helicase A, is a multifunctional protein involved in transcription, RNA processing, and transport. Here we report that NDH II binds to F-actin. NDH II was partially purified from HeLa nuclear extracts by ion-exchange chromatography on Bio-Rex 70 and DEAE-Sepharose. Upon gel-filtration chromatography
Suisheng, Zhang, Katrin, Buder, Carmen, Burkhardt, Bernhard, Schlott, Matthias, Görlach, Frank, Grosse   +5 more
openaire   +2 more sources

HrpA, an RNA helicase involved in RNA processing, is required for mouse infectivity and tick transmission of the Lyme disease spirochete. [PDF]

PLoS Pathogens, 2013
The Lyme disease spirochete Borrelia burgdorferi must differentially express genes and proteins in order to survive in and transit between its tick vector and vertebrate reservoir. The putative DEAH-box RNA helicase, HrpA, has been recently identified as
Aydan Salman-Dilgimen, Pierre-Olivier Hardy, Justin D Radolf, Melissa J Caimano, George Chaconas   +4 more
doaj   +1 more source

RNA helicase domains of viral origin in proteins of insect retrotransposons: possible source for evolutionary advantages [PDF]

PeerJ, 2017
Recently, a novel phenomenon of horizontal gene transfer of helicase-encoding sequence from positive-stranded RNA viruses to LINE transposons in insect genomes was described.
Sergey Y. Morozov, Ekaterina A. Lazareva, Andrey G. Solovyev   +2 more
doaj   +2 more sources

P68 RNA helicase is a nucleocytoplasmic shuttling protein [PDF]

Cell Research, 2009
P68 RNA helicase is a prototypical DEAD box RNA helicase. The protein plays a very important role in early organ development and maturation. Consistent with the function of the protein in transcriptional regulation and pre-mRNA splicing, p68 was found to predominately localize in the cell nucleus.
Wang, Haizhen, Gao, Xueliang, Huang, Yun, Yang, Jenny, Liu, Zhi-Ren   +4 more
openaire   +2 more sources

Development of a database of RNA helicase inhibitors (VHIMDB) of pathogenic viruses and in silico screening for the potential drug molecules

The EuroBiotech Journal, 2022
The pathogenic RNA virus that infects human beings contains the RNA helicase enzyme, responsible for the replication of the viral genome. The enzyme is used as a suitable target against which the drug molecule acts.
Satpathy R, Acharya S
doaj   +1 more source

Role and therapeutic potential of DEAD-box RNA helicase family in colorectal cancer

Frontiers in Oncology, 2023
Colorectal cancer (CRC) is the third most commonly diagnosed and the second cancer-related death worldwide, leading to more than 0.9 million deaths every year. Unfortunately, this disease is changing rapidly to a younger age, and in a more advanced stage
Bichun Zheng, Xudong Chen, Qiaoyun Ling, Quan Cheng, Shaoshun Ye   +4 more
doaj   +1 more source

Identification of Five Putative Yeast RNA Helicase Genes [PDF]

, 1990
The RNA helicase gene family encodes a group of eight homologous proteins that share regions of sequence similarity. This group of evolutionarily conserved proteins presumably all utilize ATP (or some other nucleoside triphosphate) as an energy source ...
Abelson, John, Arenas, Jaime, Chang, Tien-Hsien   +2 more
core   +1 more source

Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export [PDF]

The EMBO Journal, 1998
The DBP5 gene encodes a putative RNA helicase of unknown function in the yeast Saccharomyces cerevisiae. It is shown here that Dbp5p is an ATP-dependent RNA helicase required for polyadenylated [poly(A)+] RNA export. Surprisingly, Dbp5p is present predominantly, if not exclusively, in the cytoplasm, and is highly enriched around the nuclear envelope ...
S S, Tseng, P L, Weaver, Y, Liu, M, Hitomi, A M, Tartakoff, T H, Chang   +5 more
openaire   +2 more sources