Results 121 to 130 of about 109,831 (197)

ATP is dispensable for E. coli DNA replication and eukaryotic helicase activity. [PDF]

Nat Commun
Spinks RR, Lakic A, Kelso C, Jergic S, Yurieva O, Xu ZQ, O'Donnell ME, Dixon NE, van Oijen AM, Lewis JS, Spenkelink LM.   +10 more
europepmc   +1 more source

Acute capillary blood DNA methylation responses to swimming exercise in high‐performance male and female swimmers

Experimental Physiology, EarlyView.
Abstract Epigenetic markers, particularly DNA methylation, are promising tools for monitoring athlete health and training due to their role in cellular regulation, exercise responsiveness and molecular stability. However, exercise‐induced epigenetic changes in peripheral blood in trained individuals remain unexplored.
C. D. Goldsmith, N. G. Lawler, D. B. Pyne, M. Kozlovskaia, K. McGibbon, L. J. G. Mitchell, A. D. Govus   +6 more
wiley   +1 more source

MCM8-9 helicase activity protects primordial germ cell development to prevent premature ovarian insufficiency. [PDF]

Proc Natl Acad Sci U S A
Jiao X, Li Z, Tang Z, Xu J, Lu LY, Liu Y.   +5 more
europepmc   +1 more source

Bloom Syndrome Presenting With Early‐Onset Myelodysplastic Syndrome and Triple Overlapping Vascular Neurocutaneous Phenotypes: A Case Report

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Bloom syndrome is a rare autosomal recessive chromosomal instability disorder characterized by growth deficiency and early‐onset malignancies, and its coexistence with multiple vascular neurocutaneous syndromes is exceptionally uncommon. We report an 8‐year‐old girl who presented with severe growth failure and persistent pancytopenia.
Elham Shahgholi, Nahid Khosroshahi, Sara Sadeghi   +2 more
wiley   +1 more source

DDX21 Promotes Breast Cancer Growth and Metastasis via Stimulating RNAPII Elongation During Hypoxia

MedComm, Volume 7, Issue 7, July 2026.
DDX21 triggers CDK9 release from the 7SK RNP complex. DDX21‐CDK9 binding to HIFs drives transcriptional reprogramming during hypoxia. DDX21 enhances breast cancer progression and metastasis. Elevated DDX21 expression correlates with poor prognosis in breast cancer patients.
Guangqiang Li, Mingxia Deng, Leqing Zhu, Zhiwei Lei, Rong Guo, Xiong Liu, Renwang Chen, Xichun Xia, Qiong Wen, Yuanyuan Duan, Yan Chen, Zhinan Yin   +11 more
wiley   +1 more source

Orchestrating innate immunity through RNA editing and helicase activity: ADAR1, dsRNA sensors, and tumor immune evasion. [PDF]

Front Cell Dev Biol
Minakuchi M, Salvino JM, Villanueva J.
europepmc   +1 more source

RNA Modifications in Tumor Microenvironment: A New Dimension for Cancer Treatment

MedComm, Volume 7, Issue 7, July 2026.
Tumor initiation and progression depend on a supportive and highly heterogeneous tumor microenvironment (TME). RNA modifications regulate signaling pathways and cytokine networks that shape TME dynamics, facilitating interactions between cancer cells and noncancerous stromal cells, and ultimately promoting immune evasion and tumor progression ...
Qiwen Li, Yating Sun, Shuibin Lin, Quan Yuan   +3 more
wiley   +1 more source

Processing of reversed replication forks is required for the resolution of replication-transcription conflicts. [PDF]

Nucleic Acids Res
Carvajal-Garcia J, Merrikh H.
europepmc   +1 more source

Fecal Proteomics Suggest Potential Biomarkers for Non‐Alcoholic Fatty Liver Disease and Steatohepatitis

PROTEOMICS – Clinical Applications, Volume 20, Issue 4, July 2026.
ABSTRACT Background and aims Non‐alcoholic Fatty Liver Disease (NAFLD) affects about a quarter of the world's population. Liver biopsy remains the gold standard for diagnosing the progressive form of NAFLD called Non‐alcoholic Steatohepatitis (NASH) but it is invasive, prone to sampling errors and observer variability, and impractical for widespread ...
Anna Negroni, Luisa Pieroni, Noemi Fiaschini, Francesca Palone, Mariateresa Mancuso, Roberta Vitali   +5 more
wiley   +1 more source

A conundrum resolved: regulation and activation of UvrD-family DNA helicases/translocases. [PDF]

Trends Biochem Sci
Lohman TM, Mersch KN, Chadda A, Nguyen B, Galburt EA.   +4 more
europepmc   +1 more source