Results 171 to 180 of about 194,742 (384)

Natural Products Targeting Protein Disulfide Isomerases: New Frontiers for Diabetes, Cancer, and Coagulation

Food Frontiers, EarlyView.
PDIA4 is significantly upregulated in response to nutrient overload in pancreatic β‐cells, resulting in aberrant ROS production, β‐cell failure, and diabetes. PDIA4 facilitates cancer development by inhibiting caspase‐mediatedcell death in cancer and promoting VEGF‐mediated protumoral immunity andangiogenesis in the tumor microenvironment, highlighting
Yi‐San Lee, Catherine Ortega, Tien‐Fen Kuo, Greta Yang, Wen‐Chin Yang   +4 more
wiley   +1 more source

Protein Degradation Pathways Regulate the Functions of Helicases in the DNA Damage Response and Maintenance of Genomic Stability

Biomolecules, 2015
Degradation of helicases or helicase-like proteins, often mediated by ubiquitin-proteasomal pathways, plays important regulatory roles in cellular mechanisms that respond to DNA damage or replication stress.
Joshua A. Sommers, Avvaru N. Suhasini, Robert M. Brosh   +2 more
doaj   +1 more source

A fluorescence-based helicase assay: application to the screening of G-quadruplex ligands

Nucleic Acids Research, 2015
Helicases, enzymes that unwind DNA or RNA structure, are present in the cell nucleus and in the mitochondrion. Although the majority of the helicases unwind DNA or RNA duplexes, some of these proteins are known to resolve unusual structures such as G ...
O. Mendoza, N. M. Gueddouda, J. Boulé, A. Bourdoncle, J. Mergny   +4 more
semanticscholar   +1 more source

Transcriptional Regulation of Microglial Metabolic and Activation States by P2RY12

Glia, EarlyView.
Transcriptionally, P2RY12‐deficient microglia show heightened metabolic activity, iron handling, and oxidative stress at baseline. Upon LPS challenge, impaired glutathione antioxidant responses suggest increased vulnerability to ferroptosis. ABSTRACT Microglia are the resident immune cells of the CNS.
Aida Oryza Lopez‐Ortiz, Madison Doceti, JaQuinta Thomas, Abigayle Duffy, Morgan Coburn, Akhabue K. Okojie, Audrey Lee, Elizabeth Aidita Sou, Alban Gaultier, Ukpong B. Eyo   +9 more
wiley   +1 more source

Switch on the engine: how the eukaryotic replicative helicase MCM2–7 becomes activated

Chromosoma, 2015
A crucial step during eukaryotic initiation of DNA replication is the correct loading and activation of the replicative DNA helicase, which ensures that each replication origin fires only once.
Silvia Tognetti, A. Riera, C. Speck
semanticscholar   +1 more source

Unveiling Origin Pitfalls in Metagenomic Surveillance for Emerging Infectious Diseases: Parvoviruses as a Model

iMetaMed, EarlyView.
A diverse reagent‐associated virome, including parvoviruses, misleads zoonotic surveillance. By leveraging large language models (ChatGPT‐4o), we construct a virus discovery data framework (PVDDC) and ParvoDB to access and correct host misattributions, thereby enhancing the accuracy of metagenomic surveillance for emerging zoonotic diseases.
Peng Zhao, Jie Dong, Hong Liu, Data Research and Curation Team, Ying Xue, Ting Zhang, Hongtao Sui, Yongfeng Hu, Jiang Du, Haoxiang Su, Qi Jin, Fan Yang   +11 more
wiley   +1 more source

Bavachalcone targets transferrin receptor and sensitizes gemcitabine to affect bladder cancer progression

iMeta, EarlyView.
Transferrin (Tf) binds extracellular Fe3+ and interacts with transferrin receptor (TFRC) on the cell membrane, leading to endocytosis. Iron is reduced by STEAP3, transported by DMT1 into the cytoplasm, then enters mitochondria to support Fe–S cluster formation, mitochondrial respiration, and ATP production.
Zihao Zhang, Chenyue Yuan, Qintao Ge, Dalong Cao, Wangrui Liu, Meng Xu, Mengfei Wang, Tao Feng, Yue Wang, Shengfeng Zheng, Zhongyuan Wang, Wei zhang, Xi Tian, Wei Huang, Ziqi Chen, Chao Tu, Hailiang Zhang, Guohai Shi, Jialin Meng, Yijun Shen, Ziliang Wang, Dingwei Ye   +21 more
wiley   +1 more source

Recent advances in isothermal amplification techniques coupled with clustered regularly interspaced short palindromic repeat/Cas systems

Interdisciplinary Medicine, EarlyView.
Abstract Isothermal amplification (IA) techniques have emerged as promising alternatives to polymerase chain reaction (PCR), enabling rapid and efficient nucleic acid amplification at constant temperatures. Meanwhile, clustered regularly interspaced short palindromic repeat (CRISPR)/Cas‐based technology has revolutionized molecular diagnostics by ...
Miao Liu, Yajun Hou, Yuhang Cheng, Ziyun Li, Jiawei Zeng, Li Li, Jinyong Luo, Bo Shen   +7 more
wiley   +1 more source

Role of the Srs2-Rad51 Interaction Domain in Crossover Control in Saccharomyces cerevisiae. [PDF]

, 2019
Saccharomyces cerevisiae Srs2, in addition to its well-documented antirecombination activity, has been proposed to play a role in promoting synthesis-dependent strand annealing (SDSA).
Ede, Christopher, Gore, Steven, Guo, Xiaoge, Heyer, Wolf-Dietrich, Jenkins, Shirin S, Jinks-Robertson, Sue, Kowalczykowski, Stephen C, Liu, Jie, Veaute, Xavier   +8 more
core  

Integration of CRISPR‐Cas9 screens and multi‐omics profiling reveals chromodomain helicase DNA binding protein 7‐angiopoietin‐1 as a novel multidrug resistance axis in acute myeloid leukemia

Interdisciplinary Medicine, EarlyView.
Abstract Acute myeloid leukemia (AML) is a devastating hematological malignancy and one of the most prevalent forms of leukemia in adults. Despite recent advancements and approval of novel targeted therapies, drug resistance remains a formidable clinical challenge.
Dandan Yang, Tingting Zhang, Yang Yang, Dong Zhang, Zhiwei Zhou, Ning Wang, Jinting Fan, Chenghua Xu, Youyang Fang, Lichun Kang, Mingming Niu, Chunliang Li, Long Shen, Hong Wang   +13 more
wiley   +1 more source