Results 191 to 200 of about 194,742 (384)

From Fluctuations to Function: Unveiling the Role of Stochasticity in Life‐Like Systems

open access: yesChemSystemsChem, EarlyView.
In this short review, we put forward the idea that randomly fluctuating, or stochastic, molecular events can and do play a role in the emergence of complex biological phenomena at longer length scales. There is a growing body of evidence of this occurring in natural systems, and we survey the computational and experimental attempts of researchers to ...
Aleksa Lakic, Alexander F. Mason
wiley   +1 more source

CRISPR/Cas9‐edited tumor‐associated immune cells in cancer immunotherapy

open access: yesVIEW, EarlyView.
Abstract Immuno‐oncology represents an emerging field that has significantly transformed tumor therapeutics, with immune cells serving as the cellular foundations of cancer immunotherapy. Due to its high efficiency and sensitivity, CRISPR/Cas9 genome editing is a highly promising technique for precise and rapid gene modification.
Yuhui Ma   +6 more
wiley   +1 more source

Corrigendum: The Cellular Functions and Molecular Mechanisms of G-Quadruplex Unwinding Helicases in Humans

open access: yesFrontiers in Molecular Biosciences, 2022
Yang Liu   +11 more
doaj   +1 more source

Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36

open access: yesNature, 2018
Michael C. Chen   +6 more
semanticscholar   +1 more source

Discovery of natural product derivative triptolidiol as a direct NLRP3 inhibitor by reducing K63‐specific ubiquitination

open access: yesBritish Journal of Pharmacology, EarlyView.
▪ Background and Purpose NLRP3 is up‐regulated in inflammatory and autoimmune diseases. The development of NLRP3 inhibitors is challenged by the identification of compounds with distinct mechanisms of action avoiding side effects and toxicity. Triptolide is a natural product with multiple anti‐inflammatory activities, but a narrow therapeutic window ...
Mo‐Yu Ding   +5 more
wiley   +1 more source

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