Results 251 to 260 of about 168,391 (336)

Identification and application of herbicide‐resistant 4‐hydroxyphenylpyruvate dioxygenase (HPPD) alleles via directed evolution

open access: yes
Plant Biotechnology Journal, EarlyView.
Bingbing Zhao   +11 more
wiley   +1 more source

Comprehensive genetic and epigenetic characterization of Lynch‐like syndrome patients

open access: yesInternational Journal of Cancer, Volume 157, Issue 4, Page 788-799, 15 August 2025.
What's new? Lynch‐like syndrome is associated with development of colorectal cancer (CRC) with microsatellite instability and loss of expression of certain mismatch repair (MMR) genes, similar to Lynch syndrome, but unlike Lynch syndrome, the genetic cause of Lynch‐like syndrome (LLS) remains unknown.
Francesca Pirini   +18 more
wiley   +1 more source

Gut Microbiome Pilot Study of Patients With CHARGE Syndrome and Sibling Controls

open access: yesAmerican Journal of Medical Genetics Part A, Volume 197, Issue 8, August 2025.
ABSTRACT Difficulties with feeding and digestion are common in individuals with CHARGE syndrome. Animal models with CHD7 gene variants demonstrate abnormal gut innovation and dysmotility. Our pilot study evaluated whether individuals with CHARGE syndrome have differences in their gut microbiome compared to unaffected siblings.
Emily R. Chedrawe   +5 more
wiley   +1 more source

Improvement of the Anticancer Efficacy of PD‐1/PD‐L1 Blockade: Advances in Molecular Mechanisms and Therapeutic Strategies

open access: yesMedComm, Volume 6, Issue 8, August 2025.
Mechanisms of alleviating resistance to PD‐1/PD‐L1 blockade by IFN‐α and IFN‐β. In these mechanisms, the “yin‐yang balance” is disrupted, thus preventing T cells from attacking cancer cells. Restoring this balance may improve the efficacy of anti‐PD‐1/PD‐L1 therapy and reinvigorate T cells and other immune cells to target and destroy cancer cells ...
Peng Gao   +7 more
wiley   +1 more source

Unwinding process of DNA/RNA quadruplexes by proteins under label-free nanopore monitoring. [PDF]

open access: yesNucleic Acids Res
Ren M   +10 more
europepmc   +1 more source

A coarse‐grained model for disordered proteins under crowded conditions

open access: yesProtein Science, Volume 34, Issue 8, August 2025.
Abstract Macromolecular crowding may strongly affect the dynamics and function of proteins, with intrinsically disordered proteins being particularly sensitive to their crowded environment. To understand the influences of crowding on chain compaction and phase separation (PS) behavior of disordered proteins, both experiments with synthetic crowders ...
Arriën Symon Rauh   +2 more
wiley   +1 more source

Division of labor within polymerase theta in repair of CRISPR-induced DNA breaks in <i>Arabidopsis thaliana</i>. [PDF]

open access: yesPNAS Nexus
Kamoen L   +8 more
europepmc   +1 more source

The quest for the best target genes for RNAi‐mediated pest control

open access: yesInsect Molecular Biology, Volume 34, Issue 4, Page 505-517, August 2025.
A major challenge for RNAi mediated pest control is the identification of the most effective RNAi target genes from the pool of ~37% of all genes that are essential. Effective RNAi target genes are predominantly highly conserved genes serving basic cellular functions such as protein degradation.
Doga Cedden, Gregor Bucher
wiley   +1 more source

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