Results 251 to 260 of about 168,391 (336)
Comprehensive genetic and epigenetic characterization of Lynch‐like syndrome patients
What's new? Lynch‐like syndrome is associated with development of colorectal cancer (CRC) with microsatellite instability and loss of expression of certain mismatch repair (MMR) genes, similar to Lynch syndrome, but unlike Lynch syndrome, the genetic cause of Lynch‐like syndrome (LLS) remains unknown.
Francesca Pirini+18 more
wiley +1 more source
Gut Microbiome Pilot Study of Patients With CHARGE Syndrome and Sibling Controls
ABSTRACT Difficulties with feeding and digestion are common in individuals with CHARGE syndrome. Animal models with CHD7 gene variants demonstrate abnormal gut innovation and dysmotility. Our pilot study evaluated whether individuals with CHARGE syndrome have differences in their gut microbiome compared to unaffected siblings.
Emily R. Chedrawe+5 more
wiley +1 more source
Disruption of a topoisomerase-DNA cleavage complex by a DNA helicase.
M. T. Howard+3 more
openalex +2 more sources
The bacterial transcription terminator, Rho, functions as an RNA:DNA hybrid (RDH) helicase in vivo. [PDF]
Bhosale A, Sen R.
europepmc +1 more source
Mechanisms of alleviating resistance to PD‐1/PD‐L1 blockade by IFN‐α and IFN‐β. In these mechanisms, the “yin‐yang balance” is disrupted, thus preventing T cells from attacking cancer cells. Restoring this balance may improve the efficacy of anti‐PD‐1/PD‐L1 therapy and reinvigorate T cells and other immune cells to target and destroy cancer cells ...
Peng Gao+7 more
wiley +1 more source
Unwinding process of DNA/RNA quadruplexes by proteins under label-free nanopore monitoring. [PDF]
Ren M+10 more
europepmc +1 more source
A coarse‐grained model for disordered proteins under crowded conditions
Abstract Macromolecular crowding may strongly affect the dynamics and function of proteins, with intrinsically disordered proteins being particularly sensitive to their crowded environment. To understand the influences of crowding on chain compaction and phase separation (PS) behavior of disordered proteins, both experiments with synthetic crowders ...
Arriën Symon Rauh+2 more
wiley +1 more source
Division of labor within polymerase theta in repair of CRISPR-induced DNA breaks in <i>Arabidopsis thaliana</i>. [PDF]
Kamoen L+8 more
europepmc +1 more source
The quest for the best target genes for RNAi‐mediated pest control
A major challenge for RNAi mediated pest control is the identification of the most effective RNAi target genes from the pool of ~37% of all genes that are essential. Effective RNAi target genes are predominantly highly conserved genes serving basic cellular functions such as protein degradation.
Doga Cedden, Gregor Bucher
wiley +1 more source