Results 281 to 290 of about 168,391 (336)

New Pyridobenothiazolone Derivatives Display Nanomolar Pan‐Serotype Anti‐Dengue Virus Activity

ChemMedChem, Volume 20, Issue 13, July 1, 2025.
A ligand‐based strategy is employed, starting from hit compound 2, to develop the C‐2 modified pyridobenzothiazolone 19 as a pan‐serotype nanomolar DENV‐1‐4 inhibitor. Investigations of the mechanism reveal the peculiar ability to abolish the infectivity of virions in a second infection.
Tommaso Felicetti, Chin Piaw Gwee, Kitti Wing Ki Chan, Giacomo Pepe, Ciro Milite, Pietro Campiglia, Satoru Watanabe, Muhammad Danial Bin Mohd Mazlan, Stefano Sabatini, Serena Massari, Oriana Tabarrini, Gianluca Sbardella, Subhash G. Vasudevan, Giuseppe Manfroni   +13 more
wiley   +1 more source

Whole Exome Sequencing Identifies a Novel Frameshift Mutation of the WRN Gene in a Werner Syndrome Family and Functional Analysis. [PDF]

Mol Genet Genomic Med
Xiong H, Gao H, Wan J, Xiao J, Luo X, Dong X, Wu Y, Liu T.   +7 more
europepmc   +1 more source

PDK4 and nutrient responses explain muscle specific manifestation in mitochondrial disease

Clinical and Translational Medicine, Volume 15, Issue 7, July 2025.
Mitochondrial disease triggers opposite responses in different muscles. Mitochondrial integrated stress response (ISRmt) and aerobic glycolysis characterize large muscles. Eye muscles show no ISRmt but activate PDK4—inhibitor of glucose oxidation—thereby upregulating beta‐oxidation, which is non‐optimal in mitochondrial disease and can explain eye ...
Swagat Pradhan, Takayuki Mito, Nahid A Khan, Sofiia Olander, Aleksandra Zhaivoron, Thomas G McWilliams, Anu Suomalainen   +6 more
wiley   +1 more source

The Serine Protease and RNA-Stimulated Nucleoside Triphosphatase and RNA Helicase Functional Domains of Dengue Virus Type 2 NS3 Converge within a Region of 20 Amino Acids

, 1999
Haitao Li, Stephen Clum, Shihyun You, K.E. Ebner, R. Padmanabhan   +4 more
openalex   +1 more source

SARS-CoV-2 point mutations are over-represented in terminal loops of RNA stem-loop structures that can be resolved by Nsp13 helicase in a unique manner with respect to nucleotide dependence. [PDF]

Nucleic Acids Res
Dumm AJ, Zheng AY, Butler TJ, Kulikowicz T, George JC, Bombard PT, Sommers JA, Ding J, Brosh RM.   +8 more
europepmc   +1 more source

Efficacy of Haloxyfop‐R‐Methyl on Allium cepa: Cyto‐Genotoxic and In Silico Docking Studies on the Mechanism of Action

Microscopy Research and Technique, Volume 88, Issue 7, Page 2048-2062, July 2025.
ABSTRACT Haloxyfop‐R‐methyl (HRM) is extensively employed to control annual and perennial grass weeds. This study aimed to investigate the cyto‐genotoxic effects of HRM at concentrations of 1.19, 2.38, and 4.76 mg/L over various time intervals (24, 48, 72, and 96 h) on Allium cepa root.
Recep Liman, Emine Kılıç, Erman Salih İstifli, Yudum Yeltekin Uğur, İbrahim Hakkı Ciğerci   +4 more
wiley   +1 more source

A conserved phosphorylation mechanism for regulating the interaction between the CMG replicative helicase and its forked DNA substrate. [PDF]

J Biol Chem
Koit S, Tamberg N, Reinapae A, Peil L, Kristjuhan A, Ilves I.   +5 more
europepmc   +1 more source

Ten‐Eleven Translocation Family Proteins: Structure, Biological Functions, Diseases, and Targeted Therapy

MedComm, Volume 6, Issue 7, July 2025.
TET family proteins play a critical role in DNA demethylation, and their mutations and dysregulation contribute to the onset of multiple diseases. With a deeper understanding of the molecular mechanisms of TET involvement in disease, drug therapy targeting TET proteins shows great potential, which provides insights into new therapeutic strategies ...
Junzhi Liang, Xinni Na, Lingbo Meng, Lixia He, Ting Shu, Yuanyuan Fang, Bowen Zhang, Zhongyu Zhao, Cuishan Guo, Tingting Li, Zhijing Na, Da Li, Xue Xiao   +12 more
wiley   +1 more source

Dbl2 interacts with helicases and an endonuclease to maintain the integrity of repetitive regions. [PDF]

Sci Rep
Bakosova A, Cipak L, Mayerova N, Krol K, Benko Z, Pitelova A, Kolesar P, Piatrova D, Smondrkova M, Maresova A, Molnarova L, Cipakova I, Altmannova V, Bellova J, Barath P, Prevorovsky M, Palecek J, Krejci L, Gregan J, Skoneczna A, Polakova SB.   +20 more
europepmc   +1 more source

Small Nucleolar RNAs: Biological Functions and Diseases

MedComm, Volume 6, Issue 7, July 2025.
The majority of snoRNAs are derived from the intron region of genes, besides to intronic snoRNAs, some snoRNAs are transcribed as independent genes, often by Pol II or III, these snoRNAs are called intergenic snoRNAs. All of these play a role in the occurrence and progression of various diseases through multiple functions.
Yi Wang, Min Fu, Zaiyong Zheng, Jianguo Feng, Chunxiang Zhang   +4 more
wiley   +1 more source