Results 291 to 300 of about 168,391 (336)

An RNA helicase coordinates with iron signal regulators to alleviate chilling stress in Arabidopsis. [PDF]

Nat Commun
Xing Y, Li Y, Gui X, Zhang X, Hu Q, Zhao Q, Qiao Y, Xu N, Liu J.   +8 more
europepmc   +1 more source

Advancing Design Strategy of PROTACs for Cancer Therapy

MedComm, Volume 6, Issue 7, July 2025.
A comprehensive update on the PROTAC design, and highlighting the role of artificial intelligence in the PROTAC design for cancer therapy. ABSTRACT Proteolysis targeting chimeras (PROTACs) have emerged as a groundbreaking class of anticancer therapeutics.
Hang Luo, Yuan Tian, Razack Abdullah, Baoting Zhang, Yuan Ma, Ge Zhang   +5 more
wiley   +1 more source

Structural Chemistry of Helicase Inhibition. [PDF]

J Med Chem
Selvaratnam L, Willson TM, Schapira M.
europepmc   +1 more source

Transforming Growth Factor‐β Pathway: Biological Functions and Therapeutic Targets

MedComm, Volume 6, Issue 7, July 2025.
Natural compounds modulate the TGF‐β pathway, which acts as both a tumor suppressor and promoter during cancer progression. Agents such as ginsenosides, halofuginone, and EGCG influence cell proliferation, apoptosis, and angiogenesis. These bioactive molecules may complement standard therapies, highlighting the need for advanced formulations ...
Reham Hassan Mekky, Mohammed E. Abo‐El Fetoh, Safaa A. Faheem, Abdullah F. Radwan, Mariam H. Fawzy, Aya M. Mustafa, Mohamed A. Said, Daniela Calina, Javad Sharifi‐Rad, William C. Cho   +9 more
wiley   +1 more source

Structural basis for Polθ-helicase DNA binding and microhomology-mediated end-joining. [PDF]

Nat Commun
Ito F, Li Z, Minakhin L, Khant HA, Pomerantz RT, Chen XS.   +5 more
europepmc   +1 more source

Establishment of a Protocol for CE‐MS Based Peptidome Analysis of Human Saliva

PROTEOMICS, Volume 25, Issue 13, July 2025.
ABSTRACT Proteins and peptides indicate physiological or pathological states and are investigated to identify markers to scrutinize health and disease surveillance. Saliva contains many proteins and peptides that could serve as biomarkers, offering a potential noninvasive approach for disease detection.
Carl‐Johan Törnhage, Björn Peters, Agnieszka Latosinska, Ioanna K. Mina, Marika Mokou, Harald Mischak, Justyna Siwy   +6 more
wiley   +1 more source

DDX3X/MAVS alleviates doxorubicin‑induced cardiotoxicity by regulating stress granules. [PDF]

Mol Med Rep
Zhao K, Wang S, Feng D, Wang D, Yang G, Lang F.   +5 more
europepmc   +1 more source

Synthesis and Chemical Characterization of Chloroquine, Hydroxychloroquine, Zinc, and Cinnamic Acid Organocomplexes: Potential Drug Candidates for SARS‐CoV‐2 Treatment and Microbial Control

ChemistrySelect, Volume 10, Issue 27, July 18, 2025.
Zn‐quinolines were synthesized with high yields of 78% and 85%. The study focuses on drug repositioning to improve properties and reduce toxicity for COVID‐19 treatment. New Zn‐based compounds demonstrated antiviral and antimicrobial activities with low toxicity.
Carla Peron, Paulo Roberto dos Santos, João Pedro de Oliveira Mezzomo, Fernando Joel Scariot, Ariel Maia, Laura Calle Gonzalez, Deise do Nascimento de Freitas, Ana Paula Longaray Delamare, Pablo Machado, Ana Paula Duarte de Souza, Sidnei Moura   +10 more
wiley   +1 more source

Formalin‐fixed paraffin‐embedded (FFPE) samples help to investigate transcriptomic responses in wildlife disease

Molecular Ecology Resources, Volume 25, Issue 5, July 2025.
Abstract Infectious diseases impact numerous organisms. Knowledge of host‐pathogen interactions and host responses to infection is crucial for conservation and management. Obtaining this knowledge quickly is made increasingly possible by a variety of genomic approaches, yet, for many species the bottleneck to understanding this, remains access to ...
Allison K. Miller, Cara L. Brosnahan, Anjali Pande, Cindy F. Baker, Jemma L. Geoghegan, Jane Kitson, Neil J. Gemmell, Edwina J. Dowle   +7 more
wiley   +1 more source

The DNA damage tolerance factor Rad5 and telomere replication. [PDF]

Curr Genet
Mattarocci S.
europepmc   +1 more source