Results 51 to 60 of about 164,924 (263)

Helicobacter pylori‐Induced Persistent IGF2BP1 Activation Promotes Ferroptosis Resistance in Gastric Tumorigenesis

Advanced Science, EarlyView.
Helicobacter pylori infection induces sustained upregulation of the RNA‐binding protein IGF2BP1 in gastric epithelial cells, establishing a persistent epitranscriptomic program. IGF2BP1 stabilizes SLC7A11 mRNA in an m6A‐dependent manner to suppress ferroptosis and promote epithelial survival under oxidative stress. Pharmacological inhibition of IGF2BP1
Jing Ning, Xin Guan, Xinyu Hao, Jing Zhang, Deyao Li, Ying Xiong, Wenlin Zhang, Xiurui Han, Yanfei Lang, Meiling Zhou, Mengjie Yang, Zhi Huang, Tinghui Qu, Ming Zu, Qiao Meng, Weiwei Fu, Fengmin Lu, Jing Zhang, Xiangmei Chen, Tong Liu, Shigang Ding   +20 more
wiley   +1 more source

The Effects of Two Novel Copper-Based Formulations on Helicobacter pylori

Antibiotics, 2013
We investigated the effects of two novel copper-based inorganic formulations for their activity against 60 isolates of Helicobacter pylori (Hp). The two copper-based formulations were tested against three NCTC Helicobacter pylori isolates and 57 clinical
John Holton, Dino Vaira, Giovanna Lo Re, Cristina Zaccaro, Ilaria M. Saracino   +4 more
doaj   +1 more source

Helicobacter pylori-induced histone modification, associated gene expression in gastric epithelial cells, and its implication in pathogenesis. [PDF]

, 2010
Histone modifications are critical in regulating gene expression, cell cycle, cell proliferation, and development. Relatively few studies have investigated whether Helicobacter pylori, the major cause of human gastric diseases, affects histone ...
Haas, Rainer, Rainer Haas, Grant, Patrick, Kaparakis-Liaskos, Maria, Hass, Rainer, Sheila E Crowe, Patrick A. Grant, Crowe, Sheila E., Crowe Sheila E., Liechti, George, Ferrero, Richard L., Richard L. Ferrero, D. Scott Merrell, Kaparakis-Liaskos Maria, Merrell, D. Scott, Wolfgang Fischer, Fischer, Wolfgang, Liechti George, Ferrero Richard L., Ding, Song-Ze, Goldberg Joanna B., Song-Ze Ding, Ding Song-Ze, George Liechti, Patrick A Grant, Crowe, Sheila, Goldberg, Joanna, Fischer Wolfgang, Joanna B Goldberg, D Scott Merrell, Hatakeyama, Masanori, Ferrero, Richard, Merrell D. Scott, Haas Rainer, Joanna B. Goldberg, Goldberg, Joanna B., Richard L Ferrero, Sheila E. Crowe, Masanori Hatakeyama, Grant Patrick A., Hatakeyama Masanori, Grant, Patrick A., Liaskos, Maria, Maria Kaparakis-Liaskos   +43 more
core   +1 more source

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

The epidemiology of Helicobacter pylori resistance in a university affiliated hospital: a comparison between two time periods—a cross-sectional design

European Journal of Medical Research, 2023
Purpose During the last few decades, the increased use of various types of antibiotics in the general population caused a significant change in regional Helicobacter pylori (H. pylori) antibiotic resistance. Our aim is to study the changes in H.
Haim Shmuely, Yekaterina Shvartsman, Rita Berdinstein, Jacob Yahav, Ehud Melzer   +4 more
doaj   +1 more source

ROS/pH‐Responsive Phenylboronic Acid–Chitosan Nanoparticles Improve Silymarin‐Mediated Hepatoprotection After Hepatectomy With Gut‐Liver Axis‐Associated Responses

Advanced Science, EarlyView.
Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong, Chaochao Luo, Zezheng Liu, Xinyan Zhang, Daixu Jia, Yang Sun, Zhaonan Zhang, Haoran Shi, Jianfang Wang, Hua Zhang   +9 more
wiley   +1 more source

The Effect of Fermented Homemade-Style Yogurt in Helicobacter Pylori Eradication

Boğaziçi Tıp Dergisi, 2019
INTRODUCTION[|]Helicobacter pylori (Hp) infection is common worldwide and may be involved in the pathogenesis of gastritis, peptic ulcer, and gastric malignancy.
Şengül Aydın Yoldemir, Gulden Yuruyen
doaj   +1 more source

Eradication of gastric Helicobacter Pylori : are we getting there? [PDF]

, 1995
In 1984 a curved bacillus living in the stomach of patients with gastritis and peptic ulceration was discovered and isolated. This organism named as Helicobacter Pylori (HP), has been shown to play a major role in the causation of duodenal ulcers ...
Pullicino, Edgar
core  

The HP0256 gene product is involved in motility and cell envelope architecture of Helicobacter pylori [PDF]

, 2010
Background Helicobacter pylori is the causative agent for gastritis, and peptic and duodenal ulcers. The bacterium displays 5-6 polar sheathed flagella that are essential for colonisation and persistence in the gastric mucosa.
Caly, Delphine L., O\u27Toole, Paul W., Penn Charles W, Stanley A Moore, Douillard, FP, Douillard, François P., Ryan, KA, Caly Delphine L, Hinds, Jason, Francois P Douillard, Charles W Penn, Moore, SA, Paul W O'Toole, Moore Stanley A, Lane, Michael C., Hinds Jason, Kieran A Ryan, Ryan Kieran A, Lane Michael C, Michael C Lane, Delphine C Caly, O'Toole Paul W, O'Toole, PW, Ryan, Kieran A., Penn, Charles, Caly, DL, Hinds, J, Penn, CW, Penn, Charles W., Jason Hinds, Lane, MC, Moore, Stanley A., Douillard François P, O'Toole, Paul W.   +33 more
core   +1 more source

Chromosomal Abnormalities, Drug Sensitivity and Resistance in Hematological Malignancies: A Comprehensive Overview by the Francophone Group of Hematological Cytogenetics (GFCH)

American Journal of Hematology, EarlyView.
ABSTRACT Chromosomal abnormalities have a major clinical impact on hematological malignancies, particularly with regard to treatment strategies. To preserve and consolidate fundamental knowledge in this rapidly evolving field, the Francophone Group of Hematological Cytogenetics (Groupe Francophone de Cytogénétique Hématologique, GFCH) conducted a ...
Florence Nguyen‐Khac, Audrey Bidet, Elise Chapiro, Nathalie Douet‐Guilbert, Jean‐Baptiste Gaillard, Nada Assaf, Nathalie Auger, Hend Chaker, Jasmine Chauzeix, Inge Govaerts, Hippolyte Guérineau, Christine Lefebvre, Pauline Roynard, Hélène Guermouche, Lucienne Michaux, Marie‐Bérengère Troadec, Lauren Véronèse   +16 more
wiley   +1 more source