Results 61 to 70 of about 234,919 (306)

Lymphoma caused by intestinal microbiota. [PDF]

, 2014
The intestinal microbiota and gut immune system must constantly communicate to maintain a balance between tolerance and activation: on the one hand, our immune system should protect us from pathogenic microbes and on the other hand, most of the millions ...
Schiestl, Robert H, Yamamoto, Mitsuko L
core   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Recent acquisition of Helicobacter pylori by Baka Pygmies [PDF]

, 2013
Both anatomically modern humans and the gastric pathogen Helicobacter pylori originated in Africa, and both species have been associated for at least 100,000 years. Seven geographically distinct H.
AB Migliano, Armand Nkwescheu, Ayas Maady, B Linz, B Pakendorf, Bodo Linz, C Batini, C Ehret, CM Schlebusch, CY Tay, D Falush, D Falush, D Schoenbrun, Daniel Eibach, Daniel Falush, DD Palmer, DM Behar, DM Magalhaes Queiroz, DY Graham, E Patin, G Brusotti, G Hellenthal, G Jobb, G Morelli, Gil McVean, JC Assob, JG Kusters, Jose Siri, JZ Li, KA Jolley, L Excoffier, L Naduvilezhath, L Quintana-Murci, LA Zhivotovsky, M Achtman, M Guisset, M Jakobsson, M Kawai, Mark Achtman, MC Campbell, MF Rupnow, MF Rupnow, MF Rupnow, MJ Hamilton, MK Gonder, NA Drake, NA Rosenberg, NS Becker, P Librado, RE Pounder, RN Ndip, RN Ndip, RR Hudson, RR Hudson, RW Frenck Jr, S Breurec, S Latifi-Navid, S Schwarz, SA Tishkoff, Sandra Nell, SC Schuster, Sebastian Suerbaum, T Wirth, TH Farag, V Kuete, V Montano, Valeria Montano, W Delport, Wael F. Elamin, X Didelot, Y Chen, Y Moodley, Y Moodley, Yoshan Moodley   +73 more
core   +3 more sources

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Misidentifying Helicobacters: the Helicobacter cinaedi Example [PDF]

Journal of Clinical Microbiology, 2000
ABSTRACT Whole-cell protein electrophoresis and biochemical examination by means of a panel of 64 tests were used to identify 14 putative helicobacters to the species level. The results were confirmed by means of DNA-DNA hybridization experiments and were used to discuss misidentification of helicobacters based on 16S rRNA gene ...
P, Vandamme, C S, Harrington, K, Jalava, S L, On   +3 more
openaire   +2 more sources

Multi‐Scale Interface Engineering of MXenes for Multifunctional Sensory Systems

Advanced Functional Materials, EarlyView.
MXenes, as two‐dimensional transition metal carbides and nitrides, demonstrate remarkable capabilities for multifunctional sensing applications. This review systematically examines multi‐scale interface engineering approaches that enhance sensing performance, enable diverse detection functionalities, and improve system‐level compatibility in MXene ...
Jiaying Liao, Sin‐Yi Pang, Jianhua Hao
wiley   +1 more source

Long-term memory in epithelia: transient IFNγ exposure drives stable repression of TFF1 in gastric epithelial cells via epigenetic changes

Frontiers in Immunology
IntroductionInterferon-gamma (IFNγ) is a pro-inflammatory cytokine that is transiently produced and typically activates short-lived JAK–STAT1 signaling, yet it can also induce long-term transcriptional changes.
Antonia Voli, Daniela Eletto, Fatima Maria Mentucci, Chiara Centrella, Chiara Centrella, Martina Pannetta, Francesco Boccellato, Alfonso Finizio, Silvana Morello, Caterina Giraulo, Amalia Porta, Alessandra Tosco   +11 more
doaj   +1 more source

The SlyD metallochaperone targets iron-sulfur biogenesis pathways and the TCA cycle

mBio, 2023
Control of protein folding is a conserved function in all domains of life. The ubiquitous peptidyl-prolyl cis-trans isomerases (PPIases) catalyze the cis/trans-isomerization of peptidyl-prolyl bonds, often a rate-limiting step for protein folding ...
Milica Denic, Evelyne Turlin, Deborah B. Zamble, Jean-Michel Betton, Daniel Vinella, Hilde De Reuse   +5 more
doaj   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source