Results 91 to 100 of about 236,492 (306)

Chimeric RNA-binding protein-based killing switch targeting hepatocellular carcinoma cells

Molecular Therapy: Nucleic Acids, 2021
Cancer cell-specific killing switches are synthetic circuits developed as an intelligent weapon to specifically eliminate malignant cells. RNA-delivered synthetic circuits provide safer means to control oncolytic functions, in which proteolysis ...
Jiong Yang, Shigang Ding
doaj  

Lipopolysaccharide Structural Differences between Western and Asian Helicobacter pylori Strains

Toxins, 2018
Recent structural analysis of the lipopolysaccharide (LPS) isolated from Helicobacter pylori G27 wild-type and O-antigen ligase mutant resulted in the redefinition of the core-oligosaccharide and O-antigen domains.
Hong Li, Hong Tang, Aleksandra W. Debowski, Keith A. Stubbs, Barry J. Marshall, Mohammed Benghezal   +5 more
doaj   +1 more source

Prevalence of Helicobacter pylori infection in adult patients with dyspeptic symptoms in Abdi Waluyo Hospital Jakarta from January 2017 to December 2019

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2021
Background: Helicobacter pylori infection is a global public health problem and may be present in more than half of the world’s population  Prevalence in developing country higher compared to developed country.
Maureen Irawati, Felix Aloysius Budimutiar, Guntur Darmawan, Deborah Theresia Budimutiar, Marcellus Simadibrata   +4 more
doaj   +1 more source

Dissecting the Spatial and Single‐Cell Transcriptomic Architecture of Cancer Stem Cell Niche Driving Tumor Progression in Gastric Cancer

Advanced Science, EarlyView.
A single‐cell and spatial transcriptional atlas reveals the architecture of human gastric cancer stem cell (CSC) niche and the developmental trajectory of CSCs. These CSCs interact with immunosuppressive immune cells thereby constructing immune‐suppressive niche, and inflammatory cancer‐associated fibroblast (iCAFs) to enhance stemness through ...
Guangyu Zhang, Xin Zhang, Wenting Pan, Xizhao Chen, Lingfei Wan, Chunjie Liu, Yuting Yong, Yue Zhao, Shuli Sang, Lihua Zhang, Sheng Yao, Yushu Guo, Mingmei Wang, Xinhui Wang, Guangdun Peng, Xinlong Yan, Yanchun Wang, Min Zhang   +17 more
wiley   +1 more source

Efficient Degradation and Expression Prioritization with Small RNAs [PDF]

physical biology 4, 164-171 (2007), 2006
We build a simple model for feedback systems involving small RNA (sRNA) molecules based on the iron metabolism system in the bacterium E. coli, and compare it with the corresponding system in H. pylori which uses purely transcriptional regulation. This reveals several unique features of sRNA based regulation that could be exploited by cells.
arxiv   +1 more source

Prevalence of Helicobacter pylori IgG and stool antigen detection from dyspeptic patients in Jos, Nigeria [PDF]

, 2018
Helicobacter pylori is a helical shaped gram negative microaerophilic bacterium, that can inhabit various areas of the stomach. The study was carried out to determine the prevalence of Helicobacter pylori infection among dyspeptic patients attending ...
Ani, A., Oladele, O.V., Ombugadu, D.O., Omisope, O., Onuoha, S.C.   +4 more
core   +2 more sources

Antagonist Targeting the Species‐Specific Fatty Acid Dehydrogenase/Isomerase FabX for Anti‐H. pylori Infection

Advanced Science, EarlyView.
This study demonstrates that the atypical dehydrogenase/isomerase FabX in Type‐II fatty acid biosynthesis pathway is essential for H. pylori infection by retaining unsaturated fatty acid synthesis and producing superoxide (ROS). A small molecule FBX‐1991 that specifically targets FabX to inhibit H.
Lin Zhang, Xiaoxue Ruan, Xudong Hang, Ding Heng, Chang Cai, Liping Zeng, Guoxin Zhang, Lu Zhou, Hongkai Bi, Liang Zhang   +9 more
wiley   +1 more source

Effect of Helicobacter Pylori Eradication on Extent of Duodenal Gastric Metaplasia and Grade of Gastritis [PDF]

, 2002
The extent of the regression of duodenal gastric metaplasia (DGM) after the eradication of Helicobacter pylori infection is controversial. Therefore, we decided to assess the degree of DGM before, sex weeks and one year after H. pylori eradication.
A. Bilić, D. Jandrić, D. Strinić, J. Bago, M. Tomić, P. Bago, Ž. Belošić Halle   +6 more
core   +1 more source

The local immune response of mice after Helicobacter suis infection: strain differences and distinction with Helicobacter pylori [PDF]

, 2012
Helicobacter (H.) suis colonizes the stomach of pigs and is the most prevalent gastric non-H. pylori Helicobacter species in humans. Limited information is available on host immune responses after infection with this agent and it is unknown if variation ...
Ducatelle, Richard, Flahou, Bram, Haesebrouck, Freddy, Pasmans, Frank, Rychlik, Ivan, Smet, Annemieke, Van Deun, Kim, Volf, Jiri   +7 more
core   +3 more sources

Hydrogel‐Transformable Probiotic Powder for Targeted Eradication of Helicobacter pylori with Enhanced Gastric Mucosal Repair and Microbiota Preservation

Advanced Science, EarlyView.
A multifunctional, edible, and hydrogel‐transformable probiotic powder is developed based on the “bacteria‐mediated bacterial eradication” strategy. By leveraging the targeted binding capability of L. reuteri to H. pylori, this approach achieves an integrated therapeutic effect, including bactericidality, anti‐inflammation, gastric mucosal repair, and ...
Yongkang Lai, Hanchun Shen, Shige Wang, Yongliang Ouyang, Xinyuan Zhang, Bin Hu, Xiaoyi Zhang, Guisheng Li, Lizhi Xu, Jiulong Zhao   +9 more
wiley   +1 more source