Results 101 to 110 of about 156,187 (258)

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Single-cell and pseudobulk analyses reveal hidden mitochondrial expression imbalance in gastric cancer

Frontiers in Genetics
BackgroundMitochondrial function is essential for biology, particularly in cancer. However, cell-type-specific expression patterns of conserved mitochondrial genes in gastric cancer (GC) remain unclear.
Le Chang, Jingwen Hou, Yingying Li, Simeng Liu, Pengya Feng, Ya Li, Ya Li, Chunjing Qiu, Pengyuan Zheng, Xia Xue, Yang Mi, Yang Mi   +11 more
doaj   +1 more source

Two distinct aetiologies of cardia cancer, evidence from premorbid serological markers of gastric atrophy and Helicobacter pylori status [PDF]

, 2007
Background: Non-cardia gastric adenocarcinoma is positively associated with Helicobacter pylori infection and atrophic gastritis. The role of H pylori infection and atrophic gastritis in cardia cancer is unclear.
Derakhshan, M.H., Jellum, E., McColl, K.E.L., Melby, K.K., Fyfe, V., Aase, S., Hansen, S., Vollset, S.E.   +7 more
core   +1 more source

Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged as an essential technique for elucidating this molecular complexity ...
Holden T. Rogers, Zachery R. Gregorich, Megan S. Gant, Zhan Gao, Julia Chamot‐Rooke, Ying Ge   +5 more
wiley   +1 more source

TDP-43-driven alternative splicing of UQCRC2 modulates mitochondrial bioenergetics

Biology Direct
TAR DNA-binding protein 43 (TDP-43) is a nuclear RNA-binding protein. It has emerged as a key regulator of RNA processing, such as alternative splicing events, which are essential for cellular homeostasis.
Xia Xue, Jingwen Hou, Zhiqi Zhang, Zeting Yang, Le Chang, Zengguang Yang, Simeng Liu, Huang Huang, Lu Mei, Yang Mi, Pengyuan Zheng, Xiangdong Sun   +11 more
doaj   +1 more source

Helicobacter pylori type IV secretion apparatus exploits beta1 integrin in a novel RGD-independent manner. [PDF]

, 2009
Translocation of the Helicobacter pylori (Hp) cytotoxin-associated gene A (CagA) effector protein via the cag-Type IV Secretion System (T4SS) into host cells is a major risk factor for severe gastric diseases, including gastric cancer.
Haas, Rainer, Rainer Haas, Kapp, Ulrike, Jung, Kirsten, Kirsten Jung, Rohde, Manfred, Claudia Ertl, Retta, S. Francesco, S. Francesco Retta, Terradot Laurent, Ertl, Claudia, Luisa F. Jiménez-soto, Luisa F Jiménez-Soto, Fischer Rainer Haas, Retta S. Francesco, Pirch Torsten, Weiss, Evelyn, Xaver Sewald, Jiménez-Soto Luisa F., Wolfgang Fischer, Ertl Claudia, Evelyn Weiss, Jiménez-Soto, Luisa F., Fischer, Wolfgang, Weiss Evelyn, Manfred Rohde, Kutter, Stefan, Kutter Stefan, Pirch, Torsten, Terradot, Laurent, Sewald, Xaver, Fischer Wolfgang, Torsten Pirch, Laurent Terradot, S Francesco Retta, Haas Rainer, Rohde Manfred, Kapp Ulrike, Ulrike Kapp, Retta, Saverio Francesco, Stefan Kutter, Jung Kirsten, Sewald Xaver   +42 more
core   +2 more sources

Apigenin Protects Hypertensive Intracerebral Hemorrhage by Regulating Trx1 Through Binding to PRDX2

Phytotherapy Research, EarlyView.
ABSTRACT Intracerebral hemorrhage (ICH) remains the most severe stroke subtype with high mortality and disability rates. Although apigenin has shown cerebroprotective potential in preclinical studies, its mechanism of action, particularly in hypertensive ICH, remains poorly understood.
Hao‐chen Xu, Ming Liu, Ying‐ying Sun, Jie‐Dan Ping, Qing‐hua Cui, Jing‐zhou Chen, Hao Li   +6 more
wiley   +1 more source

Integrative nomogram model based on anoikis-related genes enhances prognostic evaluation in colorectal cancer

Heliyon
Background: Revealing the role of anoikis resistance plays in CRC is significant for CRC diagnosis and treatment. This study integrated the CRC anoikis-related key genes (CRC-AKGs) and established a novel model for improving the efficiency and accuracy ...
Yuexiao Zhang, Xia Xue, Fazhan Li, Bo Zhang, Pengyuan Zheng, Yang Mi   +5 more
doaj   +1 more source

Helicobacter pylori and the management of gastro-oesophageal reflux disease [PDF]

, 2005
This thesis is centred on the current controversy and possible links between H. pylori and GORD and whether the infection should be eradicated in those requiring long PPIs.
Raghunath, Anathakrishnapuram Srinivasan
core  

Apo10 and TKTL1 as novel liquid biopsy biomarkers for early detection of gastrointestinal malignancies

VIEW, EarlyView.
(A) Overview of the study population and schematic illustration showing tumor‐derived apoptotic and metabolic biomarkers, Apo10 and TKTL1, being phagocytosed by circulating monocytes and subsequently detected in peripheral blood. (B) Illustration of the epitope detection in monocytes (EDIM) strategy, using a flow‐cytometric gating approach based on ...
Zhiying Mao, Qiyu Huang, Juan Xiao, Ziyu Liu, Xinyan Zou, Yuying Liu, Lizhi Liu, Musheng Zeng, Chuanbo Xie   +8 more
wiley   +1 more source