Results 81 to 90 of about 89,054 (257)

Knowledge gaps in tubular gut tumours: a critical appraisal of the 6th edition of the World Health Organization classification of tumours

open access: yesThe Journal of Pathology, EarlyView.
Abstract Gastrointestinal cancer is a global health problem. In the new 6th edition of the World Health Organization Classification of Tumours (WCT) of the Digestive System, updated evidence and guidance is provided for the aetiology, pathogenesis, diagnosis, classification, grading, staging and prognosis of these tumours.
Iris D Nagtegaal   +5 more
wiley   +1 more source

Proteomic Changes in Cancer Cell Lines as a Result of Bacterial Infection

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Bacterial infections have been implicated in shaping the tumor microenvironment (TME), but their effects on cancer cell proteomes remain unexplored. In this study, we analyzed proteomic changes in melanoma (A375) and ovarian cancer (OVCAR3) cell line models following infection with Staphylococcus aureus strain USA300 or Salmonella enterica ...
Bo Ren   +7 more
wiley   +1 more source

RNA‐binding protein RBMS1: A new target for cancer diagnosis and treatment

open access: yesPrecision Medical Sciences, EarlyView.
This schematic illustrates the diverse regulatory roles of RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) across multiple human cancers. In breast cancer, RBMS1 stabilizes B4GALT1 mRNA to promote PD‐L1 glycosylation, modulating tumor immune escape and immunotherapy efficacy.
Xingda Run   +7 more
wiley   +1 more source

Apo10 and TKTL1 as novel liquid biopsy biomarkers for early detection of gastrointestinal malignancies

open access: yesVIEW, EarlyView.
(A) Overview of the study population and schematic illustration showing tumor‐derived apoptotic and metabolic biomarkers, Apo10 and TKTL1, being phagocytosed by circulating monocytes and subsequently detected in peripheral blood. (B) Illustration of the epitope detection in monocytes (EDIM) strategy, using a flow‐cytometric gating approach based on ...
Zhiying Mao   +8 more
wiley   +1 more source

Systemic Impact of Helicobacter pylori: A Cross‐Sectional Study

open access: yesJGH Open
Background and Aim Helicobacter pylori is an oncobacteria that infects about half of the world's population and has a well‐established role in the etiology of gastric diseases.
Amanda Ferreira Paes Landim Ramos   +7 more
doaj   +1 more source

The International Guideline for the Definition, Classification, Diagnosis and Management of Urticaria

open access: yesAllergy, EarlyView.
ABSTRACT This update and revision of the international guideline for urticaria was developed in accordance with the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is an initiative of the Global Allergy and Asthma Excellence Network (GA2LEN) and its Urticaria and ...
T. Zuberbier   +221 more
wiley   +1 more source

Changing Aetiology of Perforated Peptic Ulcers: Rising Impact of Non‐Steroidal‐Anti‐Inflammatories in Western Australia

open access: yesANZ Journal of Surgery, EarlyView.
ABSTRACT Background Peptic ulcer disease (PUD) continues to be a health issue, mainly due to Helicobacter pylori (H. pylori) infection and non‐steroidal anti‐inflammatory drugs (NSAIDs). Despite better treatment of H. pylori and use of proton pump inhibitors, the rate of reduction in PUD complications is slowing down.
Vidya Willis   +3 more
wiley   +1 more source

Increased circulating regulatory T cells and decreased follicular T helper cells are associated with colorectal carcinogenesis

open access: yesFrontiers in Immunology
ObjectiveColorectal cancer (CRC) is the third most prevalent cancer worldwide and is associated with high morbidity and mortality rates. Colorectal carcinogenesis occurs via the conventional adenoma-to-carcinoma and serrated pathways.
Qiao Meng   +10 more
doaj   +1 more source

P‐CAB vs. PPI for Upper Gastrointestinal Bleeding Prevention in Patients With Atherothrombotic Disease on Antithrombotic Therapy: A CDM Cohort Study

open access: yesAlimentary Pharmacology &Therapeutics, EarlyView.
In patients with atherothrombotic disease on antithrombotic therapy, P‐CABs demonstrated a significantly superior protective effect against clinically significant upper GI haemorrhage compared to PPIs (aHR 0.22; p = 0.016). This real‐world study highlights P‐CABs as a more potent gastroprotective strategy for high‐risk populations requiring intensive ...
Min Joo Yoon   +6 more
wiley   +1 more source

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