Results 81 to 90 of about 156,187 (258)

Engineering Bacteria for Medicine: Delivery, Diagnosis, and Therapy

iMetaMed, EarlyView.
ABSTRACT With rapid advances in synthetic biology and genetic engineering, genetically engineered bacteria (GEB) have emerged as a promising platform for biological therapy, addressing key limitations of conventional drug delivery systems and demonstrating significant clinical potential.
Shiyu Xia, Guiling Fu, Xiaoyue Ding, Wen Yang, Ruijie Bai, Yawei Cai, Jing xuan Zhang, Yanxia Wei, Conghui Han, Yi‐Zhou Gao, Ying Li, Zuobin Zhu   +11 more
wiley   +1 more source

Gut microbiota and its therapeutic implications in tumor microenvironment interactions

Frontiers in Microbiology
The development of cancer is not just the growth and proliferation of a single transformed cell, but its tumor microenvironment (TME) also coevolves with it, which is primarily involved in tumor initiation, development, metastasis, and therapeutic ...
Pengya Feng, Pengya Feng, Pengya Feng, Xia Xue, Xia Xue, Ihtisham Bukhari, Ihtisham Bukhari, Chunjing Qiu, Chunjing Qiu, Yingying Li, Yingying Li, Pengyuan Zheng, Pengyuan Zheng, Yang Mi, Yang Mi   +14 more
doaj   +1 more source

Differential Effect of Helicobacter pylori Eradication on Time-Trends in Brady/Hypokinesia and Rigidity in Idiopathic Parkinsonism [PDF]

, 2010
Background: We examine the effect of eradicating Helicobacter in idiopathic parkinsonism (IP). Marked deterioration, where eradication-therapy failed, prompted an interim report in the first 20 probands to reach de-blinding.
Bjarnason, IT, Lawson, Andrew J., Dobbs, RJ, Dobbs, R. John, Lucy Harbin, Ibrahim, Mohammad A. A.; id_orcid, Peterson, Dale W., Ibrahim, MA, J. Malcolm Plant, Smee, Cori, Daniel Leckstroem, Plant, JM, Charlett, A, Harbin, Lucy, Lawson, AJ, Bowthorpe, James, Ingvar T. Bjarnason, Mohammad A. A. Ibrahim, Price, AB, André Charlett, Clive Weller, Smee, C, Dobbs, Sylvia M., James Bowthorpe, Dale W. Peterson, Letley, Darren, Leckstroem, Daniel, Charlett, Andre, Weller, C, Andrew J. Lawson, Dobbs, SM, R. John Dobbs, Harbin, L, Letley, D, Price, Ashley B., Bjarnason, Ingvar T., Peterson, DW, Norman L. Oxlade, Weller, Clive, Bowthorpe, J, Ashley B. Price, Oxlade, NL, Oxlade, Norman L., Sylvia M. Dobbs, Plant, J. Malcolm, Darren Letley, Leckstroem, D, Cori Smee   +47 more
core   +1 more source

Blood Biomarkers of Helicobacter pylori‐Infected Chronic Gastritis in Active Versus Stable Phases: A Clinical Indicator Analysis Combined With Proteomic and Metabolomic Investigations

iMetaMed, EarlyView.
Combining clinical data with serum proteomics and metabolomics, the HGB–CAPZB–acetic acid model was developed as a potential diagnostic index to distinguish the active and stable stages of Helicobacter pylori‐infected chronic gastritis, and the related mechanism was explored through multi‐omics.
Tiantong Jiang, Zhen Ma, Yang Li, Shaoli Wang, Yanjiao Zhang, Lei Song, Xianyu Li, Zhen Liu   +7 more
wiley   +1 more source

A novel sulfonamide derivative suppresses gastrointestinal cancer progression by targeting Axin2 and β-catenin

Scientific Reports
Gastrointestinal cancer is a major global health risk with rising incidence and limited effective therapeutic options. Despite advancements in diagnostics and therapies, the aggressive nature of these malignancies make novel therapeutic strategies ...
Xiaojie Li, Huijuan Wen, Le Chang, Xia Xue, Huayuan Xi, Ruoyu Hu, Mengke Rong, Pengyuan Zheng, Simeng Liu   +8 more
doaj   +1 more source

Inhibitors of Helicobacter pylori protease HtrA found by "virtual ligand" screening combat bacterial invasion of epithelia [PDF]

, 2011
Background: The human pathogen Helicobacter pylori (H. pylori) is a main cause for gastric inflammation and cancer. Increasing bacterial resistance against antibiotics demands for innovative strategies for therapeutic intervention.
Löwer, Martin, Schneider, Gisbert, Petra Schneider, Hoy Benjamin, Löwer Martin, Martin Löwer, Tim Geppert, Geppert, Tim, Silja Wessler, Wessler Silja, Schneider, Petra, Geppert Tim, Gisbert Schneider, Benjamin Hoy, Hoy, Benjamin, Weßler, Silja, Schneider Petra, Schneider, Gisbert (Prof. Dr.), Schneider Gisbert   +18 more
core   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Tofacitinib Regulates β‐Catenin Nuclear Translocation to Inhibit FLS Migration and Alleviate Clinical Symptoms of RA

iNew Medicine, EarlyView.
ABSTRACT Objective Tofacitinib is a Janus kinase (JAK) inhibitor approved for the treatment of moderate‐to‐severe rheumatoid arthritis (RA). However, its synovium‐related molecular mechanisms, particularly its regulatory effect on fibroblast‐like synoviocyte (FLS) migration, remain incompletely understood.
Shuqi Fang, Tianjing Zhang, Ling Hu, Ruijin Liu, Leyi Jia, Menglin Bai, Jiale Dong, Yuchen Zhao, Han Wang, Lei Zhang, Tao Li, Youcai Deng, Xianzheng Zhang, Lingling Zhang   +13 more
wiley   +1 more source

HELICOBACTER PYLORI INFECTION IN CHILDREN

Majalah Kedokteran Andalas, 2011
AbstrakFaktor risiko infeksi Helicobacter pylori adalah tinggal di negara berkembang, kondisi sosial ekonomi yang rendah, jumlah anggota keluarga yang banyak, etnik dan genetik.
Yusri Dianne Jurnalis, Yorva Sayoet, Sari Dewi   +2 more
doaj   +1 more source

The Serum Levels of Endothelium Nitric Oxide Synthase in Positive Cases for Helicobacter pylori Stool Antigen [PDF]

Background & Objectives: Endothelium nitric oxide synthase (eNOS) is a type of enzyme which produces an endogenous factor called nitric oxide (NO). NO plays important role in progress of euplastic diseases.
اتحاد, غلامحسین, امانی, مجتبی, پهلوان, یاسمین, افشار قهرمانی, فیروزه   +3 more
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