Results 131 to 140 of about 6,329 (210)

DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy

MedComm, Volume 7, Issue 9, September 2026.
This review synthesizes the expanding biology of PAMPs and DAMPs, from their molecular sources and sensing mechanisms to regulatory networks that govern inflammation and homeostasis. Spanning from classical immune activation to trained immunity and interorgan communication, we highlight the interplay between PAMPs and DAMPs and their context‐dependent ...
Xuanxuan Yu, Yuqin Jin, Baochao Li, Jie Deng, Yiwen Zhou, Jinglun Zhang, Huang Li   +6 more
wiley   +1 more source

Adult Blow Flies Host Diverse Carrion‐Associated Microbiomes

New Zealand Journal of Zoology, Volume 53, Issue 3, September 2026.
Blow flies (Diptera: Calliphoridae) perform important yet often overlooked roles in ecosystems as decomposers, pollinators and vectors of disease. Central to these functions are their associations with microbial communities, which are maintained through close contact with diverse microbe‐rich substrates such as carrion, dung and flowers.
Paige Matheson, Amy Vaughan, Elahe Parvizi, Nathan J. Butterworth, Manpreet K. Dhami, Angela McGaughran   +5 more
wiley   +1 more source

Knowledge gaps in tubular gut tumours: a critical appraisal of the 6th edition of the World Health Organization classification of tumours

The Journal of Pathology, Volume 270, Issue 1, Page 4-22, September 2026.
Abstract Gastrointestinal cancer is a global health problem. In the new 6th edition of the World Health Organization Classification of Tumours (WCT) of the Digestive System, updated evidence and guidance is provided for the aetiology, pathogenesis, diagnosis, classification, grading, staging and prognosis of these tumours.
Iris D Nagtegaal, Elizabeth A Montgomery, Alexandros D Polydorides, Anthony J Gill, Motohiro Kojima, Mark J Arends   +5 more
wiley   +1 more source

Quaternary structures of Streptococcus pneumoniae nucleoside diphosphate kinase: From hexamers to supramolecular assemblies

Protein Science, Volume 35, Issue 9, September 2026.
Abstract The nucleoside diphosphate kinase (NDK) is a key enzyme that controls the balance of nucleotide pools in all living organisms. Beyond this fundamental role, NDKs exert pleiotropic effects in many cellular processes, including cell development, signal transduction, differentiation, tumor metastasis, and gene expression. The quaternary structure
Julie Kerboeuf, Paul Nouri, Frédéric Galisson, Laetitia Daury, Marie‐France Giraud, Olivier Lambert, Cédric Orelle, Lionel Ballut, Elise Kaplan, Jean‐Michel Jault, Cécile Gonzalez   +10 more
wiley   +1 more source

Comparative Safety Analysis of Targeted Synthetic and Biologic Disease‐Modifying Antirheumatic Drugs Among Patients With Rheumatoid Arthritis: A Nationwide Cohort Study in Japan

International Journal of Rheumatic Diseases, Volume 29, Issue 9, September 2026.
ABSTRACT Aim To compare risks of malignancy, opportunistic infections, and venous thromboembolism between the targeted synthetic disease‐modifying antirheumatic drugs (tsDMARDs) and biologic DMARDs (bDMARDs) at the 2nd and 3rd lines of therapy (LOT). Methods We conducted a cohort study using the National Database of Health Insurance Claims (2013–2021).
Shiori Nishimura, Toshitaka Hirano, Soko Setoguchi, Hiroki Matsui, Yoshinori Takeuchi, Yasushi Inoue, Yoshiya Tanaka, Kunihiro Yamaoka, Yoichi Ii, Shintaro Hiro, Masato Hoshi, Naonobu Sugiyama, Yutaka Matsuyama, Hiraku Kumamaru   +13 more
wiley   +1 more source

Imaging Characteristics of Pylorogastric, Duodenogastric, and True‐Gastrogastric Intussusception in 25 Dogs and One Cat

Veterinary Radiology &Ultrasound, Volume 67, Issue 5, September 2026.
ABSTRACT Gastric intussusception in dogs and cats is uncommon, and there are multiple variations described in the literature. The aim of this study was to describe the imaging characteristics of pylorogastric (PG), duodenogastric (DG), and true‐gastrogastric (true‐GG) intussusceptions.
Dylan Burton, Linda Dillenbeck, Megan Stadler, Wilfried Mai, Anthony Fischetti, Christine Gremillion, Pablo Espinosa‐Mur, Jaime Rechy, Alexandra Gibalski, Kelsey Cline   +9 more
wiley   +1 more source

Evaluation of Novel Isatin–Schiff Base Derivatives: Monoamine Oxidase Inhibition and Antimicrobial Assessment

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Five novel series of isatin–Schiff base derivatives are synthesized and evaluated for neuroprotective and anti‐infective potential. The compounds demonstrate exceptional, reversible, and competitive monoamine oxidase inhibition, with chloro‐substitutions dictating isoform selectivity.
Marthinus J. Jooste, Stephanus J. Cloete, Anél Petzer, Jacobus P. Petzer, Theunis T. Cloete   +4 more
wiley   +1 more source

NLRC5‐Deficient Macrophages Promote a Tumor‐Permissive Phenotype via AXL‐ and MERTK‐Mediated Efferocytosis

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
Defective NLRC5 signaling in macrophages drives TAM phenotype and anti‐inflammatory responses via STAT3/ERK, leading to tumor‐permissive conditions and gastric lymphoid neogenesis during Helicobacter infection. ABSTRACT The innate immune protein NLRC5 plays a key role in cancer immune surveillance.
Shambel Araya Haile, Alessandra Gatta, Nina Colon, Dana J. Philpott, Thomas A. Kufer, Le Ying, Dongmei Tong, Richard L. Ferrero   +7 more
wiley   +1 more source

Increased Risk of Environmental and Endemic Infectious Diseases in Sjögren's Disease: A Retrospective Analysis (2015–2023)

ACR Open Rheumatology, Volume 8, Issue 8, August 2026.
Objective Sjögren's disease (SjD) is a chronic autoimmune disease with a complex etiology, where pathogens may influence disease development or progression. Although SjD is not communicable, environmental and endemic pathogen exposures may influence its onset or progression.
Swetha K. Shankar, Taylor C. Boone, Eliza C. Diggins, Melodie L. Weller   +3 more
wiley   +1 more source

Xstainer: A Novel Virtual Staining Tool Powered by Advanced Deep Learning Techniques

Advanced Intelligent Systems, Volume 8, Issue 8, August 2026.
Xstainer is a deep learning–based virtual staining framework that converts hematoxylin and eosin‐stained whole slide images into multiple histochemical stains, including Masson's trichrome, Periodic acid‐Schiff, Jones methenamine silver, and Toluidine blue.
Fatma Nur Kinali, Derya Demir, Kutsev B. Ozyoruk, Yasin Almalioglu, Emre C. Kose, Drew F. K. Williamson, Gurdeniz Serin, G. Evren Keles, Banu S. Kumbaraci, Ceren Utku, Uguray P. Hacisalihoglu, Ilknur Turkmen, Figen Ozturk, Kayhan Basak, Yavuz Nuri Ertas, Mehmet Turan   +15 more
wiley   +1 more source