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Pathogenesis of Helicobacter pylori infection

Springer Seminars in Immunopathology, 2005
Helicobacter pylori induces chronic gastritis, the strongest known risk factor for peptic ulcer disease and distal gastric cancer, yet only a fraction of colonized individuals ever develop clinical disease. H. pylori isolates possess substantial genotypic diversity, which engenders differential host inflammatory responses that influence pathologic ...
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Immunobiology of Helicobacter pylori infection

Current Opinion in Immunology, 1997
Helicobacter pylori is a 'slow' bacterial pathogen. While infection is usually acquired early in life, only decades later does severe pathology appear. During this long period of incubation, the host mounts a vigorous immune response against H. pylori which fails to resolve the infection and may in fact contribute to the severity of the disease. In the
J L, Telford   +3 more
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The Epidemiology of Helicobacter pylori Infection

Epidemiologic Reviews, 1991
The evidence that H. pylori causes gastritis in humans comes from both primary and secondary observations. The most important primary observations are the human volunteer studies, the animal models, and the treatment studies with antimicrobial agents. Supporting information comes from studies showing the specific association of H. pylori infection with
D N, Taylor, M J, Blaser
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Treatment of Helicobacter Pylori Infection

American Journal of Therapeutics, 1998
Helicobacter pylori infection has been shown to be the principal cause of peptic ulcer disease and has been associated with MALT lymphoma and gastric cancer. Eradication of H. pylori has been shown to change the natural history of peptic ulcer disease by preventing relapse and to reduce health care expenditures when compared with traditional therapy ...
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DIAGNOSIS OF HELICOBACTER PYLORI INFECTION

Gastroenterology Clinics of North America, 1993
In conclusion, H. pylori infection can be detected by a variety of methods. The simplest, least expensive noninvasive method is serologic testing. Unfortunately, positive serology can only presume current infection. Urea breath testing is also noninvasive and is positive only in the setting of current infection; it is more expensive than serology and ...
K E, Brown, D A, Peura
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Clarithromycin for Helicobacter pylori infection

Expert Opinion on Pharmacotherapy, 2000
Helicobacter pylori, a Gram-negative organism that survives in the deep mucus layer and attaches to the gastric surface cells, is estimated to be present in up to one-half of the US population. Chronic H. pylori infection causes chronic gastritis, peptic ulcer diseases and even gastric cancer.
Graham, DY, Leung, WK
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Treatment of Helicobacter pylori infection

BMJ, 2008
#### Summary points Helicobacter pylori is one of the most common human infections, and about half of the world’s population carries this organism. Since its discovery in 1984, H pylori has been recognised as a major cause of several upper gastrointestinal diseases.1 2 As with other chronic infectious diseases, several antibiotics must be given ...
FUCCIO, LORENZO   +5 more
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Helicobacter pylori infection

Current Opinion in Infectious Diseases, 2012
This review is aimed at describing the main findings of 2011 on the aspects of Helicobacter pylori-related gastric disease linked to CagA and to T-regulatory cells (Treg), and on the attempts to improve the treatment efficacy.Recent findings presented in this review are as follows: CagA interferes with tumor suppression; tolerance protects from H ...
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Helicobacter pylori infection in children

Current Problems in Pediatrics, 2001
A number of scientific breakthroughs since H pylori first became recognized as a human pathogen have increased our understanding of the pathogenesis of gastroduodenal disease. In particular, advances in molecular bacteriology and the complete sequencing of the H pylori genome in 1999, and soon thereafter the human genome, provide tools allowing better ...
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Helicobacter pylori infection and diabetes.

Minerva medica, 2010
The bacterium Helicobacter pylori (H. pylori), prime causal agent of gastroduodenal diseases, has been involved in various aspects of several extragastric manifestations. Although currently available data do not provide proof of its role in most of them, a potential relationship cannot be ruled out. In the present review, the consistency of a role of H.
Ojetti, Veronica   +5 more
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