Results 31 to 40 of about 60,361 (264)

Effects of Cutter Geometrical Features on Machining Polyetheretherketones (PEEK) Engineering Plastic

Journal of Mechanical Engineering and Sciences, 2014
When polyetheretherketone is used in structural applications it generally undergoes additional machining operations in order to form components. Machining PEEK can be a challenging task for manufacturers, however, especially when using a conventional ...
R. Izamshah, N. Husna, M. Hadzley, M. Amran, M. Shahir, M. Amri   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

RESEARCH ON CUTTING FORCE MODELLING AND INFLUENCE FACTORS FOR END MILLS WITH VARIABLE-HELIX ANGLE

Jixie qiangdu, 2017
Variable helix cutter can reduce the location error of the finished surface,leading to a more accurate machining operation.Considering the geometries of variable pitch and helix angle,and the piecewise continuous regions of the cutting,an analytical ...
JIN Gang, LI Hua, HAN JianXin, LI Dong, QI HouJun   +4 more
doaj  

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Influence of Gear Helix Angle on Noise of Door Controlled Reducer

Jixie chuandong, 2022
Gear noise has become an important index to check the gear processing quality， and it is also a common problem in gear application. In order to effectively solve the noise problem of gears in use， a method which can appropriately increase the helix angle
Aiqun Xu, Sheng Rao
doaj  

Investigation of thermal analysis and pressure drop in non-continuous helical baffle with different helix angles and hybrid nano-particles

Case Studies in Thermal Engineering, 2022
In this study, shell and tube heat exchanger with non-continuous helical baffles (NCHB-STHX) is modeled numerically. This heat exchanger has varied applications in different fields of science and industry.
P. Jalili, K. Kazerani, B. Jalili, D.D. Ganji   +3 more
doaj   +1 more source

Milling dynamics of flexible part with helix angle

Procedia Engineering, 2011
AbstractThe present study has been undertaken in order to investigate the stability behavior of the flexible parts milling after considering an improved milling cutter helix angle model in which the total cutting force was obtained by integrating the differential cutting forces along the in-cut-portion of the flute.
Akhtar, Muhammad Masud, Huang, Xiang, Wenliang, Chen, Lin, Zixiong   +3 more
openaire   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source