Results 81 to 90 of about 60,573 (274)

Advancing pharmacometrics in Africa—Transition from capacity development toward job creation

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.
Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai, Samer Mouksassi, Innocent G. Asiimwe, Craig R. Rayner, Steven Kern, Phumla Sinxadi, Paolo Denti, Eric Decloedt, Catriona Waitt, Bernhards R. Ogutu, Rik de Greef   +10 more
wiley   +1 more source

Plasmodium and soil-transmitted helminth co-infection : epidemiological interaction and impact among children living in endemic areas of Bagamoya, coastal region of Tanzania [PDF]

, 2015
Background: Parasitic infectious agents rarely occur in isolation and multiparasitism is a norm among population living in poor resource settings of developing countries.
Masoud, Nahya Salim
core   +1 more source

Fertilizer Sustainability: A Conceptual Framework for Assessing Equitable and Sustainable Soil Inputs

Sustainable Development, EarlyView.
ABSTRACT Modern industrial agriculture is predicated largely on the production and utilization of chemical fertilizers. Although this approach has played an integral role in increasing food security in many parts of the world, the long‐term sustainability of this resource‐intensive approach is questionable.
Benjamin Wilde, Roman Hüppi, Gina Garland, Rafaela Feola Konz, Kenza Benabderrazik, William Thompson, Martin Hartmann, Bernard Vanlauwe, Kokou Kintche, Leonhard Späth, Matieyedou Konlambigue, Johanna Jacobi, Johan Six   +12 more
wiley   +1 more source

Mucosal immune responses following intestinal nematode infection. [PDF]

, 2014
In most natural environments, the large majority of mammals harbour parasitic helminths that often live as adults within the intestine for prolonged periods (1-2 years).
Harris, N. L., P. J. Cooper, Zaph, C, Cooper, P. J., C. Zaph, Cooper, PJ, Harris, NL, Zaph, C., Cooper, Philip, N. L. Harris, Cooper, Philip John   +10 more
core   +1 more source

Benzimidazole Anthelmintic Compounds Albendazole and Fenbendazole Show Distinct Toxicity on the Nitrogen Fixing Bacterium Mesorhizobium loti and Its Symbiosis With Lotus japonicus

Environmental Toxicology, EarlyView.
ABSTRACT Veterinary medicines, which reach the soil mostly through the application of contaminated manures, can affect beneficial soil microorganisms, such as nitrogen‐fixing rhizobia bacteria, which engage in important symbiotic associations with plants.
Polyxeni Gorgia, Stathis Lagos, Christina N. Nikolaou, Nikoleta Basdeki, Christos Papadopoulos, Dimitrios G. Karpouzas, Daniela Tsikou   +6 more
wiley   +1 more source

Soil-transmitted helminth reinfection after drug treatment : a systematic review and meta-analysis [PDF]

, 2012
BACKGROUND: Soil-transmitted helminth (STH) infections (i.e., Ascaris lumbricoides, hookworm, and Trichuris trichiura) affect more than a billion people. Preventive chemotherapy (i.e., repeated administration of anthelmintic drugs to at-risk populations),
Charles H. King (78462), Xiao-Nong Zhou (92570), King Charles H., Sara Melville (165920), King, C. H., Jia, T. W., Utzinger, J., Jürg Utzinger (39609), Zhou Xiao-Nong, Jia Tie-Wu, Sara Melville, Zhou, X. N., Charles H King, Utzinger Jürg, Tie-Wu Jia, Melville, S., Melville Sara, Xiao-Nong Zhou, Jürg Utzinger, Tie-Wu Jia (165917), Utzinger, Jürg, King, Charles H., Jia, Tie-Wu, Zhou, Xiao-Nong, Melville, Sara   +24 more
core   +1 more source

Biology, ecology, and conservation of the Italian hare Lepus corsicanus: a review

Wildlife Biology, EarlyView.
The Italian hare Lepus corsicanus, an endemic lagomorph of Italy, serves as a critical case study in evolutionary biology and conservation. Once taxonomically debated, modern genetic and morphological analyses confirm its status as a distinct Pleistocene lineage restricted to the central‐southern Italian Peninsula and Sicily.
Pierangelo Freschi, Valter Trocchi
wiley   +1 more source

CD4 T Cells in Mycobacterium tuberculosis and Schistosoma mansoni Co-infected Individuals Maintain Functional TH1 Responses

Frontiers in Immunology, 2020
Mycobacterium tuberculosis (Mtb) is a serious public health concern, infecting a quarter of the world and leading to 10 million cases of tuberculosis (TB) disease and 1. 5 million deaths annually.
Taryn A. McLaughlin, Jeremiah Khayumbi, Joshua Ongalo, Joan Tonui, Angela Campbell, Salim Allana, Samuel Gurrion Ouma, Felix Hayara Odhiambo, Neel R. Gandhi, Neel R. Gandhi, Cheryl L. Day, Cheryl L. Day   +11 more
doaj   +1 more source

The impact of helminths on the response to immunization and on the incidence of infection and disease in childhood in Uganda: design of a randomized, double-blind, placebo-controlled, factorial trial of deworming interventions delivered in pregnancy and early childhood [ISRCTN32849447]. [PDF]

, 2007
BACKGROUND: Helminths have profound effects on the immune response, allowing long-term survival of parasites with minimal damage to the host. Some of these effects "spill-over", altering responses to non-helminth antigens or allergens.
Quigley, Maria A, Morison, Linda, Namujju, Proscovia B, Kabatereine, N, Quigley, MA, Namujju, PB, Muhangi, L, Kizza, Moses, Muwanga, Moses, Kizza, M, Nampijja, M, Muwanga, M, Muhangi, Lawrence, Nampijja, Margaret, Whitworth, James AG, Ndibazza, J, Elliott, Alison M, Elliott, AM, Morison, L, Ndibazza, Juliet, Whitworth, JAG, Kabatereine, Narcis   +21 more
core   +1 more source

Host‐mediated filtering and interspecific associations structure strongyle parasite communities in Sable Island horses

Journal of Animal Ecology, EarlyView.
Using individual‐level nemabiome metabarcoding of 3147 samples from 916 horses on Sable Island over 10 years, we generate the largest dataset of its kind to date. This unprecedented scale enables a rare test of the processes structuring parasite communities in a natural system, revealing dominant host‐mediated filtering and predominantly positive ...
Sangwook Ahn, Philip D. McLoughlin, Jocelyn Poissant   +2 more
wiley   +1 more source