Results 71 to 80 of about 1,881,560 (314)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

The Relationship of Help-Seeking Inclinations to Traditional Predictors of Academic Success and First-Semester College GPA

open access: yesJournal of College Orientation, Transition, and Retention, 2013
Inclination to seek help was measured among a cohort of first-time, full-time freshman at a private university prior to the start of their first semester. The item involved a 10-point scale defined with contrasting terms at each end (i.e.
Michael J. Roszkowski
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Relationship education and counselling: recent research findings [PDF]

open access: yes, 2015
This paper reviews the research on relationship education and relationship counselling. The paper investigates the effectiveness of these strategies in working with couples who are at varying stages of their relationship - from highly satisfied at the ...
Cathryn Hunter, Joanne Commerford
core  

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Psychological help-seeking in the United Kingdom: a health-belief model approach

open access: yes, 2021
Much research exists pertaining to psychological help-seeking behaviors and intentions in the United States (U.S.; Levinson & Ifrah, 2010; Vogel & Wester, 2003; Wendt & Shafer, 2015; Ægisdóttir & Gerstein, 2009), yet little research considers ...
Stone, Rebecca M.
core  

Cultural differences in professional help seeking: A comparison of Japan and the U.S.

open access: yesFrontiers in Psychology, 2013
Previous research has found cultural differences in the frequency of support seeking. Asians and Asian Americans report seeking support from their close others to deal with their stress less often compared to European Americans. Similarly, other research
Taraneh eMojaverian   +2 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Attitudes toward help seeking

open access: yes, 2013
This study was designed to explore the relationship between attitudes toward help seeking, the ethnicity of the psychological help provider, and the level of cultural mistrust toward Jews. A sample of 102 Israeli Arab undergraduate students from Haifa,
Daoud, Jamalat
core  

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